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Controllable synthesis of hollow porous silica nanotubes/CuS nanoplatform for targeted chemo-photothermal therapy

可控合成空心多孔氧化硅纳米管/CuS体系应用于化疗-光热靶向治疗

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Abstract

The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent years. In this work, a nanoplatform for chemo-photothermal therapy with targeting ligand was developed. Hollow porous structured silica nanotubes (SNTs) with controllable lengths decorated with CuS nanoparticles (NPs) on the surface as photothermal agents were prepared and further conjugated with lactobionic acid groups as a cancer cell target. SNTs with average lengths of 40, 55 and 150 nm were obtained and further functionalized as drug carriers. The smallest bifunctional SNTs with targeting groups show good biocompatibility and highest cellular uptake for HepG2 cells. The release of doxorubicin hydrochloride (DOX) from the SNTs was dependent on the pH of the buffer solution and 808-nm near infrared (NIR) light irradiation. The integration of photothermal therapy (PTT) of CuS NPs and chemotherapy of anticancer drug leads to a better tumor inhibition effect than the individual therapy alone in vitro and in vivo. These results demonstrate potential applications of the nanocomposites as vector for efficient chemo-photothermal therapy.

摘要

多功能药物载体的设计合成并应用于肿瘤的联合治疗得到了研究人员的广泛关注. 本文介绍了一种连接靶向基团的化疗-光热联合治疗纳米平台. 首先制备了尺寸可控的平均长度为40、 55和150 nm的空心多孔氧化硅纳米管, 在表面修饰具有光热功能的硫化铜纳米颗粒, 然后连接乳糖酸基团实现肝癌细胞靶向功能. 平均长度为40 nm、 修饰靶向基团的空心多孔材料显示出良好的生物相容性, 且具有最大的HepG2细胞吞噬量. 负载盐酸阿霉素的纳米复合材料表现出pH和808 nm近红外激光刺激响应的释放效果. 将CuS光热治疗和盐酸阿霉素化疗相结合的方法在体外和体内的抑制肿瘤效果都优于单独治疗. 研究结果表明, 该纳米复合材料在化疗-光热联合治疗方面具有潜在的应用价值.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (NSFC, 51572257, 51720105015, 51672269, 51929201, 51922097, 51772124 and 51872282), the Science and Technology Cooperation Project between Chinese and Australian Governments (2017YFE0132300), the Key Research Program of Frontier Sciences, CAS (YZDY-SSW-JSC018), the Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund (21728101), the CAS-Croucher Funding Scheme for Joint Laboratories (CAS18204), Jiangmen Innovative Research Team Program (2017), and the Major Program of Basic Research and Applied Research of Guangdong Province (2017KZDXM083)

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Authors and Affiliations

  1. College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, 463000, China

    Shanshan Huang  (黄珊珊)

  2. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Ping’an Ma  (马平安), Yi Wei  (韦祎), Ziyong Cheng  (程子泳), Bei Liu  (刘蓓), Xiaoran Deng  (邓晓然), Zhongxi Xie  (谢忠曦) & Jun Lin  (林君)

  3. School of Applied Physics and Materials, Wuyi University, Jiangmen, 529020, China

    Jun Lin  (林君)

  4. School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore

    Bengang Xing  (邢本刚)

Authors
  1. Shanshan Huang  (黄珊珊)
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  2. Ping’an Ma  (马平安)
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  3. Yi Wei  (韦祎)
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  4. Ziyong Cheng  (程子泳)
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  5. Bei Liu  (刘蓓)
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  6. Xiaoran Deng  (邓晓然)
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  7. Zhongxi Xie  (谢忠曦)
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  8. Bengang Xing  (邢本刚)
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  9. Jun Lin  (林君)
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Contributions

Author contributions Huang S performed the experiments and wrote the draft of manuscript. Liu B, Deng X and Xie Z helped design the cell and animal experiments. Wei Y contributed to the CLSM image and analysis. Ma P, Cheng Z and Xing B provided suggestions and comments on the manuscript. Lin J proposed the project and revised the manuscript.

Corresponding authors

Correspondence to Shanshan Huang  (黄珊珊), Ziyong Cheng  (程子泳) or Jun Lin  (林君).

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Conflict of interest The authors declare that they have no conflict of interest.

Additional information

Shanshan Huang received her PhD degree in inorganic chemistry from the University of Chinese Academy of Sciences in 2013. She worked in Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS) from 2006 to 2018. Currently, she is an associate professor in the College of Chemistry and Pharmaceutical Engineering, Huanghuai University. Her research interests include multifunctional mesoporous silica materials for drug delivery systems and rare-earth doped luminescent materials.

Ziyong Cheng received his BSc degree in materials engineering from Changchun University of Technology in 1994 and his PhD degree from CIAC, CAS in 2006. Following postdoctoral studies at Max-Planck Institute for Polymer Research (Mainz, Germany), he returned to CIAC (2008) to take up an associate professor position in inorganic chemistry. In 2013, he was promoted to a full professor. His research interests are nanostructured materials including perovskite quantum dots in photoelectric applications and polymer-inorganic nanocomposites for biomaterial related fields.

Jun Lin received his BSc and MSc degrees in inorganic chemistry from Jilin University in 1989 and 1992, respectively, and a PhD degree (inorganic chemistry) from CIAC, CAS in 1995. He worked as a postdoctoral researcher for more than 4 the years in City University of Hong Kong (1996), Institute of New Materials (Germany, 1997), Virginia Commonwealth University (USA, 1998), and University of New Orleans (USA, 1999). He is a professor at the CIAC, CAS. His research interests include luminescent materials and multifunctional composite materials toward their application in display, lighting and biomedical fields.

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Huang, S., Ma, P., Wei, Y. et al. Controllable synthesis of hollow porous silica nanotubes/CuS nanoplatform for targeted chemo-photothermal therapy. Sci. China Mater. 63, 864–875 (2020). https://doi.org/10.1007/s40843-019-1235-1

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