Skip to main content

Advertisement

SpringerLink
Log in

Polymers in the Co-delivery of siRNA and Anticancer Drugs for the Treatment of Drug-resistant Cancers

  • Review
  • Published:
Topics in Current Chemistry Aims and scope Submit manuscript

Abstract

Recently, co-delivery of siRNA and anticancer drugs has drawn much attention in the treatment of drug-resistant cancers. Drug resistance is exhibited by cancer cells, which limits the efficacy of chemotherapy. When siRNA and anticancer drugs are delivered into cancer cells simultaneously, the siRNA is expected to silence the genes related to drug resistance, decreasing the drug efflux pumps and activating the cell’s apoptosis pathways. In a timeframe following the release of siRNA, the accumulation of the co-delivered anti-cancer drug inside of the cancer cells will increase, resulting in promoted chemotherapeutic effects. Several classes of nanocarriers have been designed based on polymers for co-delivery, including surface-modified polymer nanoparticles (NPs), polymer micelles, dendrimers, polymer nanocapsules, polymer-modified liposomes, and polymer-modified silica and gold NPs. Compared with separate delivery, co-delivery showed significant advantages in the treatment of drug-resistant cancers. This review focuses on polymers in the co-delivery of siRNA and anticancer drugs, and summarizes key advances in the recent several years.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Adapted with permission [63]. Copyright 2015, Elsevier

Fig. 3

Adapted with permission [65]. Copyright 2015, Elsevier

Fig. 4

Adapted with permission [76]. Copyright 2013, Elsevier

Fig. 5

Adapted with permission [86]. Copyright 2016, American Chemical Society

Fig. 6

Adapted with permission [87]. Copyright 2013, Royal Society of Chemistry

Fig. 7

Adapted with permission [88]. Copyright 2015, American Chemical Society

Fig. 8
Fig. 9

Adapted with permission [100]. Copyright 2014, Elsevier

Fig. 10

Adapted with permission [109]. Copyright 2016, Nature Publishing Group

Similar content being viewed by others

Abbreviations

ABC:

ATP-binding cassette

Bcl-2:

B-cell lymphoma 2

BCRP:

Breast cancer resistance protein

CPLA:

Cationic polylactide

CPT:

Camptothecin

CS:

Chitosan

CSC:

Cancer stem cell

CyD:

Cyclodextrin

DDAB:

Dimethyldioctadecyl ammonium bromide

DEA:

Diethyldiamine

DOC:

Docetaxel

DOPE:

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

DOX:

Doxorubicin

DSPE:

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

DTT:

14-Dithiothreitol

EpCAM:

Epithelial cell adhesion molecule

FA:

Folic acid

Fol:

Folate

Gem:

Gemcitabine

HepG2:

Hepatic G2 cells

HIF1 α:

Hypoxia-inducible factor 1α

HNP:

Hybrid nanoparticle

HPG:

Hyperbranched polyglycerol

HZ:

Hydrazone

LDL:

Low-density lipoprotein

LENP:

Lipid/ε-polylysine-coated nanoparticle

LND:

Lonidamine

LNP:

Lipid nanoparticle

MDR:

Multidrug resistance

MNP:

Magnetic nanoparticle

MRP1:

MDR-associated protein 1

N/P:

Nitrogenphosphate

NP:

Nanoparticle

NCP:

Nanoscale coordination polymer

NIR:

Near-infrared

NSC:

N-succinyl chitosan

OCN:

One-component nanomedicine

PAA:

Poly(acrylic acid)

PAMAM:

Poly(amidoamine)

PBLA:

Poly(β-benzyl l-aspartate)

PCB:

Polycarboxybetaine

PCL:

Polycaprolactone

PDHA:

Poly(dihydroxy acetone)

PDMA:

Poly(dimethyl acrylamide)

PDMAEMA:

Poly(dimethylaminoethyl methacrylate)

PDPA:

Poly[(2-diisopropylamino)ethyl methacrylate]

PE:

Polyethylene

PEG or PEO:

Poly(ethylene glycol)

PEI:

Polyethyleneimine

PGAH:

Poly(l-glutamic acid γ-hydrazide)

P-gp:

P-glycoprotein

PHD:

PEI-HZ-DOX

PKB:

Protein kinase B

PLGA:

Poly(lactic-co-glycolic acid)

PLL:

