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Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

近红外或超声敏感的二维纳米材料用于癌症诊疗的研究进展

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Abstract

In recent years, the emerging two-dimensional (2D) nanomaterials have shown great potential for a variety of applications such as electronics, catalysis, supercapacitors, and energy materials. In the biomedical arena, these nanomaterials, especially 2D-ultrathin nanomaterials, have also been regarded as promising nano-carriers and/or diagnostic agents for cancer diagnosis and treatment, owing to their remarkable mechanical, photothermal, and optical properties. In this review, we provide the recent development of the nanoplatforms based on near-infrared/ultrasound-sensitive 2D-materials, representatively such as graphdiyne (GDY), black phosphorus, transition metal dichalcogenides (TMDs), and antimonene, for non-invasive cancer therapeutics including photothermal, photodynamic and sonodynamic approaches. The general properties of these 2D nanomaterials linking to biomedical interests are first introduced, followed by the fabrication processes of diverse nano-platforms and related outcomes of cancer diagnosis and treatments. We also outline the current challenges and prospects of the 2D materials for non-invasive approaches to cancer treatments in the future.

摘要

二维纳米材料在电子学、 催化、 超级电容器和能源材料等领域展现出了巨大的应用潜力. 在生物医学领域, 以二维超薄纳米材料为代表的低维材料, 因其优异的机械、 光热、 电子和光学性能, 以及良好的生物相容性和生物降解性, 被广泛用于构建多功能纳米平台并应用于肿瘤的诊疗. 本综述概述了石墨炔、 黑磷、 过渡金属二卤化物、 锑烯等新型低维材料的特定结构与性质, 详细总结了基于各类对近红外或超声敏感的材料构建的纳米平台在光热、 光动力和声动力无创肿瘤治疗中的最新进展, 并进一步探讨了纳米材料在无创式癌症治疗中所面临的挑战与应用前景.

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Acknowledgements

This work was supported by the State Key Research Development Program of China (2019YFB2203503), the National Natural Science Foundation of China (61875138, 61435010, 81972423 and 61961136001), Science and Technology Innovation Commission of Shenzhen (KQTD2015032416270385, JCYJ20170811093453105, JCYJ20180307164612205, JCYJ20170307144246792, GJHZ20180928160209731 and 202050345), the Clinical Research Startup Plan of Southern Medical University (LC2016YM018), Shenzhen Key Laboratory of Viral Oncology (ZDSYS201707311140430), the Grant of Sanming Medical Project (SM201702), and the Instrumental Analysis Center of Shenzhen University (Xili Campus).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Ultrasound, Shenzhen Hospital, Southern Medical University, Shenzhen, 518100, China

    Wei Yang  (杨微), Liqi Cao  (曹励琪) & Yi Hao  (郝轶)

  2. Institute of Microscale Optoelectronics, Collaborative Innovation Centre for Optoelectronic Science & Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China

    Qinghua Lyu  (吕庆华) & Han Zhang  (张晗)

  3. School of Ophthalmology & Optometry Affiliated to Shenzhen University, Shenzhen, 518040, China

    Qinghua Lyu  (吕庆华) & Jun Zhao  (赵军)

  4. Shenzhen Eye Institute, Shenzhen Eye Hospital Affiliated to Jinan University, Shenzhen, 518040, China

    Jun Zhao  (赵军)

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  1. Wei Yang  (杨微)
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Contributions

Author contributions Zhang H and Hao Y provided the whole concept; Zhang H wrote the abstract, introduction and conclusion sections; Yang W and Lyu Q wrote the sections of 2D-nanomaterials for PDT, PTT, and SDT; Cao L summarized the references and Zhao J revised the manuscript. All authors contributed to the general discussion.

Corresponding authors

Correspondence to Yi Hao  (郝轶) or Han Zhang  (张晗).

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Conflict of interest The authors declare that they have no conflict of interest.

Additional information

Wei Yang completed her BSc degree at Southern Medical University in 2012. Now she is pursuing her MSc degree in Southern Medical University, and her research interests focus on the biomedical applications of nanomaterials and development of functional nanostructures for cancer sonodynamic therapy.

Qinghua Lyu completed his BSc degree at China Pharmaceutical University and then obtained his PhD degree in the National University Singapore in 2019. He continued his academic research as a post-doctoral fellow in the School of Ophthalmology & Optometry Affiliated to Shenzhen University, and his research interests include medicinal chemistry, fabrication and modification of biomaterials and natural polymers for biomedical applications.

Yi Hao received his BSc degree at Xinjiang Medical University in 2004. He obtained his MSc degree at Xinjiang Medical University in 2009. Currently, he is a doctor in Shenzhen Hospital affiliated to Southern Medical University and his main research interests concern the ultrasonic diagnosis of tumor, modification and application of ultrasound microbubbles and nanomaterials in cancer therapy.

Han Zhang received his BSc degree from Wuhan University (2006) and PhD degree from Nanyang Technological University (2010). In 2012, he joined the College of Optoelectronic Engineering (Collaborative Innovation Centre for Optoelectronic Science Technology), Shenzhen University as a full professor. His current research is on the ultrafast, nonlinear photonics, and biomedicine of 2D materials.

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Yang, W., Lyu, Q., Zhao, J. et al. Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics. Sci. China Mater. 63, 2397–2428 (2020). https://doi.org/10.1007/s40843-020-1387-7

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