Introduction

Burns are common, with the potential for considerable morbidity and mortality. Almost 29,000 patients were admitted to UK burn services between 2003 and 2007 [1]. Between 4 and 22% were admitted to intensive care from presentation [2] and successful management requires a team approach.

Pathophysiology of burn shock

Burn injury results in cardiogenic, hypovolaemic and distributive shock. The intravascular volume becomes depleted primarily due to increased capillary permeability and fluid shifts. Above 30% total body surface area (TBSA), only partial compensation can be achieved by fluid resuscitation due to a generalised reduction in sodium ATPase activity and disruption of the cellular transmembrane ionic gradient that persists for several days. Microvascular injury secondary to inflammatory mediators such as histamine, bradykinin, prostaglandins, leukotrienes, vasoactive amines, platelet activation products and complement allows protein loss into the interstitium. The intravascular colloid osmotic pressure falls and fluid escapes the vascular system. The result is a loss of intravascular fluid, electrolytes and proteins with rapid equilibration with the interstitial compartments. Clinically, this is manifested by hypovolaemia, haemoconcentration, oedema, reduced urine output and cardiovascular dysfunction. Adequate resuscitation from burn shock is a critical therapeutic intervention in burn management.

Fluid resuscitation

Appropriate fluid management is the foundation of acute burns management. Without early and effective treatment, burns involving greater than 15 to 20% TBSA will result in hypovolaemic shock [3]. Mortality is increased if resuscitation is delayed longer than 2 hours post burn injury [4]. The aim is to prevent the development of burn shock and to minimise disruption to physiologic parameters in the face of ongoing cellular and hormonal responses. Several formulae have been developed to optimise fluid delivery whilst preventing over-resuscitation and subsequent pulmonary oedema, and potentially compartment syndrome in unburned limbs or abdomen.

There is limited evidence regarding burns resuscitation. The Parkland formula is most widely used and is the current consensus formula. The original Parkland formula included an element of colloid resuscitation but this has been omitted since 1979 due to fears over worsening acute respiratory distress syndrome (ARDS). Whilst formulae are a useful guide, the prescription should be adjusted to each patient. Initial fluid resuscitation is often inappropriate: Collis and colleagues reviewed burn size estimation and fluid prescription in over 300 patients and found that, on average, patients received 150% of recommended fluid based on the emergency department TBSA estimation, increasing to 200% after TBSA estimation by the burn unit [5]. Baxter identified some patient groups who routinely required further fluid in addition to that described by the Parkland formula. These groups include patients with inhalation injuries, those with electrical burns and those receiving delayed resuscitation [6]. Both Holm and Csontos and colleagues have found evidence suggesting that the Parkland formula is not accurate for predicting fluid requirements and instead suggest other methods and monitoring to guide resuscitation [7, 8].

Base deficit and lactate have been shown to correlate with mortality and fluid resuscitation volumes [9, 10]. Physiologic manipulation, however, does not change outcome; correction of acidosis and restoration of cardiac function takes between 24 and 48 hours irrespective of the resuscitation used [11, 12]. It is important for clinicians to regularly review physiological parameters and resuscitation endpoints, particularly urine output. A urine output of 0.5 to 1 ml/kg/hour, as recommended by the American Burn Association, should be targeted in the adult patient whilst monitoring pulse, blood pressure and oxygen saturations [13]. There is a paucity of evidence indicating the ideal urine output during resuscitation. Certain situations, including electrical or crush injury with associated rhabdomyolysis, merit additional monitoring and fluid loading. A small study comparing permissive hypovolaemia using a haemodynamic-guided approach with retrospective controls who received the Parkland formula found a reduction of volume infusion (3.2 ± 0.7 vs. 4.6 ± 0.3 ml/kg/% burn, P < 0.001), a reduction in positive fluid balance (7.5 ± 5.4 vs. 12 ± 4.7 l/day, P < 0.05) and a significant reduction in Multiple Organ Dysfunction Score value (P = 0.003) with permissive hypovolaemia [14]. Currently, there is no reliable tool to guide burn shock resuscitation, which has implications for the detection of resuscitation endpoints. Reducing complications of over-resuscitation and under-resuscitation requires ongoing scrutiny from an experienced burn team.

