Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a disease that primarily occurs in elderly individuals. However, it is difficult to diagnose and has a complex disease course. High-resolution computed tomography (HRCT) and lung function testing are crucial for its diagnosis and follow-up. However, the correlation of HRCT findings with lung function test results has not been extensively investigated.
Methods
This study retrospectively analysed the medical records and images of patients with IPF. Patients with evident emphysema and lung cancer were excluded. The diagnosis of all the included cases was confirmed following a discussion among specialists from multiple disciplines. The correlation of HRCT findings, including fibrotic score, HRCT lung volume, pulmonary artery trunk (PA) diameter and pulmonary vascular volume (PVV), with lung function test parameters, such as forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO), was analysed.
Results
A total of 32 patients were included. Higher fibrotic and PVV scores were significantly correlated with lower DLCO (r = − 0.59, p = 0.01; r = − 0.43, p = 0.03, respectively) but not with FVC. Higher PVV score significantly correlated with higher fibrotic score (r = 0.59, p < 0.01) and PA diameter (r = 0.47, p = 0.006).
Conclusion
Our study demonstrated the structural and functional correlation of IPF. The extent of lung fibrosis (fibrotic score) and PVV score were associated with DLCO but not with FVC. The PA diameter, which reflects the pulmonary artery pressure, was found to be associated with the PVV score.
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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown cause that primarily affects elderly individuals and has an extremely poor prognosis, with a median survival of 3–5 years after diagnosis [1]. The diagnosis of IPF is difficult and usually warrants the need for a multidisciplinary discussion (MDD) with a pulmonologist, radiologist and pathologist to make an accurate diagnosis [1]. Moreover, the disease course is complex and difficult to predict [2].
A lung function test is crucial to detect, diagnose and monitor the progression of IPF. Forcedvital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO) levels are considered as the most valuable parameters of lung function tests for the diagnosis of IPF [3]. The rate of FVC decline has been used as a marker for disease progression because of its association with mortality [4], and DLCO measures another physiological deficiency (gas diffusion) associated with lung fibrosis. DLCO was reportedly also associated with pulmonary hypertension, an important comorbidity of IPF. The GAP index that combines age, sex and FVC and DLCO findings can predict mortality. However, the abnormalities of lung function tests on IPF may be diversed. FVC and DLCO may not be equally affected. Lung function test results may be normal in some patients with clinical or pathological IPF [3].
High-resolution computed tomography (HRCT) of the chest is another key examination for IPF. The fibrotic patterns on HRCT are important clues to classify and diagnose IPF [1]. Recently, tools were developed to quantify the chest HRCT findings for the diagnosis of IPF; the findings may include the extent of pulmonary fibrosis and volume of the pulmonary vasculature. Despite technological advances, the association of HRCT findings with lung function tests in terms of the diagnosis of IPF is still not extensively investigated. Moreover, there is still no consensus on the relationship between CT findings, pulmonary vasculature, the extent of fibrosis and lung function. The limited number of studies on this topic did not report unanimous results [5,6,7,8]. Therefore, this study aimed to demonstrate the relationship between the extent of fibrosis, pulmonary vasculature and lung function of patients with IPF.