Poly-l-lysine

PLLD:

Poly(l-lysine) dendrimer

PLLeu:

Poly-l-leucine

PNC:

Polymer nanocapsules

PPF:

PEI-PEG-Folate

PTX:

Paclitaxel

RNAi:

RNA interference

siRNA:

Short interfering RNA

SSNP:

Supramolecular self-assembled NP

TEA:

Triethanolamine

TNF-α:

Tumor necrosis factor-α

VEGF:

Vascular endothelial growth factor

References

  1. Siegel RL, Miller KD, Jemal A (2016) CA CA Cancer J Clin 66:7

    Article  Google Scholar 

  2. Qiu LY, Bae YH (2006) Pharm Res 23:1

    Article  CAS  Google Scholar 

  3. Halama A, Kuliński M, Librowski T, Lochyński S (2009) Pharmacol Rep 61:993

    Article  CAS  Google Scholar 

  4. Satchi-Fainaro R, Duncan R, Barnes CM (2006) In: Satchi-Fainaro R, Duncan R (eds) Polymer therapeutics II. Springer, Berlin, p 1

    Chapter  Google Scholar 

  5. De Smedt SC, Demeester J, Hennink WE (2000) Pharm Res 17:113

    Article  Google Scholar 

  6. Pack DW, Hoffman AS, Pun S, Stayton PS (2005) Nat Rev Drug Discov 4:581

    Article  CAS  Google Scholar 

  7. Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N, Sarkar S (2014) Cancers 6:1769

    Article  CAS  Google Scholar 

  8. Tsouris V, Joo MK, Kim SH, Kwon IC, Won Y-Y (2014) Biotechnol Adv 32:1037

    Article  CAS  Google Scholar 

  9. Khan M, Ong ZY, Wiradharma N, Attia ABE, Yang Y-Y (2012) Adv Healthc Mater 1:373

    Article  CAS  Google Scholar 

  10. Creixell M, Peppas NA (2012) Nano Today 7:367

    Article  CAS  Google Scholar 

  11. Zhao J, Feng S-S (2015) Nanomed (London UK) 10:2199

    Article  CAS  Google Scholar 

  12. Yang Z, Gao D, Cao Z, Zhang C, Cheng D, Liu J, Shuai X (2015) Biomater Sci 3:1035

    Article  CAS  Google Scholar 

  13. Kanasty R, Dorkin JR, Vegas A, Anderson D (2013) Nat Mater 12:967

    Article  CAS  Google Scholar 

  14. Kesharwani P, Gajbhiye V, Jain NK (2012) Biomaterials 33:7138

    Article  CAS  Google Scholar 

  15. Oh Y-K, Park TG (2009) Adv Drug Deliv Rev 61:850

    Article  CAS  Google Scholar 

  16. Jeong JH, Park TG, Kim SH (2011) Pharm Res 28:2072

    Article  CAS  Google Scholar 

  17. Petersen H, Fechner PM, Martin AL, Kunath K, Stolnik S, Roberts CJ, Fischer D, Davies MC, Kissel T (2002) Bioconjugate Chem 13:845

    Article  CAS  Google Scholar 

  18. Miteva M, Kirkbride KC, Kilchrist KV, Werfel TA, Li H, Nelson CE, Gupta MK, Giorgio TD, Duvall CL (2015) Biomaterials 38:97

    Article  CAS  Google Scholar 

  19. Gallon E, Matini T, Sasso L, Mantovani G, Arminan de Benito A, Sanchis J, Caliceti P, Alexander C, Vicent MJ, Salmaso S (2015) Biomacromolecules 16:1924

    Article  CAS  Google Scholar 

  20. Xu X, Wu J, Liu Y, Yu M, Zhao L, Zhu X, Bhasin S, Li Q, Ha E, Shi J, Farokhzad OC (2016) Angew Chem Int Ed 55:7091

    Article  CAS  Google Scholar 

  21. Park TG, Jeong JH, Kim SW (2006) Adv Drug Deliv Rev 58:467

    Article  CAS  Google Scholar 

  22. Putnam D, Langer R (1999) Macromolecules 32:3658

    Article  CAS  Google Scholar 

  23. Chen C-K, Law W-C, Aalinkeel R, Nair B, Kopwitthaya A, Mahajan SD, Reynolds JL, Zou J, Schwartz SA, Prasad PN, Cheng C (2012) Adv Healthc Mater 1:751

