Abstract
Endophytes are the microorganisms (bacteria or fungi) which live inside the plant without causing any kind of unhealthy symptoms to the host. They are endosymbiont in nature and assist the plant in promoting their growth and development. Similar to bacteria, endophytes also own the quorum sensing (QS) system for communication with each other and use it to organize their gene expression among local populations. Particularly, this paradox is a density-dependent where these microbes use the cascade to control the genes that endorse attack, resistance, and multiplication of their community. With the continuing manifestation of resistance mechanisms against antibiotics shown by pathogens, there is a contemporary requirement for the development of alternative therapeutic approach. An anti-virulence and antimicrobial mechanism by which QS is obstructed, has been providing a way for the modification of pathogenic processes. Recognition and classification of target autoinducers along with their signaling pathway can be helpful for the researchers to combat the harmful and lethal effect of the pathogenic microorganisms with the help of endophytes secreting bio-active substances like malabaricone and rosmarinic acid. Therefore, the current review focuses on QS, quorum quenching and their respective signaling molecules of endophytes which endorse as the medicinal substitute of synthetic pharmaceutical drugs and protection of plants from phytopathogems.
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References
Abisado RG, Benomar S, Klaus JR, Dandekar AA, Chandler JR (2018) Bacterial quorum sensing and microbial community interactions. MBio 9:e02331-17
Ahlgren NA, Harwood CS, Schaefer AL, Giraud E, Greenberg EP (2011) Aryl-homoserine lactone quorum sensing in stem-nodulating photosynthetic bradyrhizobia. Proc Natl Acad Sci USA 108:7183–7188
Anetzberger C, Reiger M, Fekete A, Schell U, Stambaugh N et al (2012) Autoinducers act as biological timers in Vibrio harveyi. PLoS ONE 7:10
Ball AS, Chaparian RR, Kessel JCV (2017) Quorum sensing gene regulation by LuxR/HapR master regulators in vibrios. J Bacteriol 199(19):1–31
Banerjee G, Ray AK (2017) Quorum-sensing network-associated gene regulation in Gram-positive bacteria. Acta Microbiol Imm H 64(4):439–453
Barnard AML, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GPC (2007) Virulence and secondary metabolite production in plant soft-rotting bacteria. Phil Trans R Soc B 362:1165–1183
Bassler BL, Losick R (2006) Bacterially speaking. Cell 125:237–246
Butler MT, Wang Q, Harshey RM (2010) Cell density and mobility protect swarming bacteria against antibiotics. Proc Natl Acad Sci USA 107(8):3776–3781
Chen F, Gao Y, Chen X, Yu Z, Li X (2013) Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection. Int J Mol Sci 14(9):17477–17500
Chernin L (2011) Quorum-sensing signals as mediators of PGPR’s beneficial traits. In: Maheshwari DK (ed) Bacteria in agrobiology: plant nutrients management. Springer, Berlin/Heidelberg, pp 209–236
Chong YM, Yin WF, Ho CY, Mustafa MR et al (2011) Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity. J Nat Prod 74:2261–2264
Chu Y-Y, Nega M, Wolfle M, Plener L, Grond S et al (2013) A new class of quorum quenching molecules from Staphylococcus Species affects communication and growth of Gram-negative bacteria. PLoS Pathog 9(9):e1003654
Deng Y, Wu J, Eberl L, Zhang LH (2010) Structural and functional characterization of diffusible signal factor family quorum-sensing signals produced by members of the Burkholderia cepacia complex. Appl Environ Microbiol 76:4675–4683
Deng Y et al (2012) Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with the regulation of virulence through cyclic dimeric Guanosine Monophosphate turnover. Proc Natl Acad Sci USA 109:15479–15484
Deng Y, Lim A, Lee J, Chen S, An S, Dong YH, Zhang LH (2014) Diffusible signal factor (DSF) quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens. BMC Microbiol 14:51
Dixit S, Dubey RC, Maheshwari DK, Seth PK, Bajpai VK (2017) Roles of quorum sensing molecules from Rhizobium etli RT1 in bacterial motility and biofilm formation. Braz J Microbiol 48:815–821