Pruitt has described the phenomenon of excess fluid loading as fluid creep; this is commonly seen. He states that 'adequate resuscitation has been succeeded by fluid creep, producing excessive resuscitation in the apparent belief that if some fluid is good, lots of fluid will be even better' [15]. Fluid creep usually results from inaccuracies in calculating fluid requirement, from clinician inattention to reducing unnecessary fluid infusions, from the increased use of sedation and analgesic infusions, and from the excess administration of crystalloid in favour of colloid replacement - or a combination.

Fluid creep issues have led to re-evaluation of the use of colloid. In theory, colloid resuscitation may preserve plasma oncotic pressure, provide efficient plasma expansion and reduce tissue and pulmonary oedema. An early meta-analysis of burn patients concluded the use of colloids to be deleterious, where the odds ratio for mortality with human albumin solution (HAS) usage was calculated to be as high as 2.40 (95% confidence limits: 1.11, 5.19) [16]. This review evaluated only four trials involving burns, one of which showed an increase in mortality following the use of HAS. Goodwin and colleagues found colloid-resuscitated patients required less fluid than those who received crystalloid alone (2.98 vs. 3.81 ml/kg/% TBSA) and their haemodynamic parameters were improved during the 12-hour to 24-hour period but patients developed progressive accumulation of lung water up to 7 days post burn [17]. Mortality was higher in the colloid group (11/40) than in the crystalloid group (3/39) although these patients eventually died of causes not obviously related to fluid resuscitation.

A multicentre randomised control trial involving 42 burn patients found no increase in multiple organ failure rates or mortality following the administration of 5% HAS for burn shock resuscitation [18]. Cochran and colleagues completed a retrospective analysis of patients who received albumin resuscitation compared with a control group who did not receive albumin [19]. After controlling for age, TBSA of burn and inhalation injury, albumin resuscitation did not significantly reduce mortality (odds ratio = 1.90, 95% confidence interval = 0.85 to 4.22). HAS is available at 5% and 20% formulations, and there is insufficient evidence to determine which might be most appropriate. Some consider the two formulations to be radically different and maintain that a study on 20% albumin in burns resuscitation is sorely needed.

There continues to be no consensus regarding the timing of colloid initiation. Fluid extravasation has been shown to stop by 8 to 12 hours, and Holm believes there is no evidence to indicate the need to delay colloid administration beyond this. Early colloid actually appears to have a pulmonary volume-sparing benefit [7]. O'Mara and colleagues randomised patients to either a plasma or crystalloid-only resuscitation group, using the Parkland formula to calculate initial fluid requirements and measured intra-abdominal pressures [20]. Although they did not find an improvement in overall outcomes using plasma resuscitation, they did show a reduction in overall fluid loading and significantly lower intra-abdominal pressures (26.5 vs. 10.6 mmHg, P < 0.0001) in the plasma-treated group.

Hypertonic saline is an alternative to colloid, potentially reducing fluid shift to the interstitium. A doubling in mortality has been reported as well as a fourfold increase in renal failure, but a Cochrane Review was unable to ascertain whether there was any effect on patients with trauma, with burns or undergoing surgery due to lack of data [21, 22]. Hypertonic saline is rarely used in our routine practice.

Currently, there is emerging evidence favouring routine use of colloid in managing burn shock. Colloid may reduce oedema-related complications and fluid creep particularly in those with increasing fluid requirements during resuscitation. Further studies are required to determine the most appropriate colloid, formulation and timing for its use.

