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Post-translational modifications of nuclear sirtuins

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Abstract

Silent information regulator proteins (SIRT), or sirtuins, are evolutionarily conserved NAD+-dependent deacetylases and ADP-mono-ribosyltransferases. In mammalian, seven sirtuins have been identified, namely SIRT1–7, with different subcellular localization. Nuclear sirtuins, including SIRT1, SIRT6 and SIRT7, localize predominantly in the nucleus and are implicated in many vital biological processes, including stress response, transcription, genome maintenance, tumorigenesis and aging. Dysregulation of nuclear sirtuins is associated with the development of many diseases, including cancer and metabolic disorders. Therefore, the activities of nuclear sirtuins must be properly regulated. In this review, we summarize the current knowledge on the post-translational modifications of nuclear sirtuins and discuss how these modifications modulate their functions.

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  1. School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

    Kaiqiang Zhao & Zhongjun Zhou

  2. Shenzhen Institute of Research and Innovation, The University of Hong Kong, Pok Fu Lam, Hong Kong

    Kaiqiang Zhao & Zhongjun Zhou

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Zhao, K., Zhou, Z. Post-translational modifications of nuclear sirtuins. GENOME INSTAB. DIS. 1, 34–45 (2020). https://doi.org/10.1007/s42764-019-00001-x

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