Introduction

Newly-marketed point-of-care ultrasound (POCUS) devices like the Butterfly iQ (iQ, Butterfly Network, Inc, Guilford, CT, USA) have generated significant excitement over their potential in emergency departments (EDs), critical care units, and resource-limited settings (RLS). Potential benefits of the iQ include small size, lower cost, integration with the user’s mobile phone or tablet, and use of silicon-chip based technology obviating the need for multiple transducers. There has been little critical evaluation of the device itself, particularly in RLS. We describe our use of the Butterfly iQ in routine clinical operations in a busy, high-acuity African ED and review its performance and applicability to RLS.

Personnel and setting

Five emergency physicians from the United States worked alongside the ED staff of a busy referral hospital in rural east Africa treating medical and surgical patients of all ages over a period of 10 consecutive weeks in the fall of 2019. All physicians have surpassed accepted POCUS training guidelines [1]. Two (SLB and JFS) have completed or are enrolled in a Point-of-care Ultrasound in Resource Limited Settings fellowship [2]. Advanced imaging is available, but access is limited by the need for payment prior to testing; in practice, patients often wait hours or days prior to imaging. Patients were selected by clinicians at the bedside if POCUS was indicated as a part of routine clinical care; therefore, informed consent was not required. Patients were scanned with the Butterfly iQ connected to an Apple iPad (iPad 5th Generation, Apple, Cupertino, CA, USA). Images were later reviewed for quality assurance by ultrasound fellowship-trained faculty. Final diagnoses were determined from a combination of the medical record, discussions with inpatient teams, and expert image review.

Results and discussion

The Butterfly iQ performed well and met clinician needs for a POCUS machine in this single RLS. Its advantages over cart-based machines are magnified, where financial resources, floor space, and reliable power may be scarce. Advantages and disadvantages of the Butterfly iQ are summarized in Table 1.

Table 1 Advantages and disadvantages of the butterfly iQ
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Advantages

The combination of flexibility and mobility of a single probe with preset modes replacing multiple transducers is the paramount benefit of the device. We successfully employed the iQ in a wide variety of scans and patient presentations (see Table 2, Figs. 1, 2, 3) and procedural guidance (see Table 3).

Table 2 Point-of-care ultrasound findings using Butterfly iQ in African Emergency Department
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Fig. 1.
figure 1

3-month-old male presenting with acute respiratory distress. POCUS revealed a dilated right atrium and ventricle with a prominent atrial septal defect, seen in parasternal long view (left) and a slightly modified apical four chamber view (right). LA, Left Atrium, LV, Left Ventricle, RA, Right Atrium, RV, Right Ventricle, *, Atrial Septal Defect

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Fig. 2
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Abdominal point-of-care ultrasound of a previously healthy 3-year-old male with abdominal pain, nausea, and vomiting diagnosed with intussusception, confirmed and treated by air contrast enema. a reveals a stereotypical “target sign”, hyperechoic compressed inner loop of bowel (*) telescoping within a hypoechoic, edematous outer loop (arrow). b reveals the target sign in another cross sectional plane, with multiple layers of telescoping bowel

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Fig. 3
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Musculoskeletal ultrasound of a young male patient with blunt trauma demonstrating two separate sections of tibial cortex (t), with displacement (arrows). Note the associated fracture hematoma visualized (*)

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Table 3 Procedures guided by Butterfly iQ in an African Emergency Department
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Image quality, particularly in the abdominal and musculoskeletal modalities, was excellent, though not generally up to the standards of a cart-based system. With few exceptions (see below), image quality in all modalities was adequate to answer the clinical question.

The software application is user-friendly, allowing rapid alternation between preset scanning modes, enabling multiple protocols on the same patient with only a few gestures. Some routine calculation functions (such as gestational age) were not available during our experience with the device. We found the increased screen size of an iPad compared to a mobile phone beneficial for most uses.

The cost of the device (approximately US$2000), plus a required $420 annual subscription fee to the cloud-based image storage) places it within reach of some individual clinicians, and many healthcare institutions, even in RLS. Battery life was adequate, usually enough to last an entire 12-h shift on a full charge, though we did not specifically measure continuous scanning time. When necessary, we were able to charge the device from main power on shift. Small, relatively inexpensive, third party solar-powered chargers could also provide additional charging.

Disadvantages

Echocardiography habitually seemed lower quality than other modes. There was an apparent drop in resolution and frame rate, most noticeably associated with the use of color Doppler. Like other pocket-sized devices, the iQ also lacks spectral Doppler. Despite these limitations, we were able to detect significant cardiovascular pathology. All views were generally obtainable, adequate to guide resuscitation, and answer basic clinical questions pertinent to the RLS [3].

Images are stored on a cloud-based server requiring internet access to upload. Until they are uploaded, the images remain in an "outbox", where they can easily be deleted. Without reliable internet access, many images remained in this "outbox” for the duration of our field work, inhibiting our ability to share or review images.

We encountered several challenges related to the device’s hardware. The first was periodic overheating, rendering further scanning impossible until the device cooled. Overheating was not appreciably tied to any specific scanning mode or function. We mitigated this by briefly running water over the waterproof end of the device until cooled. We noticed a small rubber seal loosening near the end of the transducer by the closing of our field experience, without any discernible change in function. We found the cord length (125 cm) slightly short, especially when performing POCUS-guided procedures. The probe itself weighs 0.7 lb (0.3 kg), more than twice most other transducers, and its footprint is larger than a phased array probe, which was occasionally problematic when placing ultrasound-guided peripheral IVs and scanning between ribs, respectively. This may have contributed to the decreased quality of some echocardiographic images.

Limitations

These findings represent a retrospective review of the authors’ personal experiences with the Butterfly iQ device during routine clinical work in an African ED in an attempt to evaluate its performance in RLS. Patients were scanned at the discretion of the clinician at the bedside or because of restricted access to other diagnostics, introducing the possibility of selection bias. No patient-oriented outcomes were assessed and no comparisons between devices were available.

Conclusion

The Butterfly iQ was employed in a wide variety of patient presentations, scanning indications, and procedural guidance in a busy, high acuity RLS ED. Advantages include its use of a single probe for multiple functions, small size, relatively low cost, and good image quality in most functions. Disadvantages include large probe footprint, lower, though adequate, cardiac imaging quality, frequent overheating, and reliance on internet-based cloud storage, but these were surmountable. We believe the iQ is an effective POCUS device for emergency care in the RLS and we will continue to employ it for patient care and clinical teaching.