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The use of bone mineral density measured by dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed microtomography in chronic kidney disease

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Abstract

Chronic kidney disease (CKD) is a risk factor for fractures. The current evaluation of fracture risk is based upon the combination of various clinical factors and quantitative imaging of bone. X-ray-based tools were developed to evaluate bone status and predict fracture risk. Dual energy X-ray absorptiometry (DXA) is available worldwide. Longitudinal studies showed that low areal Bone Mineral Density (BMD) measured by DXA predicts fractures in the CKD population as it does in non uremic populations, with good specificity and moderate sensitivity. Peripheral quantitative computed tomography (pQCT) and high resolution pQCT are research tools which measure volumetric BMD at the tibia and radius. They are able to discriminate between the cortical and trabecular envelopes which are differentially affected by renal osteodystrophy. In CKD, a rapid thinning and increased porosity at the cortex is observed which is associated with increased the risk for fracture.

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Authors and Affiliations

  1. INSERM 1059, SAINBIOSE, Université de Lyon, CHU 42023-42055, Saint-Etienne Cedex 2, France

    Martin Jannot, Vanessa Lapierre & Marie-Helene Lafage-Proust

  2. Centre de Recherche du CHU de Québec, Hôpital Hôtel-Dieu de Québec, Division of Nephrology and Endocrinology, Laval University, 0877, 10 McMahon, Québec City, Québec, G1R 2J6, Canada

    Fabrice Mac-Way

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  1. Martin Jannot
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  2. Fabrice Mac-Way
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  3. Vanessa Lapierre
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Correspondence to Marie-Helene Lafage-Proust.

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Jannot, M., Mac-Way, F., Lapierre, V. et al. The use of bone mineral density measured by dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed microtomography in chronic kidney disease. J Nephrol 30, 635–643 (2017). https://doi.org/10.1007/s40620-017-0433-7

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  • DOI: https://doi.org/10.1007/s40620-017-0433-7

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