    Article  CAS  Google Scholar 

  24. Aalinkeel R, Nair B, Chen C-K, Mahajan SD, Reynolds JL, Zhang H, Sun H, Sykes DE, Chadha KC, Turowski SG, Bothwell KD, Seshadri M, Cheng C, Schwartz SA (2016) Immunology 148:387

    Article  CAS  Google Scholar 

  25. Yin L, Zheng N, Cheng J (2016) In: Shum K, Rossi J (eds) siRNA delivery methods: methods and protocols. Springer, New York, p 37

    Chapter  Google Scholar 

  26. He H, Zheng N, Song Z, Kim KH, Yao C, Zhang R, Zhang C, Huang Y, Uckun FM, Cheng J, Zhang Y, Yin L (2016) ACS Nano 10:1859

    Article  CAS  Google Scholar 

  27. Yin L, Song Z, Qu Q, Kim KH, Zheng N, Yao C, Chaudhury I, Tang H, Gabrielson NP, Uckun FM, Cheng J (2013) Angew Chem Int Ed 52:5757

    Article  CAS  Google Scholar 

  28. Zheng N, Song Z, Liu Y, Zhang R, Zhang R, Yao C, Uckun FM, Yin L, Cheng J (2015) J Control Release 205:231

    Article  CAS  Google Scholar 

  29. Whitehead KA, Dorkin JR, Vegas AJ, Chang PH, Veiseh O, Matthews J, Fenton OS, Zhang Y, Olejnik KT, Yesilyurt V, Chen D, Barros S, Klebanov B, Novobrantseva T, Langer R, Anderson DG (2014) Nat Commun 5:4277

    Article  CAS  Google Scholar 

  30. Lee SJ, Yook S, Yhee JY, Yoon HY, Kim M-G, Ku SH, Kim SH, Park JH, Jeong JH, Kwon IC, Lee S, Lee H, Kim K (2015) J Control Release 220:631

    Article  CAS  Google Scholar 

  31. Duncan R (2003) Nat Rev Drug Discov 2:347

    Article  CAS  Google Scholar 

  32. Elsabahy M, Wooley KL (2012) Chem Soc Rev 41:2545

    Article  CAS  Google Scholar 

  33. Tong R, Cheng J (2007) Polym Rev 47:345

    Article  CAS  Google Scholar 

  34. Su H, Koo JM, Cui H (2015) J Control Release 219:383

    Article  CAS  Google Scholar 

  35. Ma W, Cheetham AG, Cui H (2016) Nano Today 11:13

    Article  CAS  Google Scholar 

  36. Duncan R (2006) Nat Rev Cancer 6:688

    Article  CAS  Google Scholar 

  37. Khandare J, Minko T (2006) Prog Polym Sci 31:359

    Article  CAS  Google Scholar 

  38. Yu Y, Chen C-K, Law W-C, Sun H, Prasad PN, Cheng C (2015) Polym Chem 6:953

    Article  CAS  Google Scholar 

  39. Zhang F, Zhang S, Pollack SF, Li R, Gonzalez AM, Fan J, Zou J, Leininger SE, Pavía-Sanders A, Johnson R, Nelson LD, Raymond JE, Elsabahy M, Hughes DMP, Lenox MW, Gustafson TP, Wooley KL (2015) J Am Chem Soc 137:2056

    Article  CAS  Google Scholar 

  40. Veronese FM, Pasut G (2005) Drug Discov Today 10:1451

    Article  CAS  Google Scholar 

  41. Mura S, Nicolas J, Couvreur P (2013) Nat Mater 12:991

    Article  CAS  Google Scholar 

  42. Chen W, Du J (2013) Sci Rep 3:2162

    Article  Google Scholar 

  43. Bae YH, Park K (2011) J Control Release 153:198

    Article  CAS  Google Scholar 

  44. Stella B, Arpicco S, Peracchia MT, Desmaële D, Hoebeke J, Renoir M, D’Angelo J, Cattel L, Couvreur P (2000) J Pharm Sci 89:1452