Pharmacological resuscitation

There are no pharmacological agents currently in wide-spread clinical use. Attempts to reduce the severity of burn shock by blocking some of the chemical mediators of acute inflammation have been made with some success in clinical burns resuscitation. Such agents include hydralazine (a vasodilator), ketanserin (serotonin antagonist), hydrocortisone and ibuprofen (anti-inflammatory agent). Interestingly, a randomised prospective study involving 37 patients where vitamin C was given in ultra-high doses reduced fluid requirements by 40% in burn shock and significantly reduced the ventilation time (21.3 vs. 12.1 days, P < 0.05) [23].

Transfusion, coagulation and blood products

The Transfusion Requirements in Critical Care study by the Canadian Clinical Trials Group prospectively randomised critically ill patients to a restrictive strategy of red cell transfusion (maintenance of haemoglobin at 7 to 9 g/dl) or a liberal strategy (maintenance of haemoglobin at 10 to 12 g/dl). Unfortunately this study excluded burns. The study found the restrictive strategy to be at least as effective as a liberal strategy with the possible exception of patients with acute myocardial infarction and unstable angina [24]. Following a multiple-centre cohort analysis highlighting an increased mortality associated with blood transfusion, there is increasing implementation of a restrictive transfusion strategy [25].

Implementation of a restrictive transfusion policy appears to have not adversely affected outcome in paediatric or adult burn patients [26, 27]. Palmieri and colleagues undertook a study evaluating the effects of transfusion on outcome and revealed that the mean haemoglobin level in patients receiving their first unit of blood was significantly lower outside the operating theatre (8.9 vs. 10.2 g/dl, P < 0.05), which is higher than that perceived in medical practice (8.1 g/dl) [25, 28]. Nonsurvivors received significantly more blood transfusions than survivors (17.9 vs. 13, P < 0.05). This association was found after adjusting for multiple variables including burn size using multi-logistical regression. Patients with larger transfusions and poorer outcomes also had larger burns so increased transfusion requirements may simply be a surrogate marker for the severity of burn injury. In addition, the total number of units transfused correlated with the number of infectious episodes (Spearman rank correlation = 0.647; P < 0.01) [25]. A prospective, randomised trial of restrictive (7 to 8 g/dl) versus liberal (9 to 10 g/dl) blood transfusion policy in burns >20% TBSA is currently being undertaken by the American Burn Association.

The burn patient will intermittently need surgery that may need large or massive transfusion, and sets the burn patient apart from the more general critical care patient. Red cells facilitate haemostasis through a rheological effect by pushing platelets to the periphery of the vessel lumen to better interface at the endothelium as well as through direct effects on platelet biochemistry. Haematocrit <30% can therefore lead to significant extra blood loss [29].

Transfusion requirements also need to reflect the surgical and rehabilitation plan. If a large burn excision requiring major transfusion is planned, the patient needs to be optimised for theatre and a low starting haemoglobin concentration seems unwise. If patients are entering the rehabilitation phase, anaemia compromising relevant activities should be avoided: the consequences of delayed or impaired rehabilitation are profound in this patient group.

There has been considerable attention on the use of tranexamic acid to minimise perioperative blood loss and transfusion requirements. However, whilst the popularity of this strategy has increased - including anecdotally in burns - the randomised controlled trials to prove conclusive benefit do not exist in the burns literature.

Inhalation injury

Airway management and ventilator support are often instigated early in patients with severe burns. Respiratory failure in these patients may be multifactorial. Primary injury to the lungs and upper airway occurs due to direct thermal inhalation injury. Secondary injury can occur early, following activation of the systemic inflammatory response, or later, following the development of sepsis. Any pulmonary injury can be exacerbated by ventilator-associated lung damage. Full thickness chest or abdominal wall burns can result in poor compliance and high inspiratory pressures.

