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Hypothesized Explanations for the Observed Lung Cancer Survival Benefit Among Hispanics/Latinos in the United States

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Abstract

Hispanic/Latino ethnicity is associated with improved survival from non-small cell lung cancer compared to that for non-Hispanic Whites even though Hispanics/Latinos are more likely to potentially have inferior access-to-care and experience greater health disparities. To this end, we conducted a literature review to identify possible explanations for this survival benefit, including the role of chronic obstructive pulmonary disease and cardiovascular diseases, genetic variation, cultural influences, and immigration factors. Overall, intermittent smoking patterns, genetic variation, co-morbidities, and cultural influences were all factors likely to partially explain this survival benefit. On the other hand, immigration factors, acculturation, and access-to-care were less likely to support the survival advantage. Future research should analyze relevant Hispanic/Latino subgroups (e.g., Mexican, Puerto Rican, Cuban, Dominican, Central American, South American) and specifically focus on the relationship between Hispanic/Latino ethnicity and different lung cancer subtypes. If the Hispanic/Latino mortality benefit observed in lung cancer truly exists, a better understanding of the underlying mechanism(s) may help extend these benefits to other ethnic and racial groups.

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Funding

This study was funded in part by the Albert Einstein College of Medicine Global Health Center.

Author information

Authors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, NY, USA

    Emily Miao, Thomas Rohan & H. Dean Hosgood III

  2. New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY, USA

    Madelyn Klugman

  3. Department of Epidemiology and Population Health, Division of Epidemiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 1309, Bronx, NY, 10461, USA

    H. Dean Hosgood III

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  1. Emily Miao
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Material preparation, and data collection and synthesis were performed by Emily Miao and H Dean Hosgood. The first draft of the manuscript was written by Emily Miao and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.

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Correspondence to H. Dean Hosgood III.

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Miao, E., Klugman, M., Rohan, T. et al. Hypothesized Explanations for the Observed Lung Cancer Survival Benefit Among Hispanics/Latinos in the United States. J. Racial and Ethnic Health Disparities 10, 1339–1348 (2023). https://doi.org/10.1007/s40615-022-01319-1

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