Abstract
Luminescent biosensing in the second nearinfrared (NIR-II) region is featured with superior spatial resolution and high penetration depth by virtue of the suppressed scattering of long-wavelength photons. Hitherto, the reported NIR-II nanoprobes are mostly based on carbon nanotubes, organic fluorophores or semiconducting quantum dots. As an alternative, trivalent lanthanide ions (Ln3+) doped nanoparticles have been emerging as a novel class of promising nanoprobes. In this review, we highlight the recent progress in the design of highly efficient Ln3+-doped NIR-II nanoparticles towards their emerging bioapplications, with an emphasis on autofluorescence-free bioimaging, sensitive bioassay, and accurate temperature sensing. Moreover, some efforts and challenges towards this rapidly expanding field are envisioned.
摘要
近红外二区(1000–1700 nm)荧光纳米探针可以显著降低穿透组织时的光散射和自荧光效应的影响, 从而提高探测深度以及 成像分辨率. 目前已报道的近红外二区生物探针主要基于有机荧光团、 碳纳米管、 量子点以及共轭聚合物. 稀土离子掺杂纳米晶因其优异的发光性质, 被认为是一类极具发展潜力的生物探针. 本文从设计高效近红外二区发光的稀土掺杂纳米材料的角度出发, 主要介绍了此类稀土纳米探针的基质选择、 阳离子掺杂和表面修饰等设计策略的研究进展, 及其在无背景生物成像, 高灵敏生物检测和温度探测等领域的最新应用. 此外, 还展望了此类荧光纳米探针面临的挑战以及未来发展趋势.
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Acknowledgements
This work was supported by the Strategic Priority Research Program of the CAS (XDB20000000), the National Natural Science Foundation of China (21771185, 11704380, 51672272, 21804134 and U1805252), the CAS/SAFEA International Partnership Program for Creative Research Teams, and Natural Science Foundation of Fujian Province (2017I0018).
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Shaohua Yu earned her BSc degree from Fuzhou University (2015). She is currently a PhD student in condensed matter physics in the University of Chinese Academy of Sciences (UCAS). In September 2015, she joined Prof. Xueyuan Chen’s group in Fujian Institute of Research on the Structure of Matter (FJIRSM). Her current research focuses on the controlled synthesis and optical spectroscopy of inorganic luminescent nanomaterials.
Datao Tu earned his BSc degree (2006) from Wuhan University of Technology. He received his PhD degree (2011) in materials physics and chemistry from FJIRSM, Chinese Academy of Sciences. He joined Prof. Xueyuan Chen’s group as a research assistant professor in July 2011 and was promoted to research associate professor in 2014. His research focuses on the chemical synthesis, optical spectroscopy and biodetection of lanthanide-doped nanoprobes.
Xueyuan Chen earned his BSc degree from the University of Science and Technology of China (1993) and his PhD degree from FJIRSM, Chinese Academy of Sciences (1998). From 2001 to 2005, he was a postdoctoral research associate at the Chemistry Division of Argonne National Laboratory, U.S. Department of Energy, where he studied the photophysics and photochemistry of heavy elements. In 2005, he joined the faculty at FJIRSM, where he is currently professor and group leader in Material Chemistry and Physics. His research focuses on the chemistry, optical spectroscopy and bioapplications of lanthanide-doped luminescent nanomaterials.
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Yu, S., Tu, D., Lian, W. et al. Lanthanide-doped near-infrared II luminescent nanoprobes for bioapplications. Sci. China Mater. 62, 1071–1086 (2019). https://doi.org/10.1007/s40843-019-9414-4
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DOI: https://doi.org/10.1007/s40843-019-9414-4