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Functional interrelationship of brain aging and delirium

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Abstract

Theories on the development of delirium are complementary rather than competing and they may relate to each other. Here, we highlight that similar alterations in functional brain connectivity underlie both the observed age-related deficits and episodes of delirium. The default mode network (DMN) is a group of brain regions showing a greater level of activity at rest than during attention-based tasks. These regions include the posteromedial–anteromedial cortices and temporoparietal junctions. Evidence suggests that awareness is subserved through higher order neurons associated with the DMN. By using functional MRI disruption of DMN, connectivity and weaker task-induced deactivations of these regions are observed both in age-related cognitive impairment and during episodes of delirium. We can assume that an acute up-regulation of inhibitory tone within the brain acts to further disrupt network connectivity in vulnerable patients, who are predisposed by a reduced baseline connectivity, and triggers the delirium.

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The author declares that he has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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  1. Geriatrics Division, Ospedale di Circolo e Fondazione Macchi, 21100, Varese, Italy

    Piero Rapazzini

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  1. Piero Rapazzini
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Correspondence to Piero Rapazzini.

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Rapazzini, P. Functional interrelationship of brain aging and delirium. Aging Clin Exp Res 28, 161–164 (2016). https://doi.org/10.1007/s40520-015-0379-3

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  • DOI: https://doi.org/10.1007/s40520-015-0379-3

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