Methods
Patient selection
This retrospective study on human subjects was approved by the local ethics committee (The Institutional Review Board of MacKay Memorial Hospital, Taipei Branch, Taipei, Taiwan). From December 2019 to April 2021, 106 cases discussed during the MDD were enrolled for further investigation. The MDD was conducted in accordance with the guidelines laid down for the treatment of IPF [9]. The MDD committee comprised pulmonologists, rheumatologists, radiologists and pathologists. The discussion and the diagnosis were based on the diagnostic algorithm proposed in the guideline. Patients with a confirmed IPF diagnosis were included, whereas those who were (1) diagnosed with non-IPF diseases (including connective tissue disease-related interstitial lung disease [CTD-ILD], lymphangioleiomyomatosis [LAM], lymphocytic interstitial pneumonia [LIP], chronic hypersensitivity pneumonitis [CHP], sarcoidosis, infection/airway disease, etc.); (2) diagnosed with an indeterminate usual interstitial pneumonia (UIP) pattern; (3) having concurrent pulmonary malignancy (primary or secondary); (4) without pulmonary function test results within 3 months of the CT scan and (5) having acute disease exacerbation (according to clinical conditions and CT images) as well as (6) those who could not be diagnosed with IPF at the MDD were excluded from the study. This study was performed in compliance with the Declaration of Helsinki, and the study protocol was approved by the Institutional Review Board at Mackay Memorial Hospital, Taipei, Taiwan (no. 21MMHIS180e). Data were anonymously analysed.
CT scans revealing emphysema that was determined to more than mild based on the Fleischner Society classification system [10, 11] were also excluded because the pulmonary vasculature would be affected by the emphysema [9].
Clinical information
Patients’ characteristics (including age and gender) and pulmonary function tests (FVC, FVC%, DLCO and DLCO%) were recorded.
CT imaging protocols
All CT scans were performed using a 128-slice (Somatom Definition AS, Siemens Healthcare, Forchheim, Germany) or 256-slice (Somatom Definition Flash, Siemens Healthcare, Forchheim, Germany) multidetector computed tomography (MDCT) scanner. CT images for all patients were identical with the same imaging parameters: a collimation of 128 × 0.6 or 256 × 0.6 mm, tube voltage of 120 kVp, tube current modulation, the gantry rotation speed of 0.5 s/r and reconstructed slice thickness of 1.5 mm in one whole breath-hold. The scan coverage was from the lung apex to the lowest hemidiaphragm. All images were acquired in a supine position and at full inspiration.
Image analysis and lung function quantification
All the CT images were reviewed by two radiologists (W.H. and C.Y.) with 8 and 18 years of experience in examining chest CT images, respectively, who were blinded to information regarding the patients’ lung function. The fibrotic score ascertained made at six levels: 1) aortic arch, 2) 1 cm below the carina, 3) right pulmonary venous confluence, 4) halfway between the third and fifth section, 5) 1 cm above the right hemidiaphragm and 6) 2 cm below the right hemidiaphragm (Fig. 1) [12]. The proportion of the content with at least one of the following characteristics was scored to the nearest 5%: honeycombing, traction bronchiectasis, subpleural reticulation and ground-glass opacity with traction bronchiectasis in each section, and the fibrotic score was the average of the percentage in these six sections [13]. The short-axis diameter of the pulmonary artery (PA) trunk on axial sections of the mediastinal window at the PA bifurcation level was measured [14].
The principles of quantification for the lung, emphysema and vessel volumes
We adopted commercial software (QUIBIM Precision 2.8, QUIBIM SL, Valencia, Spain) for lung segmentation, vessel extraction and emphysema extraction based on several steps of image thresholding and classification. The first transformation in the raw data domain is a preliminary segmentation of lung parenchyma using − 450 HU as the threshold value. The lung classification step involves the use of distance and the watershed transforms to localize the plane that passes between both lungs for accurate lung separation (Fig. 2).
The vessel-volume extraction algorithm by QUIBIM Precision was adopted by the technology Frangi filter, which uses the eigenvalue decomposition and vectors of the local Hessian matrix of CT to discriminate between plane-, blob- and tubular-like structures of the lung vessels (Fig. 3). As lung vessels have different radii in the chest region, it is significantly important to accurately extract vessel structures in a multi-scale framework using the algorithms of the Hessian matrix and the vessel measurements developed by Frangi [15]. The accuracy of vessel-volume evaluation and calculation has been well validated by Frangi’s publication [15], which reports an excellent area under the curve of 0.978, specificity of 0.900 and sensitivity of 0.973 at an optimal threshold higher than 0.9 in almost all cases.
