Background

Dental implantology has evolved as an advantageous treatment method for dental rehabilitation and prosthetic restoration of partial or fully edentulous jaws [1, 2]. Sufficient amount and quality of bone remains a determining requirement for successful long-time implant survival and success and to prevent peri-implant disease [3,4,5]. Physiologic bone loss has been reported in various studies as a logical consequence after tooth extraction [6, 7]. In cases of severe bone loss—mostly due to long time interval since tooth removal, unfavorable load, infection, trauma, or other reasons—bone frequently needs to be augmented prior to or during implant placement [8, 9]. Different augmentation techniques have been developed depending on localization, extent, and configuration of the bone defect [10, 11].

If alveolar bone loss is limited, bone splitting and spreading are useful techniques for adaptation to the local conditions, although this may be difficult to apply in strong cortical bone such as the mandible [12]. Narrow diameter implants have also been proven to serve as possible solutions in horizontally compromised bone [13]. However, in cases of severe horizontal bone loss, horizontal augmentation of the mandibular alveolar ridge may be necessary and can be achieved by a variety of surgical approaches [9]. These procedures include insertion of bone grafts or stimulating bone formation in terms of guided bone regeneration [14,15,16,17]. Autologous bone is still regarded as gold standard given its biological properties [9, 18]. However, due to aspects like donor site morbidity, prolonged time of surgery and unpredictable resorption dynamics, a variety of allografts, xenografts and synthetic materials have been introduced into the market and numerous compositions are commercially available. Moreover, these grafts are commonly combined with autologous bone to improve compatibility and combine the advantages of these materials [19]. Additionally, this diversity is extended by different surgical techniques and protocols. Due to the enormous number of materials and techniques, a randomized controlled trial to evaluate and compare all the different approaches would be impossible to conduct. However, there exist scientific reports on the topic that can provide a considerable body of knowledge. For instance, Troeltzsch et al. provide a comprehensive analysis of the available literature for the augmentation of the alveolar ridge [20]. Bone formation in the augmented areas varied from 33.2 ± 14.9% for allogeneic grafts to 56.0 ± 25.6% for mixtures of autogenous and other grafting materials. The authors derive a horizontal gain of 3.7 mm for particulate, compared to 4.5 mm for block grafts. Despite a detailed evaluation of horizontal and vertical dimension, analysis of the donor site (autogenous iliac crest, calvarium, mandible, allogeneic) or the subclassification of the results with regard to the use of membranes and meshes, distinct results for the horizontally compromised lower jaw as recipient site remain elusive.

Furthermore, implant survival and success in concomitantly vs. subsequently placed dental implants are not reported uniformly, so that this aspect remains unclear to date. Thus, the aim of this report was to systematically review the available data and potentially draw conclusions about the efficacy in gaining bone width, implant survival and success rates after or accompanying horizontal ridge augmentation procedures using autologous, xenogeneic, synthetic, or allogeneic materials or combinations of these in cases of bone loss in the lower jaw, which require lateral augmentation. The idea was to systematize approaches and give recommendations on this complex and relevant subject by assessing the efficacy of grafting materials with respect to clinically relevant parameters.

Results

Study characteristics

The initial electronic search identified a total of 15,643 titles (Fig. 1). 890 studies were selected for further assessment of the abstract after screening of the titles. 64 articles were added by manual search. Out of these, a total of 866 were excluded. Subsequently, 88 full-text articles were obtained, and “Materials and methods” and “Results” sections were investigated. Only eight studies ultimately met the inclusion criteria (Fig. 1). The reasons for exclusion are depicted in Table 1.

Fig. 1
figure 1

Tree diagram of exclusion/inclusion of studies for this systematic review

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Table 1 Specification of excluded studies after full-text analysis
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Data synthesis and/or meta-analysis were not performed due to the heterogeneity of the study designs and parameters. Risk of bias of each study is given in Table 2. Information on additional risk of bias across studies is elaborated in “Discussion” section.

Table 2 Assessment of risk of bias according to The Cochrane Collaboration’s tool for RCTs, the ROBINS-I tool was applied for prospective cohorts, and the Checklist for Case Series from the Joanna Briggs Institute
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Efficacy of augmentation procedures in horizontally resorbed ridges

Eight studies met the inclusion criteria containing a total of 276 procedures of xenogeneic, allogeneic, or autogenous bone graft applications in horizontal ridge defects. Outcome measures, approaches and materials varied from study to study. The mean follow-up was 26.0 months across all included studies, with a maximum mean observation period of 40.5 months, and minimum mean observation period of 6 months. Particulate material as well as bone blocks were used as grafts in the studies (see Figs. 2 and 3).

