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Overview: a Framework for the Discussion of Sleep in Multiple Sclerosis

  • Sleep Related Breathing Disorders (MS Badr, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review will focus on the causes, consequences, workup, and treatment of sleep-disordered breathing, insomnia, and restless legs syndrome in patients with MS. An approach to the discussion of sleep problems and associated symptoms with MS patients, to facilitate timely and accurate diagnosis, is emphasized.

Recent Findings

Recent research suggests that sleep-disordered breathing, insomnia, and restless legs syndrome disproportionately affect patients with MS and contribute to substantial morbidity in this population.

Summary

Sleep-disordered breathing, insomnia, and restless legs syndrome are common but frequently under-recognized conditions in patients with MS. Additional efforts are needed to incorporate discussions about sleep into the clinical evaluation of MS patients. Neuroanatomical features, concomitant comorbidities, and medications associated with MS may partially explain the high prevalence of these disorders in MS. Prompt identification and treatment of sleep disorders may reduce fatigue, and a thorough discussion with the MS patient about their sleep will facilitate fatigue management. Research that further characterizes recently identified relationships between sleep disturbances and other chronic symptoms in MS such as pain, depression, and cognitive dysfunction could identify new pathways to improve some of the most debilitating symptoms of MS.

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Authors and Affiliations

  1. University of Michigan Multiple Sclerosis and Sleep Disorders Centers, C728 Med-Inn Building, 1500 E. Medical Center Drive, Ann Arbor, MI, USA

    Tiffany J. Braley

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  1. Tiffany J. Braley
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Correspondence to Tiffany J. Braley.

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Conflict of Interest

Tiffany J. Braley reports grants from National MS Society and American Sleep Medicine Foundation, which fund sleep research. She also reports material support from Biogen-Idec for a recently completed sleep apnea trial. In addition, Dr. Braley is named in a provisional patent, held by the University of Michigan, concerning treatment for sleep apnea.

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This article is part of the Topical Collection on Sleep Related Breathing Disorders

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Braley, T.J. Overview: a Framework for the Discussion of Sleep in Multiple Sclerosis. Curr Sleep Medicine Rep 3, 263–271 (2017). https://doi.org/10.1007/s40675-017-0092-1

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