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Temporal analysis of bovine pestivirus diversity in Brazil

  • Veterinary Microbiology - Research Paper
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A Correction to this article was published on 12 April 2022

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Abstract

In this study, phylogenetic and evolutionary analyses of cattle pestiviruses (BVDV-1, 2 and HoBiPeV) originating in Brazil were used to investigate the temporal diversification of subgenotypes in the country. Inferred dated phylogeny and time of the most recent common ancestor (tMRCA) demonstrated that some BVDV subgenotypes (1a, 1b, 1d, 1e, and 2b) and HoBi-like sequences clustered according to the region in which they were collected and that the diversification of subgenotypes appears to have occurred around the introduction of first Bos taurus and then Bos indicus, followed by expansion to form the adapted Brazilian breeds. The present results help to elucidate the temporal facts that led to diversification of ruminant pestiviruses in cattle in Brazil.

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References

  1. Fourichon C, Beaudeau F, Bareille N, Seegers H (2005) Quantification of economic losses consecutive to infection of a dairy herd with bovine viral diarrhoea virus. Prev Vet Med 72(1–2):177–181

    Article  Google Scholar 

  2. Richter V, Lebl K, Baumgartner W, Obritzhauser W, Käsbohrer A, Pinior B (2017) A systematic worldwide review of the direct monetary losses in cattle due to bovine viral diarrhoea virus infection. Vet J 220:80–87

    Article  Google Scholar 

  3. Rodning SP, Givens MD, Marley MSD, Zhang Y, Riddell KP, Galik PK et al (2012) Reproductive and economic impact following controlled introduction of cattle persistently infected with bovine viral diarrhea virus into a naive group of heifers. Theriogenology 78(7):1508–1516

    Article  CAS  Google Scholar 

  4. USDA. Livestock and poultry: world markets and trade (2021). https://apps.fas.usda.gov/psdonline/circulars/livestock_poultry.pdf>.

  5. Ridpath JF, Bolin SR, Dubovi EJ (1994) Segregation of bovine viral diarrhea virus into genotypes. Virology 205(1):66–74

    Article  CAS  Google Scholar 

  6. Pellerin C, Van Den Hurk J, Lecomte J, Tijssen P (1994) Identification of a new group of bovine viral diarrhea virus strains associated with severe outbreaks and high mortalities. Virology 203(2):260–268

    Article  CAS  Google Scholar 

  7. Van Campen H, Vorpahl P, Huzurbazar S, Edwards J, Cavender J (2000) A case report: evidence for type 2 bovine viral diarrhea virus (BVDV)-associated disease in beef herds vaccinated with a modified-live type 1 BVDV vaccine. J Vet Diagn Invest 12(3):263–265

    Article  Google Scholar 

  8. , Ridpath, J. F., Bolin, S. R., & Dubovi, E. J. (1994). Segregation of bovine viral diarrhea virus into genotypes. Virology, 205(1), 66–74.10.

  9. Schirrmeier H, Strebelow G, Depner K, Hoffmann B, Beer M (2004) Genetic and antigenic characterization of an atypical pestivirus isolate, a putative member of a novel pestivirus species. J Gen Virol 85:3647–3652

    Article  CAS  Google Scholar 

  10. Smith, D. B.; Meyers, G.; Bukh, J.; Gould, E. A.; Monath, T.; Muerhoff, A. S.; Pletnev, A.; Rico-Hesse, R.; Stapleton, J. T.; Simmonds, P. & Becher, P. Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae. The Journal of General Virology, v. 98 2106–2112, 2107.

  11. Yeşilbağ K, Alpay G, Becher P (2017) Variability and global distribution of subgenotypes of bovine viral diarrhea virus. Viruses 9(6):128

    Article  Google Scholar 

  12. Vilcek S, Paton DJ, Durkovic B, Strojny L, Ibata G, Moussa A, Loitsch A, Rossmanith W, Vega S, Scicluna MT, Paifi V (2001) Bovine viral diarrhoea virus genotype 1 can be separated into atleast eleven genetic groups. Adv Virol 146:99–115

    CAS  Google Scholar 

  13. Silveira S, Weber MN, Mósena ACS, Da Silva MS, Streck AF, Pescador CA et al (2017) Genetic diversity of Brazilian bovine pestiviruses detected between 1995 and 2014. Transbound Emerg Dis 64(2):613–623

    Article  CAS  Google Scholar 

  14. Kalaiyarasu, S., Mishra, N., Jayalakshmi, K., Selvaraj, P., Sudhakar, S. B., Jhade, S. K., et al. (2021). Molecular characterization of recent HoBi-like pestivirus isolates from cattle showing mucosal disease-like signs in India reveals emergence of a novel genetic lineage. Transbound. emerg. dis.(Internet)

