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Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial

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Abstract

Background

Pentoxifylline could reduce proteinuria and slow renal disease progression. We previously conducted a single-blind, randomized, controlled trial that showed that pentoxifylline decreases inflammatory markers and stabilizes renal function.

Setting and Participants

91 participants (46 in the pentoxifylline group and 45 in the control group) followed up for 7 additional years.

Study design

Post hoc analysis of a long-term follow-up after completion of the 12-months trial.

Intervention

Pentoxifylline treatment (400 mg/twice a day) or standard treatment.

Outcome

Renal event (defined as starting dialysis therapy and/or doubling serum creatinine and/or ≥ 50% decrease in estimated glomerular filtration rate) and cardiovascular mortality.

Results

During follow-up, a renal event was recorded in 24 patients from control group (13 initiated dialysis therapy and serum creatinine doubled in 11) and 11 patients from PTF group (7 initiated dialysis and serum creatinine doubled in 4) (log Rank: 5.822, p = 0.016). The possible protector effect of PTF was more significant in albuminuric patients and was independently of diabetes mellitus presence. Treatment with PTF reduced the renal events by 35% compared to the control group in a Cox model adjusted for diabetes mellitus, albuminuria and basal renal function (HR 0.65 (0.45–0.94), p = 0.022). Cardiovascular mortality was significantly reduced in PTF treatment (2 patients vs. 10 in control group) (log Rank 5.0977, p = 0.024). PTF treatment reduced cardiovascular mortality in 55% adjusted for diabetes mellitus and age (HR 0.45 (0.21–0.98), p = 0.044) (Table 3).

Limitations

Small sample size, single center, not double blind and post hoc follow-up analysis.

Conclusions

Long-term treatment with pentoxifylline may slow the rate of progression of kidney disease and reduce cardiovascular risk.

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Funding

MG, and JL are supported by ISCIII RETIC REDINREN RD016/009 and FEDER funds

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Authors and Affiliations

  1. Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain

    Alejandra Muñoz de Morales, Marian Goicoechea, Eduardo Verde, Javier Carbayo, Diego Barbieri, Andrés Delgado, Ursula Verdalles, Ana Perez de Jose & José Luño

  2. Spanish Kidney Research Network (REDINREN), FEDER FUND, Madrid, Spain

    Marian Goicoechea, Andrés Delgado & José Luño

Authors
  1. Alejandra Muñoz de Morales
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  2. Marian Goicoechea
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  3. Eduardo Verde
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  4. Javier Carbayo
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  5. Diego Barbieri
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  6. Andrés Delgado
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  7. Ursula Verdalles
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  8. Ana Perez de Jose
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  9. José Luño
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Corresponding author

Correspondence to Marian Goicoechea.

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Conflict of interest

The authors declare that they have no conflicto of interest.

Ethical approval

The study was approved by the local Institutional Ethics Commitee.

Informed consent

Informed consent was obtained from all individual participants included in the study accordance with 1964 Helsinki Declaration.

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de Morales, A.M., Goicoechea, M., Verde, E. et al. Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial. J Nephrol 32, 581–587 (2019). https://doi.org/10.1007/s40620-019-00607-0

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  • DOI: https://doi.org/10.1007/s40620-019-00607-0

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