Smoke inhalation injury occurs via several different mechanisms not just direct thermal injury to the respiratory tract mucosa. The type of injury sustained depends upon factors including the patient's underlying respiratory function, the properties (water solubility) of the fumes inhaled and the extent of exposure. The exact pathophysiology of lung injury following smoke inhalation injury is unclear. The classic complement cascade is thought to be activated, followed by intrapulmonary leukocyte aggregation and oxygen free radical release resulting in pulmonary oedema [30]. Nitric oxide inhibits hypoxic vasoconstriction and is a key component of the inflammatory cascade, giving rise to vasodilatation, ventilation/perfusion mismatch and diminished transpulmonary oxygen transfer [31, 32].

In addition to the ongoing inflammatory cascades, casts formed from cellular debris, fibrin clots, polymorphonuclear leucocytes, mucous, mucin B5 and airway oedema are likely to cause airway obstruction contributing to respiratory failure [31–36]. Partially obstructed airways can lead to air trapping and hyperinflation. This overdistention leads to release of a neutrophil chemo-attractant, IL-8. Following activation, neutrophils produce superoxide that reacts with nitric oxide and causes endothelial damage and increased vascular permeability. Coagulation factors within the exuded plasma, tissue factor released from pulmonary epithelial cells and alveolar macrophages initiate the extrinsic coagulation cascade with resultant fibrin deposition in the alveolar space - a hallmark of smoke inhalation-induced acute lung injury. Fibrin also has an inhibitory effect on surfactant, further compounding alveolar collapse.

Systemic toxins such as hydrogen cyanide can be a significant cause of mortality, characterised by signs of hypoxia despite adequate arterial oxygen tension. Various agents such as nitrates and hydroxycobalamin have been used, but some are themselves toxic, and there is little evidence from randomised trials to support their routine use. Carbon monoxide levels higher than 15 to 20% should be treated with 100% endotracheal oxygen. There is little consensus regarding parameters or indications for hyperbaric oxygen, and availability is limited [37].

Ventilatory strategies

In the general intensive therapy unit, the incidence of ventilator-associated lung injury has been reduced following introduction of lung-protective ventilator strategies using low tidal volumes and permitting a degree of hypercapnia [38]. Other adjunctive strategies, including maintenance of high positive end-expiratory pressure and prone positioning, have not shown any beneficial effect on outcome [39, 40].

High-frequency oscillatory ventilation (HFOV) is an unconventional form of mechanical ventilation that is increasingly being used in the management of oxygenation failure in adult ARDS. There is limited information regarding the use of HFOV following inhalation injury [41–43]. The unique features of smoke inhalation-induced lung injury may limit the use of HFOV: distal alveolal recruitment may be limited by small airways obstructed with carbonaceous debris, oedema and sloughing mucosa; gas trapping and associated hypercapnia may be difficult to manage with HFOV; and management of secretions can be problematic. The use of HFOV also makes the use of nebulised therapies and therapeutic bronchoscopy impractical. Cartotto and colleagues retrospectively reviewed patients with ARDS after smoke inhalation and those with burns without an inhalational injury that received rescue HFOV for ARDS-related oxygen failure [42]. Patients with an inhalational injury did not achieve a significant improvement in the partial pressure of oxygen/fractional inspired oxygen ratio until 72 hours of HFOV therapy, contrasting with those without an inhalational injury where there was a significant improvement in oxygenation within 8 hours. However, there was no predefined HFOV protocol and there were significant baseline differences between the groups, including timing of HFOV initiation and pre-HFOV positive end-expiratory pressure.

There are no studies to assess the use of HFOV as an early strategy in acute lung injury after thermal inhalation. Further prospective randomised control trials with well-defined strict protocols are required to guide usage of HFOV in ARDS following inhalation injury.

Tracheostomy

Evidence suggests percutaneous tracheostomy is safe in burn patients, but caution should be employed in those with severe head and neck burns or upper airway oedema because airway loss could result in serious complications [44]. Burn surgeons are experienced at these challenging tracheostomies and coordination of tracheostomy (closed or open) with grafting of the neck requires close communication with the surgeon. A retrospective review of adult patients following severe burn injury found patients with tracheostomy had a significantly shorter time to extubation; however, there was no difference in ventilator support, pneumonia prevalence, length of stay or mortality [45]. As with nonburn patients, there is no consensus as to the optimal timing of tracheostomy. Saffle and colleagues found no advantage in early tracheostomy [45], but there may be increased benefit in children [46]. Early tracheostomy is likely to benefit most those with major burns plus significant inhalation injury because they will require numerous surgical procedures and prolonged ventilation, and respiratory sepsis is almost inevitable.

