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Transcriptional Regulation of Stem Cell and Cancer Stem Cell Metabolism

  • Metabolism and Stem Cells (D Nakada, Section Editor)
  • Published:
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Abstract

Purpose of Review

Metabolism is increasingly recognized as a major player in control of stem cell function and fate. How stem cell metabolism is established, maintained, and regulated is a fundamental question of biology and medicine. In this review, we discuss major metabolic programs in stem cells and cancer stem cells, with a focus on key transcription factors that shape the stem cell metabolic phenotype.

Recent Findings

Cancer stem cells primarily use oxidative phosphorylation for energy generation, in contrast to normal stem cells, which rely on glycolytic metabolism with the exception of mouse embryonic stem cells. Transcription factors control the metabolic phenotype of stem cells by modulating the expression of enzymes and thus the activity of metabolic pathways. It is evident that HIF1α and PGC1α function as master regulators of glycolytic and mitochondrial metabolism, respectively.

Summary

Transcriptional regulation is a key mechanism for establishing specific metabolic programs in stem cells and cancer stem cells.

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Acknowledgments

H.-F.D. is supported by a grant from the US National Institutes of Health (R01CA190429).

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Authors and Affiliations

  1. Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA

    Ahmet Alptekin, Bingwei Ye & Han-Fei Ding

  2. Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA

    Ahmet Alptekin & Han-Fei Ding

  3. Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA

    Han-Fei Ding

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  1. Ahmet Alptekin
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  2. Bingwei Ye
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  3. Han-Fei Ding
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Correspondence to Han-Fei Ding.

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Ahmet Alptekin, Bingwei Ye, and Han-Fei Ding declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Metabolism and Stem Cells

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Alptekin, A., Ye, B. & Ding, HF. Transcriptional Regulation of Stem Cell and Cancer Stem Cell Metabolism. Curr Stem Cell Rep 3, 19–27 (2017). https://doi.org/10.1007/s40778-017-0071-y

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