Dong W, Zhu J, Guo X et al (2018) Characterization of AiiK, an AHL lactonase, from Kurthia huakui LAM0618T and its application in quorum quenching on Pseudomonas aeruginosa PAO1. Sci Rep 8(1):6013
Fahmi T, Port GC, Cho KH (2017) c-di-AMP: an essential molecule in the signaling pathways that regulate the viability and virulence of Gram-positive bacteria. Genes 8(8):197
Federle MJ, Bassler BL (2003) Interspecies communication in bacteria. J Clin Invest 112:1291–1299
Feng L et al (2015) A QRR noncoding RNA deploys four different regulatory mechanisms to optimize quorum-sensing dynamics. Cell 160:228–240
Flavier AB, Clough SJ, Schell MA, Denny TP (1997) Identification of 3-hydroxypalmitic acid methyl ester as a novel autoregulator controlling virulence in Ralstonia solanacearum. Mol Microbiol 26:251–259
Galperin MY, Nikolskaya AN, Koonin EV (2001) Novel domains of the prokaryotic two-component signal transduction systems. FEMS Microbiol Lett 203:11–21
Genin S, Denny TP (2012) Pathogenomics of the Ralstonia solanacearum species complex. Annu Rev Phytopathol 50:67–89
Goryachev AB (2009) Design principles of the bacterial quorum sensing gene networks. Wiley Interdiscip Rev Syst Biol Med 1:45–60
Ha NT, Minh TQ, Hoi PX, Nguyen et al (2018) Biological control of potato tuber soft rot using N-acyl-l-homoserine lactone-degrading endophytic bacteria. Curr Sci 115(10):1921–1927
Hawver LA, Jung SA, Ng WL (2016) Specificity and complexity in bacterial quorum-sensing systems. FEMS Microbiol Rev 40(5):738–752
Hong KW, Koh CL, Sam CK, Yin WF, Chan KG (2012) Quorum quenching revisited-from signal decays to signaling confusion. Sensors 12:4661–4696
Jakobsen TH, Van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PO, Nielsen KF, Eberl L, Larsen TO, Tanner Hoiby N, Bjarnsholt T, Givskov M (2012) Ajoene, a sulfur-rich molecule from garlic, inhibits gene controlled by quorum sensing. Antimicrob Agents Chemother 56:2314–2325
Jaramillo-Colorado B, Olivero- Verbel J, Stashenko EE, Wagner-Dobler I, Kunze B (2012) Anti-quorum sensing activity of essential oils from Colombian plants. Nat Prod Res 26(12):1075–1086
Keshavan ND, Chowdhary PK, Haines DC, Gonzalez JE (2005) L-Canavanine made by Medicago sativa interferes with quorum sensing in Sinorhizobium meliloti. J Bacteriol 187:8427–8436
Koh CL, Sam CK, Yin WF, Tan LY, Krishnan T, Chong YM, Chan KG (2013) Plant-derived natural products as sources of anti- compounds. Sensors 13:6217–6228
Konai MM, Dhanda G, Haldar J (2018) Talking through chemical languages: quorum sensing and bacterial communication. In: Kalia VC (ed) Quorum sensing and its biotechnological applications, 1st edn. Springer, Singapore, pp 17–42
Kusari P, Kusari S, Spiteller M, Kayser O (2015) Implications of endophyte-plant crosstalk in light of quorum responses for plant biotechnology. Appl Microbiol Biotechnol 99:5383–5390
Kyung KH, Lee YC (2001) Antimicrobial activities of sulfur compounds derived from S-alk(en)yl-l-cysteine sulfoxides in Allium and Brassica. Food Rev Int 17:183–198
Lade H, Paul D, Kweon JH (2014) N-acyl homoserine lactone-mediated quorum sensing with special reference to use of quorum quenching bacteria in membrane biofouling control. Biomed Res Int 2014:1–25
LaSarre B, Federle MJ (2013) Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77(1):73–111
Lenz DH et al (2004) The small RNA chaperone Hfq and multiple small RNAs control in Vibrio harveyi and Vibrio cholerae. Cell 118:69–82
Lilley BN, Bassler BL (2000) Regulation of quorum sensing in Vibrio harveyi by LuxO and σ54. Mol Microbiol 36:940–954
Liu X, Jia J, Popat R, Ortori CA, Li J, Diggle SP, Gao K, Camara M (2011) Characterisation of two systems in the endophytic Serratia plymuthica strain G3: differential control of motility and biofilm formation according to lifestyle. BMC Microbiol 11:26
Mookherjee A, Singh S, Maiti MK (2017) Quorum sensing inhibitors: can endophytes be prospective sources? Arch Microbiol 200:1–16
Ng WL, Bassler BL (2009) Bacterial quorum-sensing network architectures. Annu Rev Genet 43:197–222
Papenfort K, Bassler BL (2016) Quorum sensing signal–response systems in Gram-negative bacteria. Nat Rev Microbiol 14:576–588
Papenfort K, Vogel J (2010) Regulatory RNA in bacterial pathogens. Cell Host Microbe 8:116–127