The pulmonary vascular volume (PVV) score was calculated based on the ratio of the vessel and total lung volume.
The methodology for lung emphysema quantification included segmentation and extraction using a fixed threshold of − 950 HU. Based on this methodology, all pixel intensity values below the fixed threshold were considered as emphysema, whereas pixel values above the threshold were considered lung parenchyma. Relative volumes in the percentage were computed as the ratio between the total absolute volume occupied by the structure divided by the total lung volume.
Statistical analysis
The correlation between lung function and CT parameters was examined using Spearman’s correlation. The lung function parameters, DLCO values and FVC values, were expressed as percentiles based on normal predicted values. The inter-rater reliability of the fibrotic score was assessed using the intraclass correlation coefficient (ICC). All tests were two-sided, and p-values of < 0.05 were considered statistically significant. The statistics were performed with R version 4.0.2 (R Foundation for Statistical Computing, Vienna, Austria).
Results
A total of 106 cases were included in the MDD from December 2019 to April 2021. Among them, 55 who were diagnosed with conditions other than IPF were excluded. Among the remaining 51 patients, 3 were excluded as they did not perform a lung function test within 3 months of chest HRCT, 11 due to moderate to severe emphysema, and 5 due to subtle lung fibrosis and lack of confidence in their diagnosis of IPF. Finally, 32 patients diagnosed with IPF in the MDD were selected for undergoing investigation (Fig. 2).
Basic characteristics
The basic characteristics of our population are presented in Table 1. Men accounted for 68.9% of the population, with a mean age of 74.7 (± 7.8) years, mean FVC (%) of 84.5% (± 22.5%) and mean DLCO of 63.0% (± 24.2%). CT parameters, including CT lung volume, PVVscore, fibrotic score and PA trunk diameter are also summarised in Table 1, which were 2959.3 (± 1047.1) cm3, 7.83 (± 3.01)%, 23.7 (± 10.9)% and 3.04 (± 0.46) cm, respectively.
Reproducibility of the fibrotic score
Fibrotic scores estimated through the chest CT were used to evaluate inter-rater reliability. A total of 32 chest CTs were evaluated by two radiologists. The intraclass correlation coefficient (ICC) and Bland–Altman plot were used to evaluate the reproducibility of the fibrotic scores. As the scores were not normally distributed, log transformation was performed. The Bland–Altman plot is illustrated in Fig. 4 with mean bias = 0.0035 (95%CI: − 0.072, 0.079), upper LOA = 0.43(95%CI: 0.30, 0.56) and lower LOA = − 0.42 (95%CI: − 0.29,-0.55). The ICC was 0.87 (p < 0.001). High reproducibility of the fibrotic score was demonstrated.
Correlation
The correlation between lung function and CT parameters was demonstrated in the correlation matrix (Table 2). The fibrotic score was correlated with the PVV score (r = 0.59, p < 0.001) and DLCO (r = − 0.59, p = 0.001) level. No significant correlation was observed between the fibrotic score and lung volume parameters, including FVC (r = − 0.20, p = 0.3), and CT lung volume (r = 0.09, p = 0.62) and PA trunk diameter (r = 0.19, p = 0.24). Apart from the fibrotic score, the DLCO levels were also significantly correlated with PVV score (r = − 0.43, p = 0.03). The correlation between the PVV score, fibrotic score and DLCO level is presented in Fig. 5. In addition, DLCO and FVC did not demonstrate a significant parallel trend (r = 0.36, p = 0.06), and FVC and CT lung volumes were concordant (r = 0.51, p = 0.005). Since the DLCO is composed of KCO and VA. The correlation of PVV score to KCO and VA was further explored. The PVV score did not correlate significantly to KCO (r = -0.30, p = 0.13). Instead, the VA correlated to PVV score significantly (r = -0.41, p = 0.03). The PA trunk diameter was significantly positively correlated with the PVV score (r = 0.47, p = 0.006) but not with FVC (r = − 0.11, p = 0.58) and DLCO (r = 0.22, p = 0.28) levels.