Pharmacologic ventilatory adjuncts

Studies in burned animals and humans have revealed multiple possible therapeutic effects of glycosaminoglycans for thermal injury. Heparin reduces airway obstruction by potentiating antithrombin-III-mediated inactivation of thrombin and possibly by acting as a free radical scavenger. Multiple studies have shown intravenous and nebulised heparin to be effective [47]. Tissue plasminogen activator and antithrombin have comparable effects to heparin [47, 48]. A small, retrospective, single-centre study with 30 patients using historical controls receiving the same ventilatory strategy found a 38% reduction in mortality (number needed to treat 2.7) and reduced lung injury scores when nebulised unfractionated heparin, N-acetylcysteine and albuterol sulphate were administered in comparison with albuterol sulphate alone [49]. A paediatric case series with historical controls found a significant reduction in mortality, incidence of atelectasis and reintubation rate in the group treated with an alternating regime of aerosolised heparin alternating with 20% N-acetylcysteine solution [50]. A multicentre, prospective trial is needed to confirm this finding.

Nitric oxide has been used in burn patients to treat hypoxic pulmonary vasoconstriction and to improve ventilation/perfusion mismatches and therefore tissue oxygenation [51, 52]. However, Enkhbaatar and colleagues have shown there is an increase in nitric oxide levels in lung tissue secondary to inhalation injury and that the resultant loss of hypoxic vasoconstriction worsens ventilation perfusion mismatch [53]. They examined the use of BBS-2 (intrinsic nitric oxide synthase inhibitor) on sheep and reported an improvement in pulmonary gas exchange and shunt fraction. The use of pharmacological adjuncts for the management of inhalation injury remains limited by the lack of commercial availability of some agents, a lack of human trials and confounding experimental results.

Sepsis

Following severe thermal injury, patients exhibit physiologic and metabolic responses with resultant persistent tachycardia, tachypnoea and rise in baseline core temperature. Virtually all patients therefore meet the criteria for the systemic inflammatory response syndrome, resulting in little discriminative value in the burn patient. The American Burn Association has produced consensus guidelines suggesting modified definitions for utilising the systemic inflammatory response syndrome criteria in burn patients (Table 1) [54]. Other reliable markers of diagnosing sepsis are required. Those markers most commonly used include white cell count, C-reactive protein and erythrocyte sedimentation rate. More recently, procalcitonin has been described as a useful marker for sepsis in burn patients and in some studies has been found to be superior to C-reactive protein [55–58]. In the paediatric setting, however, procalcitonin lagged behind clinical diagnosis by 0.8 days and was less useful than C-reactive protein [59].

Table 1 American Burn Association suggested definitions for utilising systemic inflammatory response syndrome criteria in burn patients
Full size table

Sepsis prevention is critical in the management of the severely burned patient. In addition to standard infection control measures, early excision and skin grafting is now accepted practice. A meta-analysis comparing early excision and conservative management with late grafting identified six studies that met their inclusion criteria. Two of these studies used sepsis as an outcome measure but used different definitions of sepsis, making comparison difficult. One study showed the early excision group required a shorter duration of antibiotic therapy and had fewer positive wound cultures [60].

Split skin grafting may be limited by the availability of donor sites in extensive burns. In this case, wound care should be optimised with a dermal substitute or appropriate dressing. Silver is a broad-spectrum antimicrobial whose properties are utilised by a number of topical preparations and dressings. Meshing of autografts allows for greater wound cover whilst limiting the donor area. Cadaveric allograft, often in combination with autograft in a sandwich technique, is seen by many as the best available temporising measure and grafts retain immunological function. The huge expense of allograft and its preorder for surgery adds another dimension for communication between intensivists, anaesthetists and surgeons lest product is wasted.

