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The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines

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Abstract

Purpose

This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines.

Methods

In this comparative case–control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. They were further divided into two subgroups of overweight/obese and normal weight. The interactive effect of the PCOS status and obesity status on the circulating levels of adipokines was assessed using general linear model with the adjustment of age.

Results

A statistically significant negative interaction was reported between obesity status and PCOS status in the determination of serum adiponectin and resistin concentrations (effect size = −0.14, interaction P = 0.001, effect size = −0.15, P = 0.016). It indicated that adiponectin and resistin were significantly decreased in overweight/obese patients with PCOS compared with other subgroups. Statistically significant positive interactive effects were found between PCOS status obesity status and leptin (effect size = 0.321, interaction P = 0.036), indicating that the overweight/obese women with PCOS had the higher levels of leptin compared with the control group. Also, no interaction was reported between PCOS status and obesity status with regard to the serum levels of other adipokines.

Conclusions

While no sufficient evidence is available with regard to the causal association between adipokines and PCOS, they may contribute to the development of PCOS and regarded as the novel biomarkers of PCOS.

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Acknowledgements

This study was financially supported by Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, P.O. Box: 19395-4763, Tehran, Iran

    S. Behboudi-Gandevani, F. Ramezani Tehrani & M. Noroozzadeh

  2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    R. Bidhendi Yarandi

  3. Cellular & Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    M. Hedayati

  4. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    F. Azizi

Authors
  1. S. Behboudi-Gandevani
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  2. F. Ramezani Tehrani
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  3. R. Bidhendi Yarandi
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  4. M. Noroozzadeh
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  5. M. Hedayati
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  6. F. Azizi
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Corresponding author

Correspondence to F. Ramezani Tehrani.

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Conflict of interest

This study was supported by a research grant of Reproductive Endocrine Research Center, research institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences.

Ethical approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Behboudi-Gandevani, S., Ramezani Tehrani, F., Bidhendi Yarandi, R. et al. The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines. J Endocrinol Invest 40, 859–866 (2017). https://doi.org/10.1007/s40618-017-0650-x

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  • DOI: https://doi.org/10.1007/s40618-017-0650-x

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