Abstract
Purpose
Breast cancer is the most common cancer in women. In recent research works, the role of cytokines in development of cancer has attracted attention. Therefore, this paper intends to comprehensively assess the association between breast cancer and polymorphism A/T 251 from the IL-8 gene using meta-analysis.
Methods
In this study, to find articles published electronically between 2004 and 2020, national and international databases of SID, MagIran, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS).
Results
The odds ratio of AA genotype in patients with breast cancer based was obtained as 1.42 (1.11–1.82: 95% confidence interval), which shows the increasing effect of AA genotype by 0.42, the odds ratio of the AT genotype in patients with breast cancer based on a meta-analysis of studies was obtained as 1.01 (0.84–1.22: 95% confidence interval), which demonstrates the increasing effect of the AT genotype by 0.01, and the odds ratio of the TT genotype in patients with breast cancer was similarly obtained and was 0.95 (1.08–0.24: 95% confidence limit), which shows the decreasing effect of TT genotype by 0.05.
Conclusion
According to this meta-analysis, allele A has a significant relationship with breast cancer, which can be used as a predictor of the course of the disease and the clinical outcome of breast cancer. Identifying polymorphism A/T 251 from the IL-8 gene, as a genetic marker and predictor, can also be effective in treating breast cancer.
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Datasets are available through the corresponding author upon reasonable request.
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Acknowledgements
The authors thank the Student Research Committee of Kermanshah University of Medical Sciences.
Funding
This study is funded by the Deputy for Research and Technology, Kermanshah University of Medical Sciences (990398).
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NS and KM contributed to the design, MM statistical analysis, participated in most of the study steps. MM and MK prepared the manuscript. AHF and KM and FAN assisted in designing the study and helped in the interpretation of the study. All authors have read and approved the content of the manuscript.
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Ethics approval was received from the Ethics committee of Deputy of Research and Technology, Kermanshah University of Medical Sciences (IR.KUMS.REC.1399.199).
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Salari, N., Kazeminia, M., Hosseinian-Far, A. et al. The Effect of Polymorphism A/T 251 of the IL-8 Gene on Breast Cancer: A Systematic Review and Meta-Analysis. Indian J Gynecol Oncolog 19, 70 (2021). https://doi.org/10.1007/s40944-021-00571-3
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DOI: https://doi.org/10.1007/s40944-021-00571-3