In adults, there is no role for prophylactic antibiotics unless utilised for wound excision or manipulation procedures due to the risks of adverse events and anti-microbial resistance. A systematic review and meta-analysis found a potential benefit of prophylactic antibiotics in burn patients but from data of poor methodological quality [61]. Selective decontamination of the digestive tract (SDD) in burns is generally supported by a small number of studies: a double-blind randomised control trial of 117 adult burn patients showed a significant reduction in both mortality and pneumonia in the treatment group with respect to placebo without adverse effects [62]. A recent meta-analysis of the three published SDD randomised control trials in burn patients, recruiting 440 patients (289 SDD patients, 151 controls), confirmed that SDD significantly reduced mortality by 78% (P < 0.001) [63]. Other studies have found a reduction in wound colonisation with the administration of SDD [64, 65]. A small paediatric randomised control trial did not find any significant differences in rates of colonisation, pneumonia or sepsis [66].

Burns sepsis needs rapid recognition and treatment with appropriate antibiotics, guided where available by microbiological results. Large burns are associated with fungal colonisation and infection so additional investigation and antifungals may be required. Multidrug-resistant organisms are becoming an increasing problem in the burn care setting. Topical antibiotics may offer some efficacy against these organisms and can be used in conjunction with systemic antimicrobials. Alternatively, drugs with less well tolerated profiles may be required, such as colistin for the treatment of multi-resistant acinetobacter species.

The pharmokinetics of many drugs can be altered due to the physiologic changes following major burns. Altered pharmokinetics of major antibiotic classes can result in subtherapeutic levels of the drug [67, 68]. Consideration should be given to reduced dosing intervals or the use of continuous infusions guided by appropriate monitoring, to ensure therapeutic plasma levels.

There is limited evidence to support routine use of corticosteroids in burn patients with sepsis [69, 70]. The Surviving Sepsis Campaign recommends intravenous hydrocortisone should be used in patients with septic shock only if they are poorly responsive to both fluid resuscitation and inotropic support because there is a paucity of evidence showing a reduction in mortality plus the possibility of a higher incidence of secondary infection [71].

There remains controversy regarding the use of immune-enhancing dietary supplements. Studies have reported variable results following the use of glutamine supplementation. Current evidence from nine randomised control trials supports the use of enteral glutamine supplementation for patients with severe burn injuries [72]. Improvements were seen in wound healing, gut permeability, length of stay and mortality but there was heterogeneity between studies in both methodology and reporting. Further investigation is required to answer questions regarding dosage, timing, and length of supplementation. Research to date has provided insufficient evidence to support the use of other immunonutrients such as fish oil or arginine. Currently, there are no clinically approved topical immunomodulators available for the burn patient.

Nutrition and hyperglycaemia

Patients following a severe burn injury are hypermetabolic with resultant protein loss and reduction in lean body mass and hyperglycaemia through some of the same mechanisms as other critically ill trauma patients. Whilst the hypermetabolic state provides glucose to glucose-dependent tissues, it ultimately contributes to immune dysfunction, sepsis and organ failure. Holm and colleagues identified increased adverse outcome in adults following hyperglycaemia in the first 48 hours post injury [73]. The paediatric burn literature showed that hyperglycaemia is associated with increased catabolism, bacteraemia/fungaemia, skin graft loss and mortality whilst intensive insulin therapy was associated with survival [74–78].

The Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation Investigators assessed glucose targets in a mixed ICU population, using intensive insulin control versus conventional insulin control (4.5 to 6 vs. 8 to 10 mmol/l) in more than 6,000 patients and reported lower mortality in the conventional group (24.9 vs. 27.5%, P = 0.02) [78]. Following subgroup analysis, however, the trauma group (not stipulated whether this included patients with burns) benefited from tight glycaemic control. Control of hyperglycaemia can be difficult in burn patients and intensive insulin treatment can lead to a higher risk of hypoglycaemia, which can be compounded by frequent trips to theatre and breaks in enteral feed [79]. Cochrane and colleagues evaluated an intensive insulin protocol (aiming to maintain glucose <12 mmol/l) in 30 patients, 17 with burns and 13 with soft tissue infections [80]. They experienced a 5%/day rate of hypoglycaemic episodes (glucose <6 mmol/l) but reported no neurological sequelae or deaths. Studies examining the effect of tight glycaemic control in burns are limited, but mortality benefits as evidenced by Van den Berghe and colleagues [81] and others has led to the control of hyperglycaemia becoming a standard of care.

Insulin has additional immunomodulatory effects beyond increasing cellular uptake of glucose. Insulin has a trophic effect on mucosal and skin barriers, reducing bacterial invasion and translocation, improves wound matrix formation and inhibits the production of proinflammatory mediators.

Failure to satisfy the nutritional requirements of the hypermetabolic burn patient will lead to impaired wound healing, susceptibility to infection, organ failure and death [82–85]. A host of formulae to calculate calorific needs are used, and various feeding formulations are available. In general, the evidence greatly favours enteral to parenteral nutrition in relation to outcome measures and cost.

Nasogastric and nasojejunal feeding each have their proponents, with the advocates of duodenal feeding citing the ability to continue feed during surgical procedures without risk of aspiration, although reduced aspiration with intestinal feeding has not been proven [86, 87].

Duodenal placement remains a challenging and inexact science requiring assistance with some imaging modality, but technological advancements have aided this at the bedside and many centres are moving towards jejunal feeding whether by fashion or evidence. Pro-motility agents such as erythromycin are often employed to assist maintenance of tubes in the correct location. High-quality evidence in many areas of nutrition remains very limited.

The combination of aggressive fluid resuscitation, early enteral feeding and proton pump inhibitors has reduced the incidence of acute gastrointestinal ulceration (Curling's ulcer) from 15% to 3% with a sizeable decrease in mortality from former death rates of 70% [88].

Hypermetabolism

Burn-induced catabolism results in accelerated protein breakdown and reduced protein synthesis, culminating in a negative net nitrogen balance. Demling and DeSanti reported that oxandrolone (an oral anabolic agent) improved weight gain and was an unquantified measure of muscle function [89], and in a later study showed a reduction in weight loss, urinary nitrogen loss and a shortened time to wound healing [90]. A prospective multicentre randomised double-blind trial of 81 patients with burns of 20 to 60% TBSA found that starting enteral oxandrolone 5 days post injury significantly reduced the hospital stay (45.3 vs. 32 days, P = 0.035) without significant adverse events [91].

The hypermetabolic response is in part mediated by endogenous catecholamines: shortly after severe burn or trauma, plasma catecholamine levels can increase up to 10-fold [92]. β-blockade following severe burns can reduce supraphysiologic thermogenesis, tachycardia, cardiac work and resting energy expenditure. Herndon and colleagues conducted a prospective randomised control trial in paediatric patients with severe burns to evaluate the effect of propanolol on muscle catabolism [93]. The net muscle-protein balance increased by 82% from baseline values in the propanolol group (P = 0.002) and was significantly higher with respect to the control group (P = 0.001). The mechanism of action of propanolol remains unclear but appears to be a result of increased protein synthesis during a period of persistent protein breakdown and reduced peripheral lipolysis [94].

