References
Smorlesi A, Frontini A, Giordano A et al (2012) The adipose organ: white-brown adipocyte plasticity and metabolic inflammation. Obes Rev 13(Suppl 2):83–96. doi:10.1111/j.1467-789X.2012.01039.x
van MarkenLichtenbelt WD, Vanhommerig JW, Smulders NM et al (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500–1508. doi:10.1056/NEJMoa0808718
Enerback S (2010) Human brown adipose tissue. Cell Metab 11:248–252. doi:10.1016/j.cmet.2010.03.008
Lee P, Greenfield JR (2015) Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans. Mol Cell Endocrinol 418:184–190. doi:10.1016/j.mce.2015.05.025
Graja A, Schulz TJ (2015) Mechanisms of aging-related impairment of brown adipocyte development and function. Gerontology 61:211–217. doi:10.1159/000366557
Rogers NH (2015) Brown adipose tissue during puberty and with aging. Ann Med 47:142–149. doi:10.3109/07853890.2014.914807
Elsen M, Raschke S, Eckel J (2014) Browning of white fat: does irisin play a role in humans? J Endocrinol 222:R25–R38. doi:10.1530/JOE-14-0189
Wallace DC, Fan W, Procaccio V (2010) Mitochondrial energetics and therapeutics. Ann Rev Pathol 5:297–348. doi:10.1146/annurev.pathol.4.110807.092314
Kindred JH, Tuulari JJ, Simon S et al (2016) Brown adipose and central nervous system glucose uptake is lower during cold exposure in older compared to young men: a preliminary PET study. Aging Clin Exp Res. doi:10.1007/s40520-015-0521-2 (Epub ahead of print)
Yoneshiro T, Ogawa T, Okamoto N et al (2013) Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obes 37:993–998. doi:10.1038/ijo.2012.161
Kuji I, Imabayashi E, Minagawa A et al (2008) Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma. Ann Nucl Med 22:231–235. doi:10.1007/s12149-007-0096-x
Mullur R, Liu YY, Brent GA (2014) Thyroid hormone regulation of metabolism. Physiol Rev 94:355–382. doi:10.1152/physrev.00030.2013
Orava J, Nummenmaa L, Noponen T et al (2014) Brown adipose tissue function is accompanied by cerebral activation in lean but not in obese humans. J Cereb Blood Flow Metab 34:1018–1023. doi:10.1038/jcbfm.2014.50
Grover SA, Kaouache M, Rempel P et al (2015) Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study. Lancet Diabetes Endocrinol 3:114–122. doi:10.1016/S2213-8587(14)70229-3
Laimer M, Melmer A, Lamina C et al (2015) Telomere length increase after weight loss induced by bariatric surgery: results from a 10 years prospective study. Int J Obes. doi:10.1038/ijo.2015.238 (Epub ahead of print)
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Rossato, M. Aging and brown adipose tissue activity decline in human: does the brain extinguish the fire?. Aging Clin Exp Res 28, 579–581 (2016). https://doi.org/10.1007/s40520-016-0572-z
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DOI: https://doi.org/10.1007/s40520-016-0572-z