Fig. 2
figure 2

Schematic of horizontal bone loss in the lower jaw after crestal gingival exposure (A). Principle of bone-block grafting and fixation with screws (B). Depiction of lateral augmentation using particulate bone and membrane placement for coverage (C). Gaining of horizontal bone width by surgical splitting of the alveolar ridge (D)

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Fig. 3
figure 3

Clinical example of a 41-year-old female patient presenting with missing tooth 31 and consecutive horizontal bone loss (A). For dental, functional and esthetic rehabilitation, simultaneous implant placement and lateral augmentation was performed. Implantation of Conelog Progressive Line, harvesting of a retromolar bone block from the mandibular angle with a trephine drill, augmentation and microscrew fixation (1.0-mm steel screws) after rounding of the edges with a burr (B). Relining and fitting with particulate bone placement (C). After 5 months of healing time, implant exposure and fixation screw removal, sequential abutment fitting and placement of dental crown were performed (D)

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The autologous block grafts used in the included studies were taken from the mandibular ramus [99, 100] or as bone chips from the posterior mandible/retromolar region [100,101,102]. A combination of autografts with xenografts or allografts was used in four studies. All augmentation sites were covered, either by membranes or platelet-poor plasma. Table 3 shows the variety of outcome measures used in the included studies.

Table 3 Methodological characteristics of the selected studies, the regenerative objective (simultaneous or staged), the types of interventions and measured outcomes
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Even though this review aims to report the results in a standardized way, the wide range of different settings, study protocols and outcome parameters limit conclusions in an evidence-based manner. Hence, only circumscribed quantitative data could be analyzed and this review should be perceived with a narrative approach. The study design ranged from (randomized) controlled clinical trials to pro- and retrospective studies. Particularly, the outcome measures varied extensively in the presented reports. All studies referred to clinical assessment and radiographic imaging when reporting outcome parameters (Table 4).

Table 4 Assessment parameters and study results
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The majority of the included patients were female. Where specified, individuals were 70 women (72.2%) compared to 27 men (27.8%). The inclusion criteria for augmentation procedures and subsequent implant therapy did also vary, as for instance in some studies smokers were explicitly excluded from the study and in other studies smoking status of the patients was only recorded (Table 5). In all studies, the systemic health status was addressed in the inclusion criteria. However, the parameters ranged from patients being “in good health” to listing of specific systemic medical conditions such as “connective tissue diseases” and “immunodeficiencies”.

Table 5 Patient characteristics and implant specification
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The horizontal mandibular bone serving as indication for augmentation procedures in the studies was also reported in various ways. The reported projected bone increase needed for implant placement was 3 mm of bone width [103]. Other groups performed lateral augmentation in case of residual width from < 4 mm [102, 104] to < 6 mm [105]. The article of Schwarz-Arad et al. proposed a need for augmentation if an implant of 6 mm in height could not be placed without the risk of damaging anatomical structures. The horizontal gain of bone width after the healing process was evaluated radiographically in seven studies. A gain of horizontal bone width was reported in seven of eight studies, with a mean of 4.8 mm, ranging from 3.2 to 5.7 mm (Table 4).

No significant difference was found regarding the outcome variables due to the heterogeneity of reporting the data. The use of rhPDGF-BB in one study significantly limited the resorption of augmented bone [101]. This observation was true for both the group having been augmented with corticocancellous allograft of the iliac bone and the control group of bone chips from the retromolar region. Marginal bone loss during the healing period was evaluated in four studies, with a mean of 0.5 mm, and values between 0.2 and 1.1 mm. Histologic findings were reported in three studies [102, 104, 105]. In the study conducted by Urban et al., a xenograft was combined with autologous bone and the mandible was augmented using particulated material. Histological results showed autologous bone in 31.0%, ABBM, remaining xenograft in 25.8% and marrow space in 43.2% of the derived samples. Di Stefano et al. and Silva et al. quantified newly formed bone at 35.0% and 31.8%, respectively. None of the studies reported on implant success rates. Implant survival rates were shown to be above 92.5% in the included studies at 36 months of last follow-up (Table 4). Four studies reported on crestal incision techniques with an implant survival rate ranging from 92.5 to 100.0% at 18.9 to 37 months of follow-up. One study group used a lateral incision for the augmentation and the surgical approach was not specified in the remainder of the reports. The declared implant survival rate was 96% to 100% with a mean follow-up of 10 to 40.5 months.

