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A reappraisal of vitamin D effect on non-skeletal targets and mortality

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References

  1. Romagnoli E, Pepe J, Piemonte S, Cipriani C, Minisola S (2013) Management of endocrine disease: value and limitations of assessing vitamin D nutritional status and advised levels of vitamin D supplementation. Eur J Endocrinol 169:R59–69

    Article  CAS  PubMed  Google Scholar 

  2. Heaney RP (2014) Toward a physiological referent for the vitamin D requirement. J Endocrinol Invest 37:1127–1130

    Article  CAS  PubMed  Google Scholar 

  3. Minisola S, Romagnoli E, Scillitani A, Rao SD (2014) Hypovitaminosis D in primary hyperparathyroidism: to treat or not to treat? That is the question. J Endocrinol Invest 37:413–414

    Article  PubMed  Google Scholar 

  4. Cipriani C, Romagnoli E, Carnevale V et al (2013) Effect of a single oral dose of 600,000 IU of cholecalciferol on muscle strength: a study in young women. J Endocrinol Invest 36:1051–1054

    CAS  PubMed  Google Scholar 

  5. Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP (2014) Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ 348:g2035

    Article  PubMed Central  PubMed  Google Scholar 

  6. Romagnoli E, Carnevale V, Biondi P, Minisola S (2014) Vitamin D supplementation: when and how? J Endocrinol Invest 37:603–607

    Article  PubMed  Google Scholar 

  7. De Luca F, Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15:2579–2585

    Article  Google Scholar 

  8. Al-Daghri NM, Al-Attas OS, Alokail MS et al (2013) Hypovitaminosis D associations with adverse metabolic parameters are accentuated in patients with Type 2 diabetes mellitus: a body mass index-independent role of adiponectin? J Endocrinol Invest 36:1–6

    CAS  PubMed  Google Scholar 

  9. Ju SY, Jeong HS, Kim DH (2014) Blood vitamin D status and metabolic syndrome in the general population: a dose-response meta-analysis. J Clin Endocrinol Metab 99:1053–1063

    CAS  PubMed  Google Scholar 

  10. Song HR, Park CH (2013) Low serum vitamin D level is associated with high risk of metabolic syndrome in post-menopausal women. J Endocrinol Invest 36:791–796

    Article  CAS  PubMed  Google Scholar 

  11. Afzal S, Bojesen SE, Nordestgaard BG (2013) Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis. Clin Chem 59:381–391

    Article  CAS  PubMed  Google Scholar 

  12. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG (2014) Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol 2:298–306

    Article  CAS  PubMed  Google Scholar 

  13. Afzal S, Nordestgaard BJ (2014) Low vitamin D and hypertension: a causal association? Lancet Diabetes Endocrinol 2:682–684

    Article  PubMed  Google Scholar 

  14. Avenell A, Cook JA, Maclennan GS, Macpherson GC (2007) 9 Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing 36:574–577

    Article  PubMed  Google Scholar 

  15. Wongwiwatthananukit S, Sansanayudh N, Phetkrajaysang N, Krittiyanunt S (2013) Effects of vitamin D(2) supplementation on insulin sensitivity and metabolic parameters in metabolic syndrome patients. J Endocrinol Invest 36:558–563

    CAS  PubMed  Google Scholar 

  16. Krul-Poel YH, Westra S, Ten Boekel E et al (2015) Effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes (SUNNY Trial): a randomized placebo-controlled trial. Diabetes Care 38:1420–1426

    Article  PubMed  Google Scholar 

  17. George PS, Pearson ER, Witham MD (2012) Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med 29:e142–150

    Article  CAS  PubMed  Google Scholar 

  18. Chowdhury R, Kunutsor S, Vitezova A et al (2014) Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ 348:g1903

    Article  PubMed Central  PubMed  Google Scholar 

  19. Bjelakovic G, Gluud LL, Nikolova D, et al (2014) Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev 1: CD007470

  20. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG (2014) Genetically low vitamin D concentrations and increased mortality: mendelian randomisation analysis in three large cohorts. BMJ 349:g6330

    Article  PubMed Central  PubMed  Google Scholar 

  21. Bouillon R, Carmeliet G, Verlinden L et al (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726–776

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Minisola S, Cipriani C, Piemonte S, Scillitani A, Pepe J (2014) Vitamin D: not all is bad. J Endocrinol Invest 37:1015–1016

    Article  CAS  PubMed  Google Scholar 

  23. Reid IR (2015) Effects of vitamin D supplements on bone density. J Endocrinol Invest 38:91–94

    Article  PubMed  Google Scholar 

  24. Minisola S, Pepe J, Cipriani C, Scillitani A, Piemonte S (2014) Vitamin D: is evidence of absence, absence of evidence? Osteoporos Int 25:2499–2500

    Article  CAS  PubMed  Google Scholar 

  25. Manson JE, Bassuk SS, Lee IM et al (2012) The Vitamin D and OmegA-3 Trial (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 33:159–171

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Finnish Vitamin D Trial (FIND) ClinicalTrials.gov Identifier:NCT01463813

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Authors and Affiliations

  1. Department of Internal Medicine and Medical Disciplines, “Sapienza” Rome University, Via del Policlinico 155, 00161, Rome, Italy

    S. Minisola, C. Cipriani, M. Cilli & J. Pepe

  2. Unit of Endocrinology, “Casa Sollievo della Sofferenza” Hospital, IRCCS, San Giovanni Rotondo, FG, Italy

    A. Scillitani

Authors
  1. S. Minisola
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  2. C. Cipriani
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  3. M. Cilli
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  4. A. Scillitani
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  5. J. Pepe
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Corresponding author

Correspondence to S. Minisola.

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Minisola, S., Cipriani, C., Cilli, M. et al. A reappraisal of vitamin D effect on non-skeletal targets and mortality. J Endocrinol Invest 38, 1239–1241 (2015). https://doi.org/10.1007/s40618-015-0387-3

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  • DOI: https://doi.org/10.1007/s40618-015-0387-3

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