    Article  CAS  Google Scholar 

  45. Brannon-Peppas L, Blanchette JO (2012) Adv Drug Deliv Rev 64(Supplement):206

    Article  Google Scholar 

  46. Aina OH, Sroka TC, Chen M-L, Lam KS (2002) Peptide Sci 66:184

    Article  CAS  Google Scholar 

  47. Klonisch T, Wiechec E, Hombach-Klonisch S, Ande SR, Wesselborg S, Schulze-Osthoff K, Los M (2008) Trends Mol Med 14:450

    Article  CAS  Google Scholar 

  48. Borst P (1991) Acta Oncol 30:87

    Article  CAS  Google Scholar 

  49. Gottesman MM (2002) Annu Rev Med 53:615

    Article  CAS  Google Scholar 

  50. Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG (2013) Nat Rev Cancer 13:714

    Article  CAS  Google Scholar 

  51. Zahreddine H, Borden K (2013) Front Pharmacol 4:28

    Article  CAS  Google Scholar 

  52. Liscovitch M, Lavie Y (2002) IDrugs 5:349

    CAS  Google Scholar 

  53. Ozben T (2006) FEBS Lett 580:2903

    Article  CAS  Google Scholar 

  54. Hockenbery D, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Nature 348:334

    Article  CAS  Google Scholar 

  55. Fesik SW (2005) Nat Rev Cancer 5:876

    Article  CAS  Google Scholar 

  56. Igney FH, Krammer PH (2002) Nat Rev Cancer 2:277

    Article  CAS  Google Scholar 

  57. Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM (2006) Nat Rev Drug Discov 5:219