Discussion
This study was conducted to evaluate the relationship between the extent of fibrosis, pulmonary vasculature and lung function in patients with IPF. Our current findings may be twofold. The fibrotic score estimated through CT was significantly correlated with DLCO and PVV scores, but not with FVC levels. The DLCO was significantly correlated with the PVV score but did not reveal a parallel trend with the FVC.
In previous studies, the extent of fibrosis in MDCT was found to be correlated with DLCO and FVC levels [12, 16]. This discrepancy with our results may be attributable to two reasons. First, the study population of our study had preserved their FVC despite the fibrosis evident on the CT images; this may have led to an insignificant association between FVC and the extent of lung fibrosis. In contrast, the DLCO was found to have remarkably reduced in our study. It has been observed that the lung volume and DLCO levels may not always change in parallel in IPF [17, 18]. A proportion of patients with IPF had preserved their FVC but had remarkably lower DLCO levels. Moreover, DLCO levels can decline earlier and more seriously than FVC in patients with IPF [18]. Traditionally, a decline in FVC was used as the primary end-point in previous clinical trials [19,20,21]. Recent studies have reported that FVC alone cannot sufficiently define the severity of IPF and DLCO could shed light on another important physiological defect in IPF, which might be associated with the early diagnosis of fibrosis [22]. Second, the fibrotic score indicates the extent of pulmonary fibrosis but does not distinguish different fibrotic patterns. In Fraser et al. and Wells et al.’s studies, the extent of fibrosis more significantly correlated with DLCO than with FVC levels [12, 23]. These findings might reflect the fact that the influence of fibrosis on lung function is complex in IPF. The extent of fibrosis may have different impacts on FVC based on disease severity. Instead, it affected the DLCO more profoundly.
Jacob et al. reported that the PVV score was significantly correlated with the fibrotic score and DLCO using both CALIPER software and visual fibrotic score [16], which is concordant with our results. However, there were some distinct features of our study. Firstly, in our study, all subjects belonged to the same race (Taiwanese), and patients with moderate and severe emphysema were excluded. Furthermore, the diagnosis of all patients included in this study was confirmed by in the MDD. Through these processes, the well-known high heterogeneity of patients with IPF can be reduced. Finally, we did not find a correlation between PVV scores and FVC as the study of Jacob et al. It may be explained by the fact that PVV score reflected the extent of pulmonary fibrosis (fibrotic score) and the fibrotic score correlated with DLCO but not FVC in this study.
The cause of the correlation between the PVV and fibrotic scores remains unclear. Jacob et al. suggested that the high intrathoracic pressure generated by non-compliant fibrotic lungs dilates the pulmonary vasculature, which might lead to a high PVV score in the fibrotic lung. Contrary to Jacob et al.’s studies, neither PVV nor fibrotic scores were correlated with FVC in our study. FVC negatively reflect lung compliance in IPF [24]. Despite the lack of relevance to FVC, the correlation of the PVV score with fibrotic score remains robust in our study. To further explore the underline mechanism of the negative correlation between PVV score and DLCO, the correlation between PVV score, KCO and VA was performed. It was found that PVV score correlated significantly to VA (r = -0.41, p = 0.03) but not KCO (r = -0.3, p = 0.13). The negative correlation between PVV score and DLCO in IPF may be explained by the fact that the VA but not KCO was significantly decreased. The low VA may cause expanded PVV score (PVV score is the result of vascular volume divided by total lung volume) and reduced DLCO (DLCO is composed of VA and KCO). However, the effects of fibrosis on the lung vessel volume may be complex. It may be related to pulmonary hypertension, architectural distortion due to fibrosis or vasculature concurrent with fibrosis. Further studies are warranted to illustrate the pathophysiology responsible for the increased PVV score in IPF.
