Skip to main content

Advertisement

Log in

Aging and brown adipose tissue activity decline in human: does the brain extinguish the fire?

  • Point of View
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Smorlesi A, Frontini A, Giordano A et al (2012) The adipose organ: white-brown adipocyte plasticity and metabolic inflammation. Obes Rev 13(Suppl 2):83–96. doi:10.1111/j.1467-789X.2012.01039.x

    Article  CAS  PubMed  Google Scholar 

  2. van MarkenLichtenbelt WD, Vanhommerig JW, Smulders NM et al (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500–1508. doi:10.1056/NEJMoa0808718

    Article  Google Scholar 

  3. Enerback S (2010) Human brown adipose tissue. Cell Metab 11:248–252. doi:10.1016/j.cmet.2010.03.008

    Article  PubMed  Google Scholar 

  4. Lee P, Greenfield JR (2015) Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans. Mol Cell Endocrinol 418:184–190. doi:10.1016/j.mce.2015.05.025

    Article  CAS  PubMed  Google Scholar 

  5. Graja A, Schulz TJ (2015) Mechanisms of aging-related impairment of brown adipocyte development and function. Gerontology 61:211–217. doi:10.1159/000366557

    Article  PubMed  Google Scholar 

  6. Rogers NH (2015) Brown adipose tissue during puberty and with aging. Ann Med 47:142–149. doi:10.3109/07853890.2014.914807

    Article  CAS  PubMed  Google Scholar 

  7. Elsen M, Raschke S, Eckel J (2014) Browning of white fat: does irisin play a role in humans? J Endocrinol 222:R25–R38. doi:10.1530/JOE-14-0189

    Article  CAS  PubMed  Google Scholar 

  8. Wallace DC, Fan W, Procaccio V (2010) Mitochondrial energetics and therapeutics. Ann Rev Pathol 5:297–348. doi:10.1146/annurev.pathol.4.110807.092314

    Article  CAS  Google Scholar 

  9. Kindred JH, Tuulari JJ, Simon S et al (2016) Brown adipose and central nervous system glucose uptake is lower during cold exposure in older compared to young men: a preliminary PET study. Aging Clin Exp Res. doi:10.1007/s40520-015-0521-2 (Epub ahead of print)

  10. Yoneshiro T, Ogawa T, Okamoto N et al (2013) Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obes 37:993–998. doi:10.1038/ijo.2012.161

    Article  CAS  Google Scholar 

  11. Kuji I, Imabayashi E, Minagawa A et al (2008) Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma. Ann Nucl Med 22:231–235. doi:10.1007/s12149-007-0096-x

    Article  PubMed  Google Scholar 

  12. Mullur R, Liu YY, Brent GA (2014) Thyroid hormone regulation of metabolism. Physiol Rev 94:355–382. doi:10.1152/physrev.00030.2013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Orava J, Nummenmaa L, Noponen T et al (2014) Brown adipose tissue function is accompanied by cerebral activation in lean but not in obese humans. J Cereb Blood Flow Metab 34:1018–1023. doi:10.1038/jcbfm.2014.50

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Grover SA, Kaouache M, Rempel P et al (2015) Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study. Lancet Diabetes Endocrinol 3:114–122. doi:10.1016/S2213-8587(14)70229-3

    Article  PubMed  Google Scholar 

  15. Laimer M, Melmer A, Lamina C et al (2015) Telomere length increase after weight loss induced by bariatric surgery: results from a 10 years prospective study. Int J Obes. doi:10.1038/ijo.2015.238 (Epub ahead of print)

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marco Rossato.

Ethics declarations

Conflict of interest

The author declares that he has no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rossato, M. Aging and brown adipose tissue activity decline in human: does the brain extinguish the fire?. Aging Clin Exp Res 28, 579–581 (2016). https://doi.org/10.1007/s40520-016-0572-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40520-016-0572-z

Keywords

Navigation