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Comparison of motor performance of upper and lower extremities in dual-task tests in patients with mild Alzheimer’s dementia

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Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

Background

Alzheimer’s dementia (AD) is a progressive disease that threatens the self-care and quality of life of elderly people. Early diagnosis and early treatment are crucial.

Aim

To examine the difference in executive function of patients with AD by analyzing their performance in gait analysis (Vicon MX system) and a trial making test (TMT) while counting forward or backward.

Methods

Ten elderly persons who had been diagnosed by neurological specialists with mild AD were selected as study participants. Of these patients, 2 were men and 8 were women, and the average age was 74.0 ± 8.6 years. An additional group of 10 elderly persons without AD and matched according to age and sex constituted a control group.

Results

The average Mini-Mental State Examination score was 17.7 ± 4.1, and the average clinical dementia rating scale score was 0.8 ± 0.3. We found that backward counting of 3 digits during gait performance in mild AD patients elicited substantial changes in velocity, cadence, coefficient of variation of the stride length, and stride time compared with those of the control group. Regarding upper extremity performance, all TMT tasks were highly sensitive in revealing differences in reaction time between the mild AD group and the control group.

Discussion

Dual-task challenges for examining gait parameters and TMT performance can reveal obvious impairment of executive motor function in patients with very mild AD.

Conclusion

Dual-task motor tests of the upper extremities can be used as screening tools for detecting AD at an early stage.

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Acknowledgments

This project was supported by research funding from the National Science Council of Taiwan, R. O. C. (NSC96-2314-B-182S-046-MY3).

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, 5, Fu-Hsin St., Kwei-Shan, Tao-Yuan, 333, Taiwan, Republic of China

    Yin-Chou Lin & Alice M. K. Wong

  2. Department of Neurology and Dementia Center, Chang Gung Memorial Hospital, 5, Fu-Hsin St., Kwei-Shan, Tao-Yuan, 333, Taiwan, Republic of China

    Wen-Chuin Hsu

  3. School of Medicine, Chang Gung University, 5, Fu-Hsin St., Kwei-Shan, Tao-Yuan, 333, Taiwan, Republic of China

    Wen-Chuin Hsu, Katie Pei-Hsuan Wu & Alice M. K. Wong

  4. Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, 5, Fu-Hsin St., Kwei-Shan, Tao-Yuan, 333, Taiwan, Republic of China

    Chih-Kuan Wu & Katie Pei-Hsuan Wu

  5. Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taipei, 5, Fu-Hsin St., Kwei-Shan, Tao-Yuan, 333, Taiwan, Republic of China

    Wei-Han Chang

Authors
  1. Yin-Chou Lin
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  2. Wen-Chuin Hsu
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  3. Chih-Kuan Wu
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  4. Wei-Han Chang
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  5. Katie Pei-Hsuan Wu
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  6. Alice M. K. Wong
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Corresponding author

Correspondence to Alice M. K. Wong.

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The authors declare there is no conflict of interest.

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The authors’ declare that they have no violation of human rights.

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Lin, YC., Hsu, WC., Wu, CK. et al. Comparison of motor performance of upper and lower extremities in dual-task tests in patients with mild Alzheimer’s dementia. Aging Clin Exp Res 28, 491–496 (2016). https://doi.org/10.1007/s40520-015-0441-1

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  • DOI: https://doi.org/10.1007/s40520-015-0441-1

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