    Article  CAS  Google Scholar 

  58. Wu Q, Yang Z, Nie Y, Shi Y, Fan D (2014) Cancer Lett 347:159

    Article  CAS  Google Scholar 

  59. Kerr JFR, Winterford CM, Harmon BV (1994) Cancer 73:2013

    Article  CAS  Google Scholar 

  60. Bertrand J-R, Pottier M, Vekris A, Opolon P, Maksimenko A, Malvy C (2002) Biochem Biophys Res Commun 296:1000

    Article  CAS  Google Scholar 

  61. Su W-P, Cheng F-Y, Shieh D-B, Yeh C-S, Su W-C (2012) Int J Nanomed 7:4269

    Article  CAS  Google Scholar 

  62. Babu A, Wang Q, Muralidharan R, Shanker M, Munshi A, Ramesh R (2014) Mol Pharm 11:2720

    Article  CAS  Google Scholar 

  63. Zhao X, Li F, Li Y, Wang H, Ren H, Chen J, Nie G, Hao J (2015) Biomaterials 46:13

    Article  CAS  Google Scholar 

  64. Liu H, Li Y, Mozhi A, Zhang L, Liu Y, Xu X, Xing J, Liang X, Ma G, Yang J, Zhang X (2014) Biomaterials 35:6519

    Article  CAS  Google Scholar 

  65. He C, Liu D, Lin W (2015) Biomaterials 36:124

    Article  CAS  Google Scholar 

  66. He C, Poon C, Chan C, Yamada SD, Lin W (2016) J Am Chem Soc 138:6010

    Article  CAS  Google Scholar 

  67. Cao N, Cheng D, Zou S, Ai H, Gao J, Shuai X (2011) Biomaterials 32:2222

    Article  CAS  Google Scholar 

  68. Zou S, Cao N, Cheng D, Zheng R, Wang J, Zhu K, Shuai X (2012) Int J Nanomedicine 7:3823

    CAS  Google Scholar 

  69. Qian J, Xu M, Suo A, Xu W, Liu T, Liu X, Yao Y, Wang H (2015) Acta Biomater 15:102

    Article  CAS  Google Scholar 

  70. Xu M, Qian J, Suo A, Liu T, Liu X, Wang H (2015) Polym Chem 6:2445

    Article  CAS  Google Scholar 

  71. Shen J, Wang Q, Hu Q, Li Y, Tang G, Chu PK (2014) Biomaterials 35:8621

    Article  CAS  Google Scholar 

  72. Xiong X-B, Lavasanifar A (2011) ACS Nano 5:5202

    Article  CAS  Google Scholar 

  73. Amjad MW, Amin MCIM, Katas H, Butt AM, Kesharwani P, Iyer AK (2015) Mol Pharm 12:4247

    Article  CAS  Google Scholar 

  74. Dong D-W, Xiang B, Gao W, Yang Z-Z, Li J-Q, Qi X-R (2013) Biomaterials 34:4849

    Article  CAS  Google Scholar 

  75. Dong D, Gao W, Liu Y, Qi X-R (2015) Cancer Lett 359:178

    Article  CAS  Google Scholar 

  76. Zheng C, Zheng M, Gong P, Deng J, Yi H, Zhang P, Zhang Y, Liu P, Ma Y, Cai L (2013) Biomaterials 34:3431

    Article  CAS  Google Scholar 

  77. Zhu C, Jung S, Luo S, Meng F, Zhu X, Park TG, Zhong Z (2010) Biomaterials 31:2408

    Article  CAS  Google Scholar 

  78. Yu H, Xu Z, Chen X, Xu L, Yin Q, Zhang Z, Li Y (2014) Macromol Biosci 14:100

    Article  CAS  Google Scholar 

  79. Yang S-D, Zhu W-J, Zhu Q-L, Chen W-L, Ren Z-X, Li F, Yuan Z-Q, Li J-Z, Liu Y, Zhou X-F, Liu C, Zhang X-N (2016) J Biomed Mater Res B. doi:10.1002/jbm.b.33636 (Ahead of Print)

    Google Scholar 

  80. Tang S, Yin Q, Su J, Sun H, Meng Q, Chen Y, Chen L, Huang Y, Gu W, Xu M, Yu H, Zhang Z, Li Y (2015) Biomaterials 48:1

    Article  CAS  Google Scholar 

  81. Jones SK, Lizzio V, Merkel OM (2016) Biomacromolecules 17:76

    Article  CAS  Google Scholar 

  82. Liu T, Xue W, Ke B, Xie M-Q, Ma D (2014) Biomaterials 35:3865

    Article  CAS  Google Scholar 

  83. Kala S, Mak ASC, Liu X, Posocco P, Pricl S, Peng L, Wong AST (2014) J Med Chem 57:2634

    Article  CAS  Google Scholar 

  84. Biswas S, Deshpande PP, Navarro G, Dodwadkar NS, Torchilin VP (2013) Biomaterials 34:1289

    Article  CAS  Google Scholar 

  85. Sherwani MA, Tufail S, Khan AA, Owais M (2015) RSC Adv 5:39512

    Article  CAS  Google Scholar 

  86. Zhou X, Zheng Q, Wang C, Xu J, Wu J-P, Kirk TB, Ma D, Xue W (2016) ACS Appl Mater Interfaces 8:12609

    Article  CAS  Google Scholar 

  87. Chen C-K, Law W-C, Aalinkeel R, Yu Y, Nair B, Wu J, Mahajan S, Reynolds JL, Li Y, Lai CK, Tzanakakis ES, Schwartz SA, Prasad PN, Cheng C (2014) Nanoscale 6:1567