One study reported up to 3.6% complications concerning the grafted site at the follow-up [101]. Although data of horizontal and combined horizontal–vertical expansion of the atrophic mandible have not been reported separately in the investigated work by Schwartz-Arad et al., the total complication rate of mandibular augmentation was found to be 6.1%. However, only two of the seven complications occurred in solely horizontal augmented sites. Failure of one graft [6.3%] was reported in the study by Urban et al., when looking at the data of mandibular augmented sites. A comparatively high failure rate of six bone grafts was observed in the study by Nissan et al. [20.7%]. Although distinct failure rates in the horizontally augmented mandible are missing, most of the allograft failures [71.0%] in this study occurred in the posterior mandible. Barbu and colleagues reported graft exposure 2 weeks after the augmentation in one patient. Another week later clinical signs of necrosis led to removal of the graft resulting in a failure rate of 4.2% [100]. In conjunction with bone graft failure rates of 0.0% in four reports, the overall average amounts to 4.4% across all studies.

Discussion

Successful long-time survival and success of dental implants depend on sufficient amount and quality of bone. In case of severe horizontal bone loss, horizontal ridge augmentation of the mandibular ridge can provide optimum conditions for successful implant placement. However, the jaw recipient site (maxilla or mandible) has been shown to influence graft resorption [106]. Therefore, the aim of the present review was to systematically examine the clinical efficacy of augmentation procedures in horizontally resorbed mandibular ridges in terms of horizontal bone gain, implant success and survival after a follow-up period of at least 6 months. The results of this systematic review indicate a high variability in types of interventions to gain horizontal bone width. However, all techniques were able to create a sufficient horizontal bone gain. Implant survival was very good with results exceeding 92.5% between 12 and 36 months of follow-up.

Even though the present review aims to report the results in a standardized way, the wide range of different settings, study protocols and outcome parameters prevent drawing conclusions in an evidence-based manner. Only eight studies met the inclusion criteria and could be considered for this review, which is one of the main limitations of this study. However, the authors chose not to further modify the inclusion criteria to provide sufficient evidence. Additional inherent limitations are different study designs, different materials used, different assessment methods and prominently different outcome measures throughout. Therefore, comparisons from study to study are limited and comprehensive statistical analysis was not feasible. Augmentation procedures always included the use of membranes. In all studies, combinations of materials (autologous bone combined with xenografts or allografts) were used. The minimum bone width to include patients was either not specified or differed from study to study. Only three of the evaluated studies were randomized [100, 101, 103]. None of the studies reported on implant success rates. This results in the demand of further studies particularly focusing on how implants survive. This also includes the claim on reporting prosthetic data that were proposed at the 4th EAO Consensus Conference [107].

As case reports or case series with less than five patients did not meet the criteria for inclusion in this review, a considerable part of the pre-selected publications (19 in total) had to be dismissed in the process of data extraction. An observation period falling below 6 months after augmentation was reported in eight studies and considered too short to evaluate augmentation procedure and implant success. A major shortcoming during thorough data extraction was whether the horizontal ridge augmentation took place in the upper or lower jaw. As it has been reported that the augmentation procedure in the mandible may be correlated with higher complication rates and thus might be less predictable, the need for reporting the data in this distinctive way remains high [108].

Overall results show that all bone grafts that were used in the included studies have the potential to increase horizontal bone width. Even though no analysis could be carried out due to the lack of homogeneous data and outcome results, the descriptive data suggest a slightly better performance of bone blocks for horizontal augmentation of the lower alveolar ridge than for particulate material. In contrast, Urban and colleagues found comparable results on bone block augmentations using particulate autologous bone grafts in combination with allogeneic material (horizontal bone gain of 5.3 mm in mean).

