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A phthalimide-based ESIPT fluorescent probe for sensitive detection of Cu2+ in complete aqueous solution

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Abstract

A novel fluorescence-enhanced probe 2-butyl-1,3-dioxoisoindolin-4-yl picolinate (BDIP) has been developed for the detection of Cu2+ based on the excited-state intramolecular proton transfer (ESIPT) process. BDIP utilized a phthalimide derivative as the fluorophore and selected picolinate ester as the recognition site for Cu2+. The probe displayed high selectivity, strong anti-interference ability, and a significant fluorescence enhancement effect for Cu2+ in phosphate buffer saline (PBS, 10 mM, pH 7.4) with the detection limit of 31 nM. BDIP also possesses the advantages of simple synthesis steps, large Stokes shift, and good water solubility. Moreover, BDIP was used for Cu2+ detection in real water samples, with the result being satisfactory.

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Acknowledgements

This research was financially supported by the Shandong Provincial Natural Science Foundation (ZR2020MB107), the State Key Laboratory of Natural and Biomimetic Drugs (K20180201), the NSFC cultivation project of Jining Medical University (JYP2019KJ11), and the Supporting Fund for Teachers' research of Jining Medical University (JYFC2019KJ042).

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Jining Medical University, Rizhao, 276826, China

    Xiao Sheng, Lingdong Kong, Jun Wang, Lin Ding, Zhaoming Liu & Shouxin Wang

  2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China

    Shouxin Wang

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  1. Xiao Sheng
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  2. Lingdong Kong
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  3. Jun Wang
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  4. Lin Ding
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  5. Zhaoming Liu
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Correspondence to Shouxin Wang.

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Sheng, X., Kong, L., Wang, J. et al. A phthalimide-based ESIPT fluorescent probe for sensitive detection of Cu2+ in complete aqueous solution. ANAL. SCI. 38, 689–694 (2022). https://doi.org/10.1007/s44211-022-00084-9

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  • DOI: https://doi.org/10.1007/s44211-022-00084-9

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