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Combination of Dydrogesterone and Antibiotic Versus Antibiotic Alone for Chronic Endometritis: a Randomized Controlled Trial Study

  • Abnormal Uterine Bleeding: Clinical Trials
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Abstract

To evaluate the impact of dydrogesterone in the treatment of chronic endometritis with antibiotic treatment in premenopausal women. A total of 188 chronic endometritis patients diagnosed by syndecan-1 (CD138) expression were enrolled in this randomized controlled trial study. Dydrogesterone and doxycycline were given in the treatment group, while single antibiotic was given in the control group. CD138, estrogen receptor, and progesterone receptor expression in samples of the endometrium was analyzed by immunohistochemistry. Comparison of chronic endometritis cure rate between groups was performed based on conversion of CD138 expression from positive to negative. The 188 cases included in the statistical analysis consisted of 93 cases in the treatment group and 95 cases in the control group. The cure rates of chronic endometritis in the dydrogesterone and antibiotic combination group and the single antibiotic group were 86.0% (80/93) and 72.6% (69/95), respectively, with an overall cure rate of 79.3% (149/188). The dydrogesterone and antibiotic combination group showed better effects regarding the cure rate of chronic endometritis (P<.05). Multivariate analysis showed that the cure rate of chronic endometritis was not affected by age, clinical diagnosis, hysteroscopic resection, estrogen receptor status, or progesterone receptor status (all P>.05). Addition of dydrogesterone was effective for the treatment of chronic endometritis with antibiotic treatment in premenopausal women. The study was retrospectively registered to Chinese Clinical Trial Registry (ChiCTR2000040227) in November 2020.

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Data Availability

The datasets generated and analyzed during the present study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors thank Wei Xu and Yubo Zhang for processing statistical data.

Funding

Supported by the Sichuan Science and Technology Program (2018SZ0264) and North Sichuan Medical College Program (CBY17-A-YB13).

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Author notes

  1. Dacheng Qu and Maomei Yang contributed equally to this work.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Affiliated Hospital of North Sichuan Medical College, No 63, Wenhua Road, Nanchong, Sichuan province, China

    Dacheng Qu, Xin Yu, Qiao Jing, Yamei Yang & Honggui Zhou

  2. Department of Obstetrics and Gynecology, Chengdu Second People’s Hospital, Chengdu, China

    Maomei Yang

  3. Department of Obstetrics and Gynecology, Nanbu County People’s Hospital, Nanbu, China

    Lina Tong

Authors
  1. Dacheng Qu
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  4. Xin Yu
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  5. Qiao Jing
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Contributions

Dacheng Qu and Honggui Zhou designed most of the investigation, data analysis, and wrote the manuscript; Dacheng Qu, Maomei Yang and Lina Tong performed most of the investigation; Yamei Yang and Xin Yu contributed to data curation; Dacheng Qu and Qiao Jing contributed to interpretation of the data and analyses. All of the authors have read and approved the manuscript.

Corresponding author

Correspondence to Honggui Zhou.

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Ethical Approval

This study was conducted after the authorization of the Ethical Committee of Affiliated Hospital of North Sichuan Medical College (No. 2019ER (R) 017).

Consent to Participate

All patients included in the study had signed the approved informed consent to participate.

Consent for Publication

All patients included in the study had signed the approved informed consent to allow publication of anonymous data.

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The authors declare no competing interests.

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Qu, D., Yang, M., Tong, L. et al. Combination of Dydrogesterone and Antibiotic Versus Antibiotic Alone for Chronic Endometritis: a Randomized Controlled Trial Study. Reprod. Sci. 28, 3073–3080 (2021). https://doi.org/10.1007/s43032-021-00583-6

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  • DOI: https://doi.org/10.1007/s43032-021-00583-6

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