  15. Weber MN, Silveira S, Machado G, Groff FHS, Mósena ACS, Budaszewski RF et al (2014) High frequency of bovine viral diarrhea virus type 2 in Southern Brazil. Virus Res 191:117–124

    Article  CAS  Google Scholar 

  16. Silveira S, Baumbach LF, Weber MN, Mósena ACS, Da Silva MS, Cibulski SP et al (2018) HoBi-like is the most prevalent ruminant pestivirus in Northeastern Brazil. Transbound Emerg Dis 65(1):e113–e120

    Article  CAS  Google Scholar 

  17. McManus C, Barcellos JOJ, Formenton BK, Hermuche PM, Carvalho OAD Jr, Guimarães R, Neto JB (2016) Dynamics of cattle production in Brazil. PloS one 11(1):e0147138

    Article  Google Scholar 

  18. Ferraz JBS, de Felício PE (2010) Production systems–an example from Brazil. Meat Sci 84(2):238–243

    Article  Google Scholar 

  19. Chao L (1997) Evolution of sex and the molecular clock in RNA viruses. Gene 205:301–308

    Article  CAS  Google Scholar 

  20. Bachofen C, Stalder H, Braun U et al (2008) Co-existence of genetically and antigenically diverse bovine viral diarrhoea viruses in an endemic situation. Vet Microbiol 131:93–102

    Article  CAS  Google Scholar 

  21. Weber MN, Wolf JM, da Silva MS, Mosena ACS, Budaszewski RF, Lunge VR, Canal CW (2021) Insights into the origin and diversification of bovine viral diarrhea virus 1 subtypes. Adv Virol 166(2):607–611

    CAS  Google Scholar 

  22. Silveira S, Cibulski SP, Junqueira DM, Mósena ACS, Weber MN, Mayer FQ, Canal CW (2020) Phylogenetic and evolutionary analysis of HoBi-like pestivirus: insights into origin and dispersal. Transbound Emerg Dis 67(5):1909–1917

    Google Scholar 

  23. Liu L, Xia H, Wahlberg N, Belák S, Phylogeny Baule C (2009) classification and evolutionary insights into pestiviruses. Virology 385(2):351–7

    Article  CAS  Google Scholar 

  24. Luzzago C, Ebranati E, Sassera D, Presti AL, Lauzi S, Gabanelli E, ... and Zehender G (2012) Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy. Infection, Genetics and Evolution, 12(2), 324-331

  25. Wang L, Wu X, Wang C, Song C, Bao J, Du J (2020) Origin and transmission of bovine viral diarrhea virus type 1 in China revealed by phylodynamic analysis. Res Vet Sci 128:162–169

    Article  CAS  Google Scholar 

  26. Maya L, Macías-Rioseco M, Silveira C, Giannitti F, Castells M, Salvo M et al (2020) An extensive field study reveals the circulation of new genetic variants of subtype 1a of bovine viral diarrhea virus in Uruguay. Adv Virol 165(1):145–156

    CAS  Google Scholar 

  27. Chernick A, Godson DL, van der Meer F (2014) Metadata beyond the sequence enables the phylodynamic inference of bovine viral diarrhea virus type 1a isolates from Western Canada. Infect Genet Evol 28:367–374

    Article  Google Scholar 

  28. Vilcek S, Herring AJ, Herring JA, Nettleton PF, Lowing JP, Paton DJ (1994) Pestivirus isolated from pig, cattle and sheep can be allocated into at least three genogroups using PCR and restriction endonuclease analysis. Arch Virol 136:309–323

    Article  CAS  Google Scholar 

  29. Guindon S, Gascuel O (2003) A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52(5):696–704

    Article  Google Scholar 

  30. Bauermann FV, Flores EF, Ridpath JF (2012) Antigenic relationships between bovine viral diarrhea virus 1 and 2 and HoBi virus: possible impacts on diagnosis andcontrol. J Vet Diagn Invest 24(2):253–261

    Article  Google Scholar 

  31. Flores EF, Cargnelutti JF, Monteiro FL, Bauermann FV, Ridpath JF, Weiblen R (2018) A genetic profile of bovine pestiviruses circulating in Brazil (1998–2018). Anim Health Res Rev 19(2):134–141

    Article  CAS  Google Scholar 

  32. Monteiro FL, Martins B, Cargnelutti JF, Noll JG, Weiblen R, Flores EF (2019) Genetic identification of pestiviruses from beef cattle in Southern Brazil. Braz J Microbiol 50(2):557–563

