Avoid common mistakes on your manuscript.
Introduction
The scientific information on biological activity of ceria dioxide nanoparticles (CeO2, nanoceria) is still very fragmentary. It is known, that nanoceria interaction with biological systems is based on two principal properties of this substance: low toxicity and high reducibility [1]. These factors determines activity of nanoceria in biological redox processes, especially in inactivation of reactive oxygen species, including free radicals that are formed inside living cells.
The aim
of the study was to assess the perspectives of nanoceria for various biomedical applications.
Methods
We have performed series of studies to investigate the biomedical effects of nanoceria in vitro and in vivo. Effectivity of ceria nanoparticles after UV-irradiation was determined by the analysis of L929 and VERO cells Viability State of the cells were visualized under UV microscope using fluorescent Hoechst and Propidium iodide dyes. Investigated the effects on reproduction nanoceria VSV (RNA-) and HSV-1 (DNA-) viruses, the viability of E.coli, S.aureus and C.albicans. We studied the effects of nanoceria doxorubicin-induced ultrasonography guided cardiomyopathy model and on the reproductive system of older animals.
Results
We estimated that 1, 25 mM colloid ceria solutions are capable to protect L929 and VERO cells from the damage induced by UV-irradiation [1, 2]. Nanoceria could be used not only as UV-blocking material, but also as prophylactic and even therapeutic compound for treatment sunburns. We consider that nanoceria inhibits the reproduction of the studied RNA-and DNA-viruses in and demonstrates a significant virucidal effect [3], reducing the virus titer in the investigated model systems. We have shown the antibacterial activity for gram-positive microorganisms and expressive antifungal action [4]. Course reception of nanoceria by older laboratory animals (mice / rats) causes improvement in the viability of germ cells in males increases the level of testosterone in the blood, protect ovarian cells against oxidative damage [5], demonstrating anti-aging properties. Application of nanoceria against doxorubicin-induced cardiomyopathy on reliable model [6] can remove the drug-induced oxidative stress, restoring the broken functionality of the body.
Conclusion
The application of nanoceria under conditions of involving oxidative stress can reduce / remove its damaging effects, thus providing protecting the organism from adverse environmental factors: UV irradiation, viral, bacterial, fungal lesions induced toxic effects and pathological conditions associated with aging.
Outlook and expert recommendations
The biomedical effects of nanoceria offer the prospect of its use as a UV protectant, a drug with antiviral, antibacterial and antifungal activity, as well as means capable of reducing the level of oxidative stress in cardiomyocytes in reproductive organs during aging.
References
Shcherbakov AB, Ivanov VK, Zholobak NM, Ivanova OS, Krysanov EIu, Baranchikov AE: Nanocrystaline ceria based materials-perspectives for biomedical application. Biofizika. 2011, 56 (6): 995-1015.
Zholobak NM, Ivanov VK, Shcherbakov AB, Shaporev AS, Polezhaeva OS, Baranchikov AYe, Spivak NYa, Tretyakov YuD: UV-shielding property, photocatalytic activity and photocytotoxicity of ceria colloid solutions. J. Photochem. Photobiol. B. 2011, 102: P32-38. 10.1016/j.jphotobiol.2010.09.002.
Zholobak N, Sherbakov A, Ivanov V, Olevinskaya Z, Spivak N: Antiviral effectivity of ceria colloid colutions Antiviral Research. Twenty-Fourth International Conference on Antiviral Research. 2011, Sofia, Bulgaria, 90 (2): A67-
Babenko LP, Zholobak NM, Shcherbakov AB, Woychuk SI, Lazarenko LM, Spivak MYa: Antimicrobial action of the ceria colloid solution on opportunistic microorganisms in vitro. Mikrobiol. 2012, 74 (3): 54-62.
Spivak Ya, Shepel EA, Zholobak NM, Sherbakov AB, Antonovitch GV, Yanciy RV, Ivanov VK, Tretyakov YuD: Ceria nanoparticles boost activity of aged murine oocytes. NanoBiomed Eng. 2012, 4 (4): 188-194.
Bubnov RV: The Use of Ultrasound Equipment of General Use for In Vivo Study of Cerium Dioxide Nanoparticles Introduction in Mice. Ultrasound Med Biol. 2011, 37 (8): S162-Suppl. 1
Author information
Authors and Affiliations
Corresponding author
Additional information
Nadiya M Zholobak contributed equally to this work.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Zholobak, N.M., Sherbakov, O.B., Babenko, L.P. et al. The perspectives of biomedical application of the nanoceria. EPMA Journal 5 (Suppl 1), A136 (2014). https://doi.org/10.1186/1878-5085-5-S1-A136
Published:
DOI: https://doi.org/10.1186/1878-5085-5-S1-A136