Abstract
Purpose
Irisin is a newly identified myokine secreted by skeletal muscle and has significant effects on body metabolism. Thyroidal functional state has a profound influence on the metabolism of human body. Therefore, the aim of this study was to investigate the possible changes in serum irisin concentrations before and after treatment in hypothyroid subjects.
Methods
The study included 26 patients with overt hypothyroidism due to Hashimoto thyroiditis and 19 healthy subjects. Baseline serum thyroid function tests and presence of thyroid autoantibodies and levels of creatine kinase (CK) and irisin were measured in both groups. All measurements in the hypothyroid group were repeated after euthyroidism was achieved.
Results
Serum irisin levels were significantly lower in the hypothyroid groups than the control group (p < 0.001). Negative correlation between irisin and thyroid stimulating hormone and CK levels (r = − 0.623, p < 0.001 and r = − 0.389, p = 0.008, respectively) and a positive correlation between irisin and free thyroxine (fT4) levels (r = 0.570, p < 0.001) was found. Serum CK levels decreased significantly after treatment (p < 0.001). Serum irisin levels significantly increased (from 57.4 to 99.8 U/L, p < 0.001) when the hypothyroid patients were treated to achieve euthyroidism.
Conclusions
To the best of our knowledge, this is the first study providing insight that low serum irisin levels significantly increased following treatment to euthyroid state in overt hypothyroid patients with Hashimoto thyroiditis. Larger scale studies are needed to confirm these results and to ensure irisin as a possible biomarker of Hashimoto’s thyroiditis.
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References
Silva JE (1995) Thyroid hormone control of thermogenesis and energy balance. Thyroid 5:481–492
Simonides WS, van Hardeveld C (2008) Thyroid hormone as a determinant of metabolic and contractile phenotype of skeletal muscle. Thyroid 18:205e216
Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM (2012) A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–468
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS (2012) FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metab Clin Exp 61:1725–1738
Moon HS, Mantzoros CS (2014) Regulation of cell proliferation and malignant potential by irisin in endometrial, colon, thyroid and esophageal cancer cell lines. Metab Clin Exp 63:188–193
Roca-Rivada A, Castelao C, Senin LL, Landrove MO, Baltar J, Belen Crujeiras A, Seoane LM, Casanueva FF, Pardo M (2013) FNDC5/irisin is not only a myokine but also an adipokine. PLoS ONE 8:e60563
Aydin S (2014) Three new players in energy regulation: preptin, adropin and irisin. Peptides 56:94–110
Lahesmaa M, Orava J, Schalin-Jantti C, Soinio M, Hannukainen JC, Noponen T, Kirjavainen A, Iida H, Kudomi N, Enerback S, Virtanen KA, Nuutila P (2014) Hyperthyroidism increases brown fat metabolism in humans. J Clin Endocrinol Metab 99:E28–E35
Lapa C, Maya Y, Wagner M, Arias-Loza P, Werner RA, Herrmann K, Higuchi T (2015) Activation of brown adipose tissue in hypothyroidism. Ann Med 47:538–545
Visser WE, Heemstra KA, Swagemakers SM, Ozgur Z, Corssmit EP, Burggraaf J, van Ijcken WF, van der Spek PJ, Smit JW, Visser TJ (2009) Physiological thyroid hormone levels regulate numerous skeletal muscle transcripts. J Clin Endocrinol Metab 94:3487–3496
Salvatore D, Simonides WS, Dentice M, Zavacki AM, Larsen PR (2014) Thyroid hormones and skeletal muscle—new insights and potential implications. Nat Rev Endocrinol 10:206–214
Ates I, Altay M, Topcuoglu C, Yilmaz FM (2016) Circulating levels of irisin is elevated in hypothyroidism, a case-control study. Arch Endocrinol Metab 60:95–100
Ruchala M, Zybek A, Szczepanek-Parulska E (2014) Serum irisin levels and thyroid function-newly discovered association. Peptides 60:51–55
Panagiotou G, Pazaitou-Panayiotou K, Paschou SA, Komninou D, Kalogeris N, Vryonidou A, Mantzoros CS (2016) Changes of thyroid hormone levels within the normal and/or subclinical hyper- or hypothyroid range do not affect circulating irisin levels in humans. Thyroid 26(8):1039–1045
Zybek-Kocik A, Sawicka-Gutaj N, Wrotkowska E, Sowinski J, Ruchala M (2016) Time-dependent irisin concentration changes in patients affected by overt hypothyroidism. Endokrynol Pol 67(5):476–480
Zybek-Kocik A, Sawicka-Gutaj N, Szczepanek-Parulska E, Andrusiewicz M, Waligórska-Stachura J, Białas P, Krauze T, Guzik P, Skrobisz J, Ruchała M (2017) The association between irisin and muscle metabolism in different thyroid disorders. Clin Endocrinol. https://doi.org/10.1111/cen.13527
Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioural, and biomedical sciences. Behav Res Methods 39(2):175–191
Sforza N, Rosenfarb J, Rujelman R, RosmarinM Blanc E, Frigerio C, Fossati P, Caruso D, Faingold C, Meroño T, Brenta G (2017) Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis. J Endocrinol Invest 40:1303–1310. https://doi.org/10.1007/s40618-017-0690-2
Roberts MD, Bayless DS, Company JM, Jenkins NT, Padilla J, Childs TE, Martin JS, Dalbo VJ, Booth FW, Rector RS, Laughlin MH (2013) Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats. Metabolism 62:1052–1056
Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF (2013) Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity—correlation with body mass index. Peptides 39:125–130
Gouni-Berthold I, Berthold HK, Huh JY, Berman R, Spenrath N, Krone W, Mantzoros CS (2013) Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo. PLoS ONE. https://doi.org/10.1371/journal.pone.0072858
Ellefsen S, Vikmoen O, Slettaløkken G, Whist JE, Nygaard H, Hollan I, Rauk I, Vegge G, Strand TA, Raastad T, Rønnestad BR (2014) Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women. Eur J Appl Physiol 114(9):1875–1888
Samy DM, Ismail CA, Nassra RA (2015) Circulating irisin concentrations in rat models of thyroid dysfunction—effect of exercise. Metabolism 64(7):804–813
Baird MF, Graham SM, Baker JS, Bickerstaff GF (2012) Creatine-kinase- and exercise-related muscle damage implications for muscle performance and recovery. J Nutr Metab. https://doi.org/10.1155/2012/960363
Gallo D, Piantanida E, Veronesi G, Lai A, Sassi L, Lombardi V, Masiello E, Premoli P, Bianconi E, Cusini C, Rosetti S, Tanda ML, Toniolo A, Ferrario M, Bartalena L (2017) Physical performance in newly diagnosed hypothyroidism: a pilot study. J Endocrinol Invest 40:1099–1106. https://doi.org/10.1007/s40618-017-0661-7
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The authors wish to thank all the subjects, whose acceptance of this study made it possible, and the various persons in administrative positions, and ethics committee.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Informed consent was obtained from all individual participants included in the study.
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Uc, Z.A., Gorar, S., Mizrak, S. et al. Irisin levels increase after treatment in patients with newly diagnosed Hashimoto thyroiditis. J Endocrinol Invest 42, 175–181 (2019). https://doi.org/10.1007/s40618-018-0899-8
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DOI: https://doi.org/10.1007/s40618-018-0899-8