Acute kidney injury

Acute kidney injury (AKI) is common following a burn injury with an incidence as high as 30% but is associated with a reported mortality of between 80 and 100% [95–97]. When defined by the Risk, Injury, Failure, Loss and End-stage kidney classification [98], AKI occurred in one-quarter of patients with severe burn injury (median mortality of 34.9%); and when defined by the need for renal replacement therapy, AKI occurred in 3% (median mortality of 80%) [99]. Mortality increases in a stepwise fashion with increasing Risk, Injury, Failure, Loss and End-stage class [95, 100]. Steinvall and colleagues reported approximately one-half of patients, particularly those with a severe burn injury, developed AKI during the first week post injury and the remaining patients during the second week [101]. In the majority of these patients, AKI was preceded by other organ dysfunction or sepsis. The burn shock resuscitation protocol used was successful at preventing early hypovolaemic AKI. This suggests that renal ischaemia, at least in the acute phase of burn shock, has a limited role in the development of AKI. Mosier and colleagues reported that both patients with or without an AKI averaged a urine output within the recommended 0.5 to 1.0 ml/kg/hour or greater; however, those who developed early AKI had a significantly lower average urine output (0.6 vs. 1.16 ml/ kg/hour, P < 0.01) [102].

A study looking at acute respiratory dysfunction in patients with major burns revealed that ARDS occurs early, usually within 3 days, and that renal dysfunction was more common amongst those with the most severe respiratory dysfunction [103]. In sepsis, there is increasing evidence to suggest that inflammation and apoptosis play a key role in the aetiology of AKI [104] - the literature in burns is limited. Late-onset AKI has been strongly associated with sepsis in the past [105]. A recent prospective cohort study found septic episodes were not always followed by renal dysfunction and two-thirds of late-onset AKI was not preceded by sepsis [101]. The development of intra-abdominal hypertension and abdominal compartment syndrome following over-resuscitation may contribute to AKI of later onset. Exposure to nephrotoxic antibiotics and intravenous contrast may also have a role.

Aggressive utilisation of continuous renal replacement therapy (50.2 ± 13.2 ml/kg/hour) in severely burned casualties with AKI significantly improved survival [106]. A recent study of patients with severe burn injury defined as TBSA >40% with AKI treated with continuous venovenous haemofiltration with a maintenance dose of 20 to 35 ml/kg/hour compared with historical controls prior to the availability of continuous venovenous haemofiltration found the use of continuous venovenous haemofiltration to be associated with a reduction in 28-day stay (38 vs. 71%, P = 0.011) and hospital mortality (62 vs. 86%, P = 0.04) [107]. Significant clinical improvements were seen in those with respiratory dysfunction and shock. The American Burn Association's randomised controlled evaluation of haemofiltration in adult burn patients with septic shock and acute renal failure (RESCUE) is currently recruiting patients as of May 2013.

Conclusion

Regional burn centres have developed to address resource requirements and the complexity of burn care. There have been significant improvements in outcome following burn injuries in the latter half of the 20th century, reflecting advances in critical care - in particular, following the introduction of fluid resuscitation protocols, early burn excision and closure, antimicrobials and infection control, nutritional support and modulation of the metabolic response. These improvements in care have resulted in the majority of patients outside extremes of age treated in a modern burn centre being expected to survive [108]. The US national burn repository with reports submitted from 91 hospitals showed that the length of stay has reduced in the past 10 years from approximately 11 days to 9 days, and mortality has fallen in females from 6.8% to 3.6% and in males from 4.5% to approximately 3% [109].

Recent evidence suggests the routine use of colloid resuscitation and permissive hypovolaemia to reduce fluid creep and its attendant complications. Whilst many strategies including oxandralone have been utilised successfully to attenuate the hypermetabolic response, further studies are required to assess their safety and appropriate use. Currently, β-blockade using propanolol appears to be the most efficacious anti-catabolic therapy. At the Mersey Regional Burn Centre we have adopted the routine use of oxandrolone and have a fluid resuscitation protocol based on the Parkland formula but modified to 2 to 3 ml/kg/% burn with albumin rescue [110]. Burns management is a rapidly evolving field with 8,000 burns-related articles in the last 10 years as compared with 11,000 in the last 90 years, with numerous studies underway that will hopefully provide further guidance for the management of these critically ill patients.