    Article  CAS  Google Scholar 

  88. Chen J, Liu Q, Xiao J, Du J (2015) Biomacromolecules 16:1695

    Article  CAS  Google Scholar 

  89. Li Z, Li J, Huang J, Zhang J, Cheng D, Shuai X (2015) Macromol Biosci 15:1497

    Article  CAS  Google Scholar 

  90. Liu C, Zhao G, Liu J, Ma N, Chivukula P, Perelman L, Okada K, Chen Z, Gough D, Yu L (2009) J Control Release 140:277

    Article  CAS  Google Scholar 

  91. Kazunori K, Glenn SK, Masayuki Y, Teruo O, Yasuhisa S (1993) J Control Release 24:119

    Article  Google Scholar 

  92. Kwon GS, Okano T (1996) Adv Drug Deliv Rev 21:107

    Article  CAS  Google Scholar 

  93. Miyata K, Christie RJ, Kataoka K (2011) React Funct Polym 71:227

    Article  CAS  Google Scholar 

  94. Hao S, Yan Y, Ren X, Xu Y, Chen L, Zhang H (2015) Biotechnol Bioprocess Eng 20:550

    Article  CAS  Google Scholar 

  95. Kesharwani P, Jain K, Jain NK (2014) Prog Polym Sci 39:268

    Article  CAS  Google Scholar 

  96. Yang J, Zhang Q, Chang H, Cheng Y (2015) Chem Rev 115:5274

    Article  CAS  Google Scholar 

  97. Sun H, Chen C-K, Cui H, Cheng C (2016) Polym Int 65:351

    Article  CAS  Google Scholar 

  98. Mora-Huertas CE, Fessi H, Elaissari A (2010) Int J Pharm 385:113

    Article  CAS  Google Scholar 

  99. Hu S-H, Chen S-Y, Gao X (2012) ACS Nano 6:2558

    Article  CAS  Google Scholar 

  100. Li Y, Liu R, Yang J, Ma G, Zhang Z, Zhang X (2014) Biomaterials 35:9731

    Article  CAS  Google Scholar 

  101. Yin T, Wang P, Li J, Wang Y, Zheng B, Zheng R, Cheng D, Shuai X (2014) Biomaterials 35:5932

    Article  CAS  Google Scholar 

  102. Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JI, Nel AE (2010) ACS Nano 4:4539

    Article  CAS  Google Scholar 

  103. Meng H, Mai WX, Zhang H, Xue M, Xia T, Lin S, Wang X, Zhao Y, Ji Z, Zink JI, Nel AE (2013) ACS Nano 7:994

    Article  CAS  Google Scholar 

  104. Chen AM, Zhang M, Wei D, Stueber D, Taratula O, Minko T, He H (2009) Small 5:2673

    Article  CAS  Google Scholar 

  105. Ma X, Zhao Y, Ng KW, Zhao Y (2013) Chem Eur J 19:15593

    Article  CAS  Google Scholar 

  106. Xiao Y, Jaskula-Sztul R, Javadi A, Xu W, Eide J, Dammalapati A, Kunnimalaiyaan M, Chen H, Gong S (2012) Nanoscale 4:7185

    Article  CAS  Google Scholar 

  107. Yin F, Yang C, Hu R, Yong K-T, Wang Q, Lu F, Zeng S, Lin G, Tian J, Hu S, Lan RF, Yoon HS, Wang K (2015) Theranostics 5:818

    Article  CAS  Google Scholar 

  108. Zhang P, Wang C, Zhao J, Xiao A, Shen Q, Li L, Li J, Zhang J, Min Q, Chen J, Chen H-Y, Zhu J-J (2016) ACS Nano 10:3637

    Article  CAS  Google Scholar 

  109. Conde J, Oliva N, Zhang Y, Artzi N (2016) Nat Mater 15:1128

    Article  CAS  Google Scholar 

  110. Wang H, Zhao P, Su W, Wang S, Liao Z, Niu R, Chang J (2010) Biomaterials 31:8741

    Article  CAS  Google Scholar 

  111. Saad M, Garbuzenko OB, Minko T (2008) Nanomedicine 3:761

    Article  CAS  Google Scholar 

  112. Anglin EJ, Cheng L, Freeman WR, Sailor MJ (2008) Adv Drug Deliv Rev 60:1266

    Article  CAS  Google Scholar 

  113. Ghosh P, Han G, De M, Kim CK, Rotello VM (2008) Adv Drug Deliv Rev 60:1307

    Article  CAS  Google Scholar 

  114. Mendonça LS, Moreira JN, de Lima MCP, Simões S (2010) Biotechnol Bioeng 107:884

    Article  CAS  Google Scholar 

  115. Wilhelm S, Tavares AJ, Dai Q, Ohta S, Audet J, Dvorak HF, Chan WCW (2016) Nat Rev Mater 1:16014

    Article  CAS  Google Scholar 

  116. Hu C, Fang R, Luk B, Zhang L (2014) Nanoscale 6:65

    Article  CAS  Google Scholar 

  117. Bertrand N, Leroux JC (2012) J Control Release 161:152

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank the US National Science Foundation for financial support (DMR-1206715, DMR-1609914). The authors also acknowledge the collaborations with all the coworkers.

Author information

Authors and Affiliations

  1. Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA

    Haotian Sun, Iven Yarovoy, Meghan Capeling & Chong Cheng

Authors
  1. Haotian Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Iven Yarovoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Meghan Capeling
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chong Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chong Cheng.

Additional information

This article is part of the Topical Collection “Polymeric Gene Delivery Systems”; edited by Yiyun Cheng.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sun, H., Yarovoy, I., Capeling, M. et al. Polymers in the Co-delivery of siRNA and Anticancer Drugs for the Treatment of Drug-resistant Cancers. Top Curr Chem (Z) 375, 24 (2017). https://doi.org/10.1007/s41061-017-0113-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s41061-017-0113-z

Keywords

Search

Navigation