Abstract
Systemic lupus erythematosus (SLE) is a multisystemic disease which potentially involves various organs including the skin, joints, kidneys, liver, hematopoetic system, and serous membranes. It is rarely seen in elderly males. The most common cardiovascular involvement type is pericarditis. Anti-Ro antibodies may be associated with neonatal lupus which causes heart blocks. Recent literature indicates that anti-Ro antibodies may be associated with various rhythm and conduction disturbances in the adulthood. The most common finding associated with anti-Ro antibodies is prolonged corrected QT (QTc) interval. Herein, we present an elderly male patient with anti-Ro-positive SLE associated with prolonged QTc interval and AV blocks that significantly improved after corticosteroid treatment.
References
Petri M, Orbai AM, Alarcon GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sanchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG Jr, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G Jr, Magder LS (2012) Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64(8):2677–2686. doi:10.1002/art.34473
Bourre-Tessier J, Clarke AE, Huynh T, Bernatsky S, Joseph L, Belisle P, Pineau CA (2011) Prolonged corrected QT interval in anti-Ro/SSA-positive adults with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 63(7):1031–1037. doi:10.1002/acr.20470
Lazzerini PE, Capecchi PL, Acampa M, Morozzi G, Bellisai F, Bacarelli MR, Dragoni S, Fineschi I, Simpatico A, Galeazzi M, Laghi-Pasini F (2011) Anti-Ro/SSA-associated corrected QT interval prolongation in adults: the role of antibody level and specificity. Arthritis Care Res (Hoboken) 63(10):1463–1470. doi:10.1002/acr.20540
Sung MJ, Park SH, Kim SK, Lee YS, Park CY, Choe JY (2011) Complete atrioventricular block in adult Sjogren’s syndrome with anti-Ro autoantibody. Korean J Intern Med 26(2):213–215. doi:10.3904/kjim.2011.26.2.213
Lazzerini PE, Capecchi PL, Laghi-Pasini F (2010) Anti-Ro/SSA antibodies and cardiac arrhythmias in the adult: facts and hypotheses. Scand J Immunol 72(3):213–222. doi:10.1111/j.1365-3083.2010.02428.x
Karnabi E, Boutjdir M (2010) Role of calcium channels in congenital heart block. Scand J Immunol 72(3):226–234. doi:10.1111/j.1365-3083.2010.02439.x
Santos-Pardo I, Martinez-Morillo M, Villuendas R, Bayes-Genis A (2013) Anti-Ro antibodies and reversible atrioventricular block. N Engl J Med 368(24):2335–2337. doi:10.1056/NEJMc1300484
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Saribayev, M., Tufan, F., Oz, F. et al. Corticosteroid treatment normalizes QTc prolongation and improves heart block in an elderly patient with anti-Ro-positive systemic lupus erythematosus. Aging Clin Exp Res 26, 337–339 (2014). https://doi.org/10.1007/s40520-013-0168-9
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DOI: https://doi.org/10.1007/s40520-013-0168-9