Abstract
As adsorbents directly interact with the biological fluid, they can induce normal physiological mechanisms for repairing body functionality. As a result, biopolymers are widely used as natural and biocompatible alternatives to synthetic adsorbents for establishing body homeostasis in medical treatment. In this regard, relevant properties of carbohydrate-based bioactive adsorbents can be tailored to contribute to the design of safer coatings surfaces for implant devices. This review explores the most common polysaccharide-based polymers applicable in blood-contacting devices for treating degenerative diseases, wound healing, and developing anti-thrombogenic surfaces. Furthermore, challenges and limitations of blood-contacting devices that must still be tackled and strategies to enhance their hemocompatibility are described to encourage their prospective use.
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The authors would like to thank the Coordination for improving Higher Education Personnel (CAPES), National Council of Technological and Scientific Development (CNPq) for funding this research. This research was also supported by the following projects: CNPq (421039/2016-7) and PROCAD/CAPES (88881.068439/2014-01).
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de Brito Soares, A.L., Maia, M.T., Gomes, S.D.L. et al. Polysaccharide-based bioactive adsorbents for blood-contacting implant devices. Braz. J. Chem. Eng. 39, 1033–1046 (2022). https://doi.org/10.1007/s43153-022-00253-3
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DOI: https://doi.org/10.1007/s43153-022-00253-3