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Synthesis and Spectroscopic Study of Biologically Active Tridentate Schiff’s Base Ligand 2-Acetyl-5-methyl-furanthiosemicarbazone and its Mn(II), Co(II), Ni(II), and Cu(II) Complexes

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Abstract

A novel tridentate Schiff’s base ligand 2-acetyl-5-methyl-furanthiosemicarbazone was isolated from 2-acetyl-5-methyl-furan (0.001 mol) and thiosemicarbazide (0.001 mol) in ethanolic medium in 1:1 ratio at pH 3–4. Isolated ligand was structurally characterized by melting point, elemental analysis, 1H-NMR, Mass, UV and IR studies. Mn(II), Co(II), Ni(II), and Cu(II), and metal complexes of Schiff’s base ligand were also synthesized and characterized by analytical method, melting point analysis, element analysis, molar conductance, magnetic moment and spectral studies IR, electronic spectra, and EPR spectra. On the basis of spectral studies, transition metal complexes have the general composition [ML2]Cl2 where M = Mn(II), Co(II), Ni(II), and Cu(II), L = 2-acetyl-5-methyl-furanthiosemicarbazone. Molar conductance values suggested electrolytic nature of metal complexes by the composition [ML2]Cl2. On the basis of spectral studies, six coordinated octahedral/tetragonal geometries were assigned for the synthesized complexes. Molecular modeling of ligand and complexes was also done by using Gaussian. All synthesized compounds were also examined to evaluate their antibacterial potential against bacteria E. coli and S. typhi. On the basis of antimicrobial results, it was concluded that metal complexes exhibited higher inhibition potential than free Schiff’s base ligand.

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Acknowledgements

Ms. Pallavi Goel (Jain) is thankful to Dr. (Prof) Manoj Kumar Pandey, Director, SRM University, Modinagar, for providing facilities and for his encouragements to do Ph.D. research work and publication of papers. The author is grateful to her guide and co-guide for their research guidance and proper support. The author is also thankful to IIT Bombay for recording EPR spectra, IIT Delhi, for recording NMR, Mass, and IR spectra.

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Authors and Affiliations

  1. Department of Chemistry, Banasthali University, Banasthali, Rajasthan, India

    Pallavi Goel & Dinesh Kumar

  2. Department of Chemistry, SRM University, Modinagar, India

    Pallavi Goel

  3. Department of Chemistry, Zakir Husain Delhi College (University of Delhi), New Delhi, India

    Sulekh Chandra

  4. Department of Chemistry, Dayal Singh College (University of Delhi), New Delhi, India

    Amit Kumar

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  1. Pallavi Goel
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  2. Dinesh Kumar
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  4. Amit Kumar
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Correspondence to Pallavi Goel.

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Goel, P., Kumar, D., Chandra, S. et al. Synthesis and Spectroscopic Study of Biologically Active Tridentate Schiff’s Base Ligand 2-Acetyl-5-methyl-furanthiosemicarbazone and its Mn(II), Co(II), Ni(II), and Cu(II) Complexes. Iran J Sci Technol Trans Sci 42, 557–565 (2018). https://doi.org/10.1007/s40995-016-0140-6

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  • DOI: https://doi.org/10.1007/s40995-016-0140-6

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