The PA trunk diameter was believed to indirectly reflect pulmonary arterial pressure (PAP) [25]. In our study, we found that the PA trunk diameter was significantly correlated with the PVV score (r = − 0.47, p = 0.006) but not with the fibrotic score (r = 0.19, p = 0.24). These findings were concordant with those of previous studies. Jacob et al.’s study also indicated the correlation of the PVV score with the right ventricular systolic pressure measured using echocardiography [16]. Fisher et al.’s study conducted using the right heart catheter to measure PAP also demonstrated that the extent of fibrosis was not associated with PAP in ILD [26]. Although the pulmonary vasculature changes in IPF are still not fully illustrated, a recent study indicated that the pathogenetic process of pulmonary fibrosis may also be responsible for vasculature changes [27]. Another study by Jacob et al. reported that a higher PVV score was related to increased fibrosis and higher mortality [8]. The PVV may be an important radiological marker for interstitial pneumonitis and needs further investigation to verify its significance in IPF.
In our study, FVC levels were found to be significantly correlated with CT lung volume. As the IPF is primarily a disease affecting elderly individuals, the lung function test may be too laborious for some, especially those with cognitive deficiencies [28, 29]. For patients with IPF who have difficulty performing lung function tests, the measurement of CT lung volume may be a possible surrogate to evaluate lung mechanics. As the decline in FVC was used as the physiological marker for disease progression and prognosis prediction, reduced CT lung volume may serve as a quantitative image marker for the same purpose.
This study has some limitations. First, the sample size was small. Most of the included patients did not have reduced FVC. Considering the disease heterogeneity in IPF, our study cohort may only represent a specific proportion of the IPF population (especially those with preserved FVC levels), and the result may not be applicable to all patients with IPF. Second, fibrotic score measurement is a semi-quantitative method that uses the average percentage of fibrosis at six levels on chest CTs to quantify the severity of fibrosis of the entire lung. Despite its high reproducibility among well-trained assessors (both in our study and previous studies), there is a limitation in using a few CT slices to represent the severity of fibrosis of the entire lung. Third, there is still potential to capture the misclassified reticular pattern score among the PVV in patients with extensive fibrosis. Fourth, this study did not obtain information on cardiac echography or right heart catheterisation. Therefore, an association between PA pressure, PA trunk diameter and pulmonary vascularity could not be further illustrated. Finally, because the lung function parameter is expressed by the percentile of expected values while considering the age, sex, body height and weight, a multivariable analysis of the basic characteristics was not performed. Furthermore, CT parameters including fibrotic score, PVV score, PA diameter and CT lung volume were correlated with each other. Considering the problems of collinearity, we could not perform a multivariate analysis of the CT parameters.
Conclusion
Our study demonstrates the extent of fibrosis and the association of PVV with DLCO but not with FVC levels among patients with IPF. The pulmonary trunk diameter indicated that the PAP was associated with PVV scores. This provides evidence of the structural (image findings of HRCT) and functional association (lung function test) in IPF.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- IPF:
-
Idiopathic pulmonary fibrosis
- HRCT:
-
High-resolution computed tomography
- PA:
-
Pulmonary artery trunk
- PVV:
-
Pulmonary vascular volume
- FVC:
-
Forced vital capacity
- DLCO:
-
Diffusing capacity for carbon monoxide
- MDD:
-
Multidisciplinary discussion
- CTD-ILD:
-
Connective tissue disease-related interstitial lung disease
- LAM:
-
Lymphangioleiomyomatosis
- LIP:
-
Lymphocytic interstitial pneumonia
- CHP:
-
Chronic hypersensitivity pneumonitis
- MDCT:
-
Multidetector computed tomography
- ICC:
-
Intraclass correlation coefficient
- PAP:
-
Pulmonary arterial pressure
References
Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, Behr J, Cottin V, Danoff SK, Morell F et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med 2018;198(5):e44–e68.