    Article  CAS  Google Scholar 

  33. Cerutti F, Luzzago C, Lauzi S, Ebranati E, Caruso C, Masoero L et al (2016) Phylogeography, phylodynamics and transmission chains of bovine viral diarrhea virus subtype 1f in Northern Italy. Infect Genet Evol 45:262–267

    Article  Google Scholar 

  34. Aiewsakun P, Katzourakis A (2016) Time-dependent rate phenomenon in viruses. J Virol 90:7184–7195

    Article  CAS  Google Scholar 

  35. Hamers C, Dehan P, Couvreur B, Letellier C, Kerkhofs P, Pastoret PP (2001) Diversity among bovine pestiviruses. Vet J 161(2):112–122

    Article  CAS  Google Scholar 

  36. Brown RJ, Juttla VS, Tarr AW, Finnis R, Irving WL, Hemsley S et al (2005) Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection. J Gen Virol 86(7):1931–1942

    Article  CAS  Google Scholar 

  37. Santana ML Jr, Pereira RJ, Bignardi AB, El Faro L, Tonhati H, Albuquerque LG (2014) History, structure, and genetic diversity of Brazilian Gir cattle. Livest Sci 163:26–33

    Article  Google Scholar 

  38. Martínez AM, Gama LT, Cañón J, Ginja C, Delgado JV, Dunner S et al (2012) Genetic footprints of Iberian cattle in America 500 years after the arrival of Columbus. PLoS One 7(11):e49066

    Article  Google Scholar 

  39. Ajmone-Marsan P, Garcia JF, Lenstra JA (2010) On the origin of cattle: how aurochs became cattle and colonized the world. Evol Anthropol: Issues, News, Rev 19(4):148–157

    Article  Google Scholar 

  40. Bianchi MV, Konradt G, De Souza SO, Bassuino DM, Silveira S, Mósena ACS et al (2017) Natural outbreak of BVDV-1d–induced mucosal disease lacking intestinal lesions. Vet Pathol 54(2):242–248

    Article  CAS  Google Scholar 

  41. Reardon F, Graham DA, Clegg TA, Tratalos JA, O’Sullivan P, More SJ (2018) Quantifying the role of Trojan dams in the between-herd spread of bovine viral diarrhoea virus (BVDv) in Ireland. Prev Vet Med 152:65–73

    Article  Google Scholar 

Download references

Funding

Funding was provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)—Finance Code 001, Fundação de Amparo à Pesquisa do Rio Grande do Sul [FAPERGS), Pró-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Sul (Propesq/UFRGS).

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Authors and Affiliations

  1. Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil

    Ana Cristina Sbaraini Mosena, Willian Pinto Paim, Letícia Ferreira Baumbach, Juliana do Canto Olegário, Renata da Fontoura Budaszewski & Cláudio Wageck Canal

  2. Laboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil

    Ana Cristina Sbaraini Mosena, Mariana Soares da Silva & Matheus Nunes Weber

  3. Laboratório de Diagnóstico Molecular, Universidade Luterana Do Brasil [ULBRA), Canoas, RS, Brazil

    Jonas Michel Wolf

  4. Laboratório de Imunodiagnóstico, Faculdade de Medicina Veterinária, Universidade Do Oeste de Santa Catarina (UNOESC), Xanxerê, SC, Brazil

    Simone Silveira

Authors
  1. Ana Cristina Sbaraini Mosena
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  2. Jonas Michel Wolf
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  3. Willian Pinto Paim
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  4. Letícia Ferreira Baumbach
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  5. Mariana Soares da Silva
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  6. Simone Silveira
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  7. Juliana do Canto Olegário
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  8. Renata da Fontoura Budaszewski
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  9. Matheus Nunes Weber
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  10. Cláudio Wageck Canal
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Contributions

All authors contributed to the study conception and design. Conceptualization was performed by Ana Cristina Sbaraini Mosena and Matheus Nunes Weber, and investigation was performed by Ana Cristina Sbaraini Mosena, Willian Pinto Paim, Letícia Ferreira Baumbach, Mariana Soares da Silva, Simone Silveira, Juliana do Canto Olegário and Renata da Fontoura Budaszewski. The molecular clock formal analysis was performed by Jonas Michel Wolf. The first draft of the manuscript was written by Ana Cristina Sbaraini Mosena and all authors commented on previous versions of the manuscript. Review & editing of the manuscript was made by Matheus Nunes Weber and Cláudio Wageck Canal. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ana Cristina Sbaraini Mosena.

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Mosena, A.C.S., Wolf, J.M., Paim, W.P. et al. Temporal analysis of bovine pestivirus diversity in Brazil. Braz J Microbiol 53, 1675–1682 (2022). https://doi.org/10.1007/s42770-022-00735-z

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  • DOI: https://doi.org/10.1007/s42770-022-00735-z

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