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Construction of Antibacterial and Bioactive Surface for Titanium Implant

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Abstract

Titanium (Ti) and its alloy are extensively used as hard tissue implant materials in the medical field due to their good mechanical and biological properties. However, implant-associated bacterial infection and delayed osseointegration of an implant to its surrounding bone tissue are still huge challenges to clinicians and material scientists in orthopedic and dental surgery. Therefore, a novel method to construct the antibacterial and bioactive surface for titanium implant was proposed in this study. Briefly, micro/nanostructure was fabricated on the surface of titanium by sandblasting and chemical etching, and silver nanoparticles were then immobilized on the surface by polydopamine (Ag–Ti). The treated sample showed the enhanced roughness, hydrophilicity, and corrosion resistance. And silver ions were released from the treated samples. Moreover, it was observed that the Ag–Ti sample surface covered many calcium phosphate compounds after immersed in simulated body fluid for 7 days. Furthermore, the results of biological tests demonstrated that the treated sample possessed a good antibacterial activity and biocompatibility. This study may provide a new insight for constructing of the antibacterial and bioactive surface for titanium implant to satisfy clinical requirements.

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Acknowledgements

This study was funded by National Natural Science Foundation of China (51575320), Taishan Scholar Foundation (TS20130922).

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Authors and Affiliations

  1. Key Laboratory of High Efficiency and Clean Manufacturing, School of Mechanical Engineering, Shandong University, Jinan, 250061, China

    Yi Wan, Guisen Wang, Bing Ren, Zhanqiang Liu & Peiqi Ge

  2. National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan, 250061, China

    Yi Wan, Guisen Wang, Bing Ren, Zhanqiang Liu & Peiqi Ge

  3. Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China

    Guisen Wang

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  1. Yi Wan
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  2. Guisen Wang
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Correspondence to Yi Wan.

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Wan, Y., Wang, G., Ren, B. et al. Construction of Antibacterial and Bioactive Surface for Titanium Implant. Nanomanuf Metrol 1, 252–259 (2018). https://doi.org/10.1007/s41871-018-0028-5

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  • DOI: https://doi.org/10.1007/s41871-018-0028-5

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