Abstract
Background
Previous studies showed a strong relationship between reduction of appendicular muscle mass and worsening disability; hence, accuracy in assessing muscle mass is considered a key feature for a sarcopenia screening tool.
Aim
The aim of the study was to evaluate if the 7 items of Mini Sarcopenia Risk Assessment (MSRA) questionnaire predict muscle mass loss in a population of community-dwelling elderly subjects over a 5.5-y follow-up.
Methods
The study included 159 subjects, 92 women and 67 men aged 71.5 ± 2.2 years and with mean body mass index of 26.7 ± 4.0 kg/m2. Appendicular skeletal muscle mass (ASMM) as measured with Dual-Energy X-ray absorptiometry (DXA), was obtained at baseline and after 2 and 5.5 years of follow-up where the skeletal muscle index (SMI) was calculated.
Results
A significant reduction of ASMM and SMI was observed at two and 5.5 years of follow-up, in both, men and women. Repeated-measures analysis of variance (ANOVA) found a significant time effect on ASMM for both subjects with MSRA > 30 and ≤ 30 (P < 0.01 and P < 0.001). The group × time interaction was significant (P < 0.001), after even considering separately subjects with normal muscle mass and low muscle mass at baseline (P < 0.05 and P = 0.005). Similar results were obtained for SMI. Considering only the subjects with normal SMI at baseline, subjects with MSRA questionnaire ≤ 30 showed 5.7 (95% CI 1.73–19.03) higher risk of exceeding the low muscle mass threshold.
Conclusion
In a population of community-dwelling elderly men and women, MSRA score of 30 is predictive of a steeper decline in ASMM and SMI and of a higher risk of exceeding the low muscle mass EWGSOP threshold.
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Acknowledgements
The authors' responsibilities were as follows—AR,SU,SG,MEG,MZ: analysis and interpretation of data and preparation of manuscript, AR,FF,MZ: study concept and design, SU,SG,NN,EZ,GM,FF,VM: acquisition of subjects, collection of data.
Funding
This work was supported by grants from MIUR COFIN 2003 n2003069951_002 and MIUR project 2009KENS9K-002.
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The study was approved by the Ethical Committee of Verona University (progressive number CE 567 approved June 28th, 1997).
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All the participants gave their consent to participate in the study.
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Rossi, A.P., Urbani, S., Gattazzo, S. et al. The Mini Sarcopenia Risk Assessment (MSRA) Questionnaire score as a predictor of skeletal muscle mass loss. Aging Clin Exp Res 33, 2593–2597 (2021). https://doi.org/10.1007/s40520-020-01763-1
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DOI: https://doi.org/10.1007/s40520-020-01763-1