Objective

Thalassemia is a set of genetic disorders characterized by decreased or absent hemoglobin synthesis. Blood transfusion is required to control a severe form of thalassemia [1]. Blood transfusion and iron bromide absorption in the gastrointestinal tract, in either, are many times higher than normal, leading to iron overload. In patients with major thalassemia who have received blood transfusions, cardiac failure due to myocardial iron overload is the primary cause of death [2,3,4]. MRI uses as an appropriate modality for measuring liver and myocardial iron overload [5]. Because GRE sequences (T2* weighted) are more sensitive to tissue with iron, they are theoretically superior to spin-echo sequences for assessing myocardial iron concentration.

Because of the short imaging periods in this sequence, cardiac gated imaging with breath-holding can be used to reduce movement artifacts from heart muscle movement, blood flow, and respiratory movements [5]. Even though CMR T2* is the gold standard for detecting iron overload in myocardial muscle, diastolic cardiac dysfunction may be present even if T2* levels are normal [6]. It is crucial to assess the size and function of the ventricle in order to treat a variety of congenital and acquired cardiac diseases, including diastolic abnormalities [7]. This dataset contains CMR images and supplementary clinical data that researchers can utilize to evaluate heart function, particularly in TM patients with myocardial iron overload. They can also be used for image analysis and processing.

Data description

This dataset consists of unenhanced Cardiac MR Images from 50 subjects, including 37 confirmed TM patients and 13 healthy subjects. Images were obtained at the point of care in an inpatient setting with echocardiographic data for heart dysfunction in TM patients and supporting clinical symptoms from February 2016 to January 2019. Subjects in this study were over the age of 18 and who showed clinical signs of heart failure (shortness of breath, decreased activity, hand, and foot swelling, round the eye and chest pain, arrhythmia), LVEF < 50%, high mean arterial pressure, renal failure, diabetes mellitus, pulmonary hypertension, addiction, cardiovascular disease and infectious diseases during the study were excluded. All CMR tests were completed a week after the last blood transfusion. All participants gave their informed consent in writing and orally.

MRI exams were performed with the Siemens Avanto B17 (1.5 Tesla) machine (Siemens Medical Solutions USA, Inc.). All images are in DICOM format and are 16-bit gray-scale images with a resolution of 192 × 256 pixels. All patient-specific information is removed from image headers to protect patient privacy. Following that, all images associated with each patient are compressed and saved in RAR format. Table 1 shows a summary of the dataset. Breath-hold and retrospective gating were applied with True FISP sequences in the short axis. A Gradient multi-echo Dark Blood sequence was used in breath-hold and retrospective gating in 3 slices in the short axis plane and 8 echo times to assess myocardial iron overload. Technically, assessment of myocardial iron overload is in the papillary muscles, the ventricular wall, and the septum. An initial slice was selected from the papillary muscles, and the other two slices were placed at the same intervals at the top and bottom of the first cut. Additional data (such as age range, sex, BSA, LAEDV index, LAESV index, LASV index, and T2*), echocardiographic data (such as LAEDV index, LAESV index, LASV index, and LAEF), and some detailed clinical data (Serum ferritin level, transfusion starting age, chelation starting age, and T2* (ms) liver iron quantification) are given as “Data file 1” in Table 1. Table 1 lists the imaging parameters for these sequences as “Data file 2.” All images were evaluated visually by two board-certified radiologists and cardiologists. Table 1, “Data file 3”, contains a complete description of the methodology.

Table 1 Overview of dataset
Full size table

Limitations

  • A large number of images contain some form of motion artifacts.

  • Images were taken at a single general hospital in Mashhad, Iran, representing a predominantly Iranian population.