Flaherty KR, Kolb M, Vancheri C, Tang W, Conoscenti CS, Richeldi L. Stability or improvement in forced vital capacity with nintedanib in patients with idiopathic pulmonary fibrosis. Eur Respir J 2018;52(2):1702593.
Martinez FJ, Flaherty K. Pulmonary function testing in idiopathic interstitial pneumonias. Proc Am Thorac Soc. 2006;3(4):315–21.
Zappala CJ, Latsi PI, Nicholson AG, Colby TV, Cramer D, Renzoni EA, Hansell DM, du Bois RM, Wells AU. Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis. Eur Respir J. 2010;35(4):830–6.
Occhipinti M, Bosello S, Sisti LG, Cicchetti G, de Waure C, Pirronti T, Ferraccioli G, Gremese E, Larici AR. Quantitative and semi-quantitative computed tomography analysis of interstitial lung disease associated with systemic sclerosis: a longitudinal evaluation of pulmonary parenchyma and vessels. PLoS ONE. 2019;14(3): e0213444.
Hieba EG, Shaimaa EE, Dina SS, Noha AO. Diffusion lung capacity for carbon monoxide correlates with HRCT findings in patients with diffuse parenchymal lung disease. Egypt J Bronchol 2020;14(1):1–9.
Jacob J, Pienn M, Payer C, Urschler M, Kokosi M, Devaraj A, Wells AU, Olschewski H. Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: a structure-function study. Respirology (Carlton, Vic). 2019;24(5):445–52.
Jacob J, Bartholmai BJ, Rajagopalan S, Kokosi M, Nair A, Karwoski R, Walsh SL, Wells AU, Hansell DM. Mortality prediction in idiopathic pulmonary fibrosis: evaluation of computer-based CT analysis with conventional severity measures. Eur Respir J 2017;49(1):1601011
Matsuoka S, Washko GR, Dransfield MT, Yamashiro T, San Jose Estepar R, Diaz A, Silverman EK, Patz S, Hatabu H. Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation. Acad Radiol 2010;17(1):93–99.
Lynch DA, Austin JHM, Hogg JC, Grenier PA, Kauczor H-U, Bankier AA, Barr RG, Colby TV, Galvin JR, Gevenois PA, et al. CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society. Radiology. 2015;277(1):192–205.
Lynch DA, Moore CM, Wilson C, Nevrekar D, Jennermann T, Humphries SM, Austin JHM, Grenier PA, Kauczor H-U, Han MK, et al. CT-based visual classification of emphysema: association with mortality in the COPDGene Study. Radiology. 2018;288(3):859–66.
Fraser E, St Noble V, Hoyles RK, Benamore R, Ho L-P. Readily accessible CT scoring method to quantify fibrosis in IPF. BMJ Open Respir Res. 2020;7(1): e000584.
Goh NSL, Desai SR, Veeraraghavan S, Hansell DM, Copley SJ, Maher TM, Corte TJ, Sander CR, Ratoff J, Devaraj A, et al. Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med. 2008;177(11):1248–54.
Edwards PD, Bull RK, Coulden R. CT measurement of main pulmonary artery diameter. Br J Radiol. 1998;71(850):1018–20.
Jimenez-Carretero D, Santos A, Kerkstra S, Rudyanto RD, Ledesma-Carbayo MJ. 3D Frangi-based lung vessel enhancement filter penalizing airways. In: 2013 IEEE 10th International Symposium on Biomedical Imaging: 7–11 April 2013 2013; 2013: 926–929.
Jacob J, Bartholmai BJ, Rajagopalan S, Kokosi M, Nair A, Karwoski R, Raghunath SM, Walsh SL, Wells AU, Hansell DM. Automated quantitative computed tomography versus visual computed tomography scoring in idiopathic pulmonary fibrosis: validation against pulmonary function. J Thorac Imaging. 2016;31(5):304–11.