Pereira CS, de Regt AK, Brito PH, Miller ST, Xavier KB (2009) Identification of functional LsrB-like autoinducer-2 receptors. J Bacteriol 191:6975–6987
Pesavento C, Hengge R (2009) Bacterial nucleotide-based second messengers. Curr Opin Microbiol 12:170–176
Rajesh PS, Ravishankar RV (2014) Quorum quenching activity in the cell-free lysate of endophytic bacteria isolated from Pterocarpus santalinus Linn., and its effect on quorum sensing regulated biofilm in Pseudomonas aeruginosa PAO1. Microbiol Res 169(7–8):561–569
Rasmussen TB, Bjarnsholt T, Skindersoe ME et al (2005) Screening for quorum sensing inhibitors (QSI) by use of the novel genetic system, the QSI selector. J Bacteriol 187:1799–1814
Reen FJ, Gutierrez-Barranquero JA, Parages ML, Gara F O (2018) Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition. Appl Microbiol Biotechnol 102(5):2063–2073
Remy B, Mion S, Plener L, Elias M, Chabriere E, Daude D (2018) Interference in bacterial quorum sensing: a biopharmaceutical perspective. Front Pharmacol 9:203
Rudrappa T, Bais HP (2008) Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal. J Agric Food Chem 56:1955–1962
Rutherford ST, Bassler BL (2012) Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med 2(11):a012427
Schaefer AL, Greenberg EP, Oliver CM, Oda Y et al (2008) A new class of homoserine lactone quorum-sensing signals. Nature 454:595–599
Schuster M, Sexton DJ, Diggle SP, Greenberg EP (2013) Acyl-homoserine lactone quorum sensing: from evolution to application. Annu Rev Microbiol 67:43–63
Shin D, Frane ND, Brecht RM, Keeler J, Nagarajan R (2015) A comparative analysis of acyl-homoserine lactone synthase assays. ChemBioChem 16(18):2651–2659
Singh HB (2014) Management of plant pathogens with microorganisms. Proc Indian Natl Sci Acad 80(2):443–454
Singh S, Singh SK, Chowdhury I, Singh R (2017) Understanding the mechanism of bacterial biofilms resistance to antimicrobial agents. Open microbiol J 11:53–62
Sivasothy Y, Krishnan T, Chan KG et al (2016) Quorum sensing inhibitory activity of giganteone a from Myristica cinnamomea king against Escherichia coli biosensors. Molecules 21(3):391
Swem LR, Swem DL, Wingreen NS, Bassler BL (2008) Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi. Cell 134:461–473
Swem LR et al (2009) A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity. Mol Cell 35:143–153
Teplitski M, Robinson JB, Baure WD (2000) Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria. Mol Plant Microbe Interact 13(6):637–648
Vadakkan K, Choudhury AA, Gunasekaran R, Hemapriya J, Vijayanand S (2018) Quorum sensing intervened bacterial signaling: pursuit of its cognizance and repression. JGEB 16:239–252
Vasavi HS, Arun AB, Rekha PD (2013) Inhibition of quorum sensing in Chromobacterium violaceum by Syzygium cumini L. and Pimenta dioca L. Asian Pac J. Trop Biomed 3(12):954–959
Vasavi HS, Arun AB, Rekha PD (2014) Anti-quorum sensing activity of Psidium guajava L. flavonoids against Chromobacterium violaceum and Pseudomonas aeruginosa PAO1. Microbiol Immunol 58(5):286–293
Walker TS, Bais HP, Deziel E, Schweizer HP, Rahme LG, Fall R, Vivanco JM (2004) Pseudomonas aeruginosa plant root interaction, pathogenicity, biofilm formation, and root exudation. Plant Physiol 134(1):320–331
Zapata LS, Tabarez MR, Álvarez JC, Escobar VV (2017) Reviewing microbial behaviors in ecosystems leading to a natural quorum quenching occurrence. Braz Arch Biol Technol 60:e17160295
Zhang W, Li C (2016) Exploiting quorum sensing interfering strategies in Gram-negative bacteria for the enhancement of environmental applications. Front Microbiol 6:1535
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Funding has been received form Science and Engineering Research Board with Grand No. (No.SB/EMEQ-088/2014,Dt. 28/01/2016).
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Venkatesh Kumar, R., Singh, R.P. & Mishra, P. Endophytes as emphatic communication barriers of quorum sensing in Gram-positive and Gram-negative bacteria—a review. Environmental Sustainability 2, 455–468 (2019). https://doi.org/10.1007/s42398-019-00079-9
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DOI: https://doi.org/10.1007/s42398-019-00079-9