Troeltzsch et al. conducted a comprehensive pooled analysis with regard to clinical efficacy of grafting materials in alveolar ridge augmentation over a weighted mean follow-up of 27.4 months (range 3–168 months) [20]. In this review, the mean follow-up was 26.0 months across all included studies, with a maximum mean observation period of 40.5 months, and minimum mean observation period of 6 months. After augmentation, the weighted mean horizontal gain for all particulate grafting materials was 3.7 ± 1.2 mm, with variation between 2.2 ± 1.2 mm (synthetic) and 4.5 ± 1.0 mm (mixtures of autogenous bone with allogeneic/xenogeneic grafting material) without statistical significance in the work of Troeltzsch et al. The authors derive a horizontal gain of 4.5 ± 1.2 mm for block grafts. Limited to the inclusion criteria of our review, a gain of horizontal bone width of the mandible in seven of eight studies, with a mean of 4.8 mm, ranging from 3.2 to 5.7 mm was observed. All but one study, reported low bone graft failure rates of 4.4% in average. One group of authors, that used bone-block allografts combined with particulate mineralized freeze-dried bone allograft or particulate bovine bone xenografts, reported a failure rate of 20.7% [103]. The reasons were only discussed marginally, and the authors suggested a relation to the localization of the augmentation as all failures had occurred in the posterior mandible. However, a successful use of allografts was stated in further studies that did not meet the inclusion criteria of this review. This suggests that other reasons than the use of allografts might be responsible for the high failure rate in the above-mentioned study [105, 109].

The augmentation procedure and subsequent complication rates may also be associated with the surgical approach. Horizontal ridge augmentation techniques in the mandible have been shown to be very efficient and safe. However, the method of placing narrow-diameter implants in horizontally resorbed alveolar ridges provides an alternative approach when bone loss is limited. Studies showed that results of narrow-diameter implants placed to support single crowns in the posterior region of the jaw did not differ from results of regular implants regarding the outcome parameters of marginal bone level, implant survival and success rates [110]. Moreover, recent studies suggest that narrow-diameter implants (2.75 to 3.25 mm) can successfully be used as minimally invasive alternative to horizontal bone augmentation in the posterior mandible with implant survival rates exceeding 97% [111]. A recent clinical trial over 2 years showed that patients receiving mini implants with shorter diameters of 1.8–2.4 mm had clinical outcomes similar to those of patients receiving conventional dental implants to support overdenture prostheses [112]. These results must be taken into account when considering horizontal ridge augmentation procedures in the mandible. To appropriately evaluate lateral augmentation techniques in the mandible, other approaches like the split bone block technique had to be excluded in the present review. Given the lack of information provided in the studies, no recommendation can be given concerning the surgical approach.

All studies included the use of a barrier membrane. Due to missing control groups without membranes, a beneficial effect of this procedure on horizontal ridge preservation techniques accompanying augmentation is conceivable but cannot be evaluated. However, literature regarding the reconstruction of peri-implant dehiscence defects suggests a beneficial effect of barrier membranes on the degree of defect filling [20]. Long-term follow-up data based on imaging results are not consistently provided. According to the guidelines of Albrektsson et al., the majority of crestal bone remodeling occurs during the first 2 years following implant-loading, therefore long-term (at least 2 years) follow-up of implants inserted in the augmented sites would be advisable [3]. Furthermore, bleeding and deep peri-implant pockets with crestal bone loss are closely related to the faith of newly formed hard tissues, which are reconstructed via GBR. Thus, implant success rate, which depends on change of crestal bone level and the lack of inflammatory signs, may represent a more relevant evaluation method of GBR efficacy than implant survival rate during long-term follow-ups.

Considering the limited number of included studies and the various approaches that were used, it is not possible to give concise recommendations for horizontal ridge augmentation procedures. Data of prospective randomized and controlled clinical trials regarding different horizontal ridge augmentation techniques including longer follow-up intervals, standardized outcome measures and distinguished results for the upper and lower jaw are missing. As implant success was not evaluated in any of the present studies, further investigations must be conducted including data on how implants and prosthetic reconstructions survive over time.

The role of growth factors in horizontal ridge augmentation must be outlined in a more specific manner. Two of the included studies did in fact work with growth factors—rhPDGF and PRP/PPP, respectively. As the present review is not designed to outline the role of growth factors, no evidence-based conclusion can be drawn from the present data. However, it must be kept in mind that these growth factors present a bias in the present study, which must be considered when interpreting the results.