Cortes-Telles A, Forkert L, O’Donnell DE, Moran-Mendoza O. Idiopathic pulmonary fibrosis: new insights on functional characteristics at diagnosis. Can Respir J. 2014;21(3):e55-60.
Bermudo Peloche G, Suárez-Cuartin G, Rivera Ortega P, Rodriguez-Portal JA, Sauleda J, Nuñez B, Castillo D, Aburto M, Portillo K, Balcells E, et al. Preserved forced vital capacity is not always representing early IPF. Eur Respir Soc. 2020;56(suppl 64):765.
Noble PW, Albera C, Bradford WZ, Costabel U, Glassberg MK, Kardatzke D, King TE Jr, Lancaster L, Sahn SA, Szwarcberg J, et al. Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials. Lancet (London, England). 2011;377(9779):1760–9.
Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071–82.
Flaherty KR, Wells AU, Cottin V, Devaraj A, Walsh SLF, Inoue Y, Richeldi L, Kolb M, Tetzlaff K, Stowasser S, et al. Nintedanib in progressive fibrosing interstitial lung diseases. N Engl J Med. 2019;381(18):1718–27.
Robbie H, Daccord C, Chua F, Devaraj A. Evaluating disease severity in idiopathic pulmonary fibrosis. Eur Respir Rev 2017;26(145).
Wells AU, King AD, Rubens MB, Cramer D, du Bois RM, Hansell DM. Lone cryptogenic fibrosing alveolitis: a functional-morphologic correlation based on extent of disease on thin-section computed tomography. Am J Respir Crit Care Med. 1997;155(4):1367–75.
Plantier L, Cazes A, Dinh-Xuan A-T, Bancal C, Marchand-Adam S, Crestani B. Physiology of the lung in idiopathic pulmonary fibrosis. Eur Respir Rev. 2018;27(147): 170062.
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J. 2016;37(1):67–119.
Fischer A, Swigris JJ, Bolster MB, Chung L, Csuka ME, Domsic R, Frech T, Hinchcliff M, Hsu V, Hummers LK et al. Pulmonary hypertension and interstitial lung disease within PHAROS: impact of extent of fibrosis and pulmonary physiology on cardiac haemodynamic parameters. Clin Exp Rheumatol 2014;32(6 Suppl 86):S-109–S-114.
Barratt S, Millar A. Vascular remodelling in the pathogenesis of idiopathic pulmonary fibrosis. QJM. 2014;107(7):515–9.
Allen SC, Baxter M. A comparison of four tests of cognition as predictors of inability to perform spirometry in old age. Age Ageing. 2009;38(5):537–41.
Carvalhaes-Neto N, Lorino H, Gallinari C, Escolano S, Mallet A, Zerah F, Harf A, Macquin-Mavier I. Cognitive function and assessment of lung function in the elderly. Am J Respir Crit Care Med. 1995;152(5 Pt 1):1611–5.
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WJW conceptualised this study, analysed the data regarding the lung function and CT parameters and wrote the manuscript. WMH analysed the data regarding the CT parameters, obtained the fibrotic score and wrote the manuscript. CHL provided the technique consultation of the quantification of CT. CHY validated the fibrotic score, CT analysis, revised the manuscript and supervised this study. All authors read and approved the final manuscript.
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This study complies with the Declaration of Helsinki, and the study protocol was approved by the Institutional Review Board at Mackay Memorial Hospital, Taipei, Taiwan (no. 21MMHIS180e). Data were analyzed anonymously. The images in this study were obtained from de-identified data and the need for informed consent was waived during institutional board review.
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Wu, WJ., Huang, WM., Liang, CH. et al. Pulmonary vascular volume is associated with DLCO and fibrotic score in idiopathic pulmonary fibrosis: an observational study. BMC Med Imaging 22, 76 (2022). https://doi.org/10.1186/s12880-022-00803-8
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DOI: https://doi.org/10.1186/s12880-022-00803-8