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Outcomes of Debridement, Antibiotics and Implant Retention (DAIR) for Periprosthetic Joint Infection in a High-Volume Arthroplasty Centre

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Abstract

Purpose

Prosthetic joint infection (PJI) following total knee arthroplasty (TKA) and total hip arthroplasty (THA) can be a devastating diagnosis. Debridement, antibiotics and implant retention (DAIR) is a preferred treatment modality for acute PJI. A retrospective analysis of infected primary arthroplasties to evaluate the success of DAIR and factors influencing its outcomes.

Methods

We retrospectively reviewed all patients who underwent DAIR for PJI at our unit between 2010 and 2018. Patients who underwent revision surgery as an index procedure, arthroscopic washout and those with less than two years of follow-up were excluded. Treatment failure was defined as revision arthroplasty for recurrence of infection within 2 years of the index procedure. Chi-square and Fischer’s exact test were used to compare between patient factors and DAIR outcomes. Kaplan–Meier survival curve and log-rank test were used to analyse implant survivorship following DAIR.

Results

Of the sixty patients (40 knees, 20 hips) who underwent DAIR, eighteen (13 knees, 5 hips) required revision arthroplasty within 2 years accounting for a success rate of 70%. Predictive factors for revision were American Society of Anaesthesiologist (ASA) score of greater than 2 (p = 0.021), BMI > 35 (p = 0.046), C Reactive protein (CRP) > 200 mg/L (p = 0.007) and Staphylococcus aureus growth (p = 0.012). The five-year survival rate for DAIR was 70%, which remained constant after two years from DAIR.

Conclusion

Success rate of DAIR in PJI was 70% which was comparable to similar studies in the literature. ASA > 2, BMI > 35, CRP > 200 and staphylococcus aureus growth were predictors for DAIR failure. Implant survival rate and duration were better following DAIR in early-onset PJI.

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Authors and Affiliations

  1. Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, Glasgow, Scotland, UK

    Sriganesh Walkay, David Tran Wallace, Vijay Shankar Coimbatore Balasubramaniam, Rohit Maheshwari, Manish Changulani & Martin Sarungi

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  1. Sriganesh Walkay
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  2. David Tran Wallace
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  3. Vijay Shankar Coimbatore Balasubramaniam
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Correspondence to Vijay Shankar Coimbatore Balasubramaniam.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.

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Walkay, S., Wallace, D.T., Balasubramaniam, V.S.C. et al. Outcomes of Debridement, Antibiotics and Implant Retention (DAIR) for Periprosthetic Joint Infection in a High-Volume Arthroplasty Centre. JOIO 56, 1449–1456 (2022). https://doi.org/10.1007/s43465-022-00655-y

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