It is obvious that different surgeons prefer different surgical techniques according to their individual expertise. Therefore, a comparison of distinct GBR procedures in studies with a single surgeon in a split-mouth design hardly represents comparable data. Thus, randomized controlled trials might represent an objective approach with clinically relevant results if the procedures are performed by two different surgeons practicing their favorable techniques after randomization. This would filter the advantages against the individual skillset of the surgeon.

The primary objective can be concluded based on quantitative data, but from the secondary objectives only implant survival rate can be answered. It is of high interest whether the biological behavior of augmented sites is similar to pristine bone or not. Furthermore, bone block alone or bone block supported GBR techniques are compared with GBR techniques based on particulate bone and xenograft (composite graft). Due to the difficulties of these procedures, but also due to different extent and morphology of bone defects, it is very likely that the superiority of one therapy cannot be easily concluded. However, a standardized follow-up protocol with particular timing and assessment methods is needed for getting clear results regarding techniques and long-term implant success.

Data extraction and assessment were performed by two authors to reduce reviewer bias. However, this kind of bias cannot be ruled out completely. As there is a possibility that only studies were published with favorable outcomes or significant findings, a publication bias might exist. Accordingly, studies with a follow-up of less than 6 months could have been so-called “cancelled studies” due to a poor outcome and therefore are not recorded by the mentioned search strategy [80, 81]. As the data extraction is based solely on reported outcomes in the present studies, a reporting bias and incomplete outcome data might have been influenced the data assessment. Predominantly, in five of eight studies multiple biases exist regarding randomization and blinding within each study. Only one study by Amorfini et al. is reported to be a randomized clinical trial on the research topic, whereas the study by Nissan et al. uses randomization only for parameters like deficiency filling and the use of membranes [101, 103]. Barbu and colleagues divided patients between the use of particulate graft composition and membrane and the data were de-identified before research analysis [100]. No further specifics on blinding and randomization can be found. Possible risks of bias according to the Cochrane Collaboration’s tool for randomized controlled trials, as well as the ROBINS-I tool for prospective cohorts, and the Checklist for Case Series from the Joanna Briggs Institute are given in Table 2.

Materials and methods

Focused question and PICO

Does the outcome of horizontal mandibular augmentation using xenogeneic, synthetic, or allogeneic material differ from the outcome of autologous bone grafts with regard to gained quantity of bone width, implant survival, success and complication rate in patients that underwent resorption of the horizontal alveolar ridge? The PICO Question is depicted in Table 6.

Table 6 PICO Question
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Search strategy

A computerized literature search (Medline/PubMed and Cochrane Central Register of Controlled Trials (CENTRAL)) was performed for clinical studies, including articles published from January 1st, 1995, up to March 31st, 2021. Additionally, manual search was carried out in: International Journal of Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, Journal of Craniomaxillofacial Surgery, Journal of Clinical Periodontology, Journal of Periodontology, Clinical Oral Implants Research, International Journal of Oral Maxillofacial Implants, Clinical Implant Dentistry and Related Research, Journal of Implantology, Journal of Biomedical Materials Research. Furthermore, full-text articles of reviews published between January 2012 and March 2021 were obtained. An additional manual search was performed on these reviews to identify relevant studies. The language was limited to English. Risk of bias for RCTs was assessed in agreement with the Cochrane Collaboration’s tool [113, 114]. For non-randomized studies, the ROBINS-I tool was applied, and the Checklist for Case Series from the Joanna Briggs Institute [115]. The study followed the PRISMA guidelines (see Additional file 1: Table S1) [116] and was prospectively registered in the international prospective register of systematic reviews (PROSPERO) under registration number CRD42018082149 (www.crd.york.ac.uk/PROSPERO/). No contact was made to acquire additional data from the authors of the study. Any data report and subsequent conclusions are made based solely on published reports.

Search terms

The following search terms were applied: (“xenogeneic bone substitute” OR “synthetic bone substitute” OR “allogeneic bone graft” OR “xenograft” OR “allograft” OR “synthetic material” OR “lateral space” OR “bone graft” OR “guided bone regeneration” OR “alveolar ridge augmentation” OR “dental augmentation” OR “ridge atrophy” OR “GBR” OR “horizontal augmentation success” OR “horizontal ridge augmentation” OR “bone substitute” OR “alveolar bone graft” OR “alveolar bone loss” OR “alveolar resorption”). The search was limited to “human trial”. Accordingly, the MESH Terms “clinical study”, “clinical trial”, “controlled clinical trial”, “randomized controlled trial” were used.


