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Lipopeptides from Bacillus: unveiling biotechnological prospects—sources, properties, and diverse applications

  • Biotechnology and Industrial Microbiology - Review
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Abstract

Bacillus sp. has proven to be a goldmine of diverse bioactive lipopeptides, finding wide-range of industrial applications. This review highlights the importance of three major families of lipopeptides (iturin, fengycin, and surfactin) produced by Bacillus sp. and their diverse activities against plant pathogens. This review also emphasizes the role of non-ribosomal peptide synthetases (NRPS) as significant enzymes responsible for synthesizing these lipopeptides, contributing to their peptide diversity. Literature showed that these lipopeptides exhibit potent antifungal activity against various plant pathogens and highlight their specific mechanisms, such as siderophore activity, pore-forming properties, biofilm inhibition, and dislodging activity. The novelty of this review comes from its comprehensive coverage of Bacillus sp. lipopeptides, their production, classification, mechanisms of action, and potential applications in plant protection. It also emphasizes the importance of ongoing research for developing new and enhanced antimicrobial agents. Furthermore, this review article highlights the need for future research to improve the production efficiency of these lipopeptides for commercial applications. It recognizes the potential for these lipopeptides to expand the field of biological pest management for both existing and emerging plant diseases.

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Acknowledgements

AK gratefully acknowledges DST-SERB for financial support obtained through the project grant of (CRG/2021/003696), New Delhi, Govt of India.

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  1. Diksha Saiyam, Anamika Dubey and Muneer Ahmad Malla contributed equally.

Authors and Affiliations

  1. Metagenomics and Secretomics Research Laboratory, Department of Botany, Dr. Harisingh Gour University (A Central University), Sagar, 470003, MP, India

    Diksha Saiyam, Anamika Dubey, Muneer Ahmad Malla & Ashwani Kumar

  2. Department of Zoology, Dr. Harisingh Gour University (A Central University), Sagar, 470003, MP, India

    Muneer Ahmad Malla

  3. Metagenomics and Secretomics Research Laboratory, Department of Botany, University of Allahabad (A Central University), Prayagraj, 211002, UP, India

    Ashwani Kumar

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DS and AD prepared the draft of the manuscript. The manuscript was overseen and revised by MAM and AK.

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Saiyam, D., Dubey, A., Malla, M.A. et al. Lipopeptides from Bacillus: unveiling biotechnological prospects—sources, properties, and diverse applications. Braz J Microbiol 55, 281–295 (2024). https://doi.org/10.1007/s42770-023-01228-3

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