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Quality of Sleep Predicts Prefrontal Cognitive Decline in Indian Collegiates

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Abstract

Purpose

To examine the association between sleep quality and pre-frontal cognition, and to assess the predictive ability of sleep quality measures for mild cognitive impairment (MCI) in collegiate population.

Methods

Forty-nine students were enrolled and categorized as with and without MCI based on the results of Montreal Cognitive Assessment (MoCA). Participants were also subjected to neuropsychological tests (PennCNP) and electrophysiological correlate of cognition-P300. Sleep quality was examined using Pittsburgh Sleep Quality Index (PSQI).

Results

Sleep quality, latency, duration, efficiency, sleep disturbance and medications used for sleep demonstrated significant correlation with cognition (p < 0.05*). At an optimal cut-off of ≥ 8 (area under curve 0.77, p < 0.001*, sensitivity 60%, specificity 85.7%), PSQI global score which measures overall sleep quality predicted occurrence of MCI [odds ratio (CI) 1.46 (1.10–1.93); p = 0.008*)] in adolescents after adjusting for various clinical covariates, such as stress, depression, anxiety and general effect.

Conclusion

Measures of sleep, such as quality, latency, duration, efficiency of sleep along with disturbances in sleep and medications used, are associated with measures of pre-frontal cognition functions. Moreover, a global score of ≥ 8 on PSQI may be considered potential predictor in the occurrence of MCI in collegiates.

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Acknowledgements

Authors would like to thank Mohd. Salman, Medical Electrophysiology Technician, Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia for providing us with technical help during the course of study. We would also like to acknowledge Department of Science and Technology (DST), Government of India, for providing us research grant under Cognitive Science Research Initiative (CSRI), Sanction No. DST/CSRI/2017/209.

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Authors and Affiliations

  1. Neurophysiology Lab, Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India

    Anam Aseem & Pooja Bhati

  2. Department of Neurology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India

    Neera Chaudhry

  3. Faculty of Allied Health Sciences, Shree Guru Gobind Singh Tricentenary University, Gurugram, India

    Mohammed Ejaz Hussain

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  1. Anam Aseem
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Correspondence to Anam Aseem.

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Clearance was obtained from the Institutional Ethics Committee (IEC) of Jamia Millia Islamia (A Central University) which follows guidelines prescribed by IEC, which were in accordance with the Declaration of Helsinki, 1964.

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All the participants signed a written informed consent form before the commencement of the present study.

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Aseem, A., Bhati, P., Chaudhry, N. et al. Quality of Sleep Predicts Prefrontal Cognitive Decline in Indian Collegiates. Sleep Vigilance 5, 127–134 (2021). https://doi.org/10.1007/s41782-021-00136-6

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  • DOI: https://doi.org/10.1007/s41782-021-00136-6

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