AND

(“dental implants” OR “lower jaw” OR “alveolar ridge” OR “implant site” OR “mandible”). The search was limited to the MESH Terms “Humans” and “Clinical Trial”.

Inclusion criteria

Publications were considered when all of the following criteria were applicable:

  1. 1.

    Human, clinical trials with a minimum of five patients reported upon.

  2. 2.

    Horizontal augmentation with bone grafts or substitute materials prior to or accompanying implant placement.

  3. 3.

    Follow-up of at least 6 months in mean.

  4. 4.

    Metric outcome measures following surgical intervention.

Exclusion criteria

Publications limited to (1–4) or containing (5–13) the following were excluded:

  1. 1.

    In vitro studies

  2. 2.

    Animal (preclinical) studies

  3. 3.

    Cadaver studies

  4. 4.

    Case reports and reports based on interviews and charts

  5. 5.

    Vascularized free bone grafts

  6. 6.

    Only soft tissue augmentation

  7. 7.

    Distraction osteogenesis

  8. 8.

    Socket preservation techniques

  9. 9.

    Augmentation procedures after removal of malignant or benign tumors

  10. 10.

    Patients receiving radio- or chemotherapy

  11. 11.

    Results of patients that had been presented in prior studies of the authors

  12. 12.

    Only vertical augmentation procedures

  13. 13.

    Other bone preservation procedures, e.g., splitting or spreading.

Selection of studies

Two researchers (CK and LM) independently screened the publications derived from the online search based on the inclusion criteria. Subsequently, the abstracts of the selected titles were obtained and screened for meeting the inclusion criteria. If an abstract was not available in the database, the abstract of the printed article was used. Full-text articles of the selected abstracts were obtained. Again, a selection was made based on the inclusion criteria for the full-text articles. For this purpose, “Materials and methods” and “Results” sections of these studies were investigated. No additional data were obtained other than data included in the articles.

Data extraction and method of analysis

Two researchers independently analyzed all data using data extraction tables (CK and LM). Information on the following parameters was extracted: author(s), year of publication, study setting and study design, patient cohort (age range, mean age, gender, drop outs), follow-up (mean time and range), type of grafting material (autologous, allogeneic, xenogeneic, synthetic), type of fixation, type of graft preparation (particulate vs. block graft), type of barrier material used (collagen based, PTFE, polymer, titanium, none), the regenerative objective (two-staged vs. simultaneous), test/control groups, information on smoking or systemic conditions of the patients as well as the timing of implant placement, the assessment method and complications during or after surgery.

Outcome parameters

Metric data and clinical outcome on the following parameters were extracted, as indicated:

  • horizontal width (mm)

  • horizontal gain (mm)

  • loss of augmented bone width (%)

  • complication rate of surgical and post-surgical complications (%)

  • bone formation (%)

  • implant survival rate (%).

The data extraction was defined as follows:

  • Complications (%): complication rate in the augmented sites occurring during the observation period in percent.

  • Implant survival (%): survival rate of implants in the augmented area in percent.

  • Horizontal width I (mm): horizontal bone width before augmentation in mm.

  • Horizontal width II (mm): entire horizontal bone width at the end of the observation period in mm.

  • Horizontal gain (mm): horizontal result of gained bone in mm at the end of the observation period.

  • Loss (mm)/(%): difference between the initially augmented bone width and the entire horizontal bone width in millimeters/percent.

  • Bone formation (%): the bone formation rate is the mineral apposition rate multiplied with the surface area undergoing bone formation. Amount of newly formed bone in the defect area was calculated in percent.

Conclusions

A variety of approaches and materials exist for the reconstruction of bone width of the mandible. Only limited evidence with risk of bias is available on the impact of using particular grafts or bone blocks for horizontal augmentation in the lower jaw. The results of this review show outcomes for xenogeneic as well as autologous bone materials for horizontal ridge augmentation of the lower jaw. The use of allogeneic bone-block grafts in combination with resorbable barrier membranes must be re-evaluated. Data of randomized controlled clinical trials indicating superiority of specific horizontal ridge augmentation procedures in the lower jaw are still missing and worthwhile being investigated.