Skip to main content

Advertisement

SpringerLink
Log in

Alcohol ingestion symptoms after sleeve gastrectomy: intoxication or drunkenness? A prospective study from a Bariatric Centre of Excellence

  • Original Article
  • Published:
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Purpose

The aim of this original research is to evaluate the effect of SG on alcohol intake symptoms, blood alcohol content (BAC), and alcohol metabolite levels.

Methods

At 0–6–12 months after SG, BAC of patients was measured at 0, 15, 30, and 60 min, and then every 30 min, and urinary metabolite (ethanol and acetaldehyde) levels were measured 2 h after consuming a standard red wine drink. Symptoms perceived by patients were evaluated using symptom alcoholization post-obesity surgery scores.

Results

Thirty obese patients (12 men/18 women; mean body mass index, 44 ± 4 kg/m2) who underwent SG were enrolled in this study. At 12 months after SG, no alcohol use disorder was observed and BAC tended to peak after 15 min, with alcohol intoxication symptoms (nausea/vomiting, flushing, and diaphoresis), and return to zero after 90 min of wine intake. Ethanol and acetaldehyde levels were significantly different at 12 months compared with the levels at time 0 (p < 0.05).

Conclusions

Following SG, patients exhibit a high BAC at 15 min after moderate alcohol consumption accompanied with increased metabolite excretion and intoxication symptoms.

Level of evidence

Level III obtained from well-designed cohort analytic study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Arroyo-Johnson C, Mincey KD (2016) Obesity epidemiology worldwide. Gastroenterol Clin N Am 45(4):571–579. https://doi.org/10.1016/j.gtc.2016.07.012

    Article  Google Scholar 

  2. Schauer PR, Bhatt DL, Kirwan JP, STAMPEDE Investigators et al (2017) Bariatric surgery versus intensive medical therapy for diabetes—5-year outcomes. N Engl J Med 376(7):641–651. https://doi.org/10.1056/nejmoa1600869

    Article  PubMed  PubMed Central  Google Scholar 

  3. Bariatric surgery improves quality of life and results in more weight loss than intensive medical therapy. Am Fam Physician 2017;95(12):805

  4. Angrisani L, Santonicola A, Iovino P et al (2018) IFSO Worldwide Survey 2016: primary, endoluminal, and revisional procedures. Obes Surg 28(12):3783–3794. https://doi.org/10.1007/s11695-018-3450-2

    Article  PubMed  Google Scholar 

  5. Peterli R, Steinert RE, Woelnerhanssen B et al (2012) Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obes Surg 22(5):740–748. https://doi.org/10.1007/s11695-012-0622-3

    Article  PubMed  PubMed Central  Google Scholar 

  6. Pournaras DJ (2009) le Roux CW (2009) Obesity, gut hormones, and bariatric surgery. World J Surg 33(10):1983–1988. https://doi.org/10.1007/s00268-009-0080-9

    Article  PubMed  Google Scholar 

  7. Shoar S, Naderan M, Shoar N et al (2019) Alteration pattern of taste perception after bariatric surgery: a systematic review of four taste domains. Obes Surg. https://doi.org/10.1007/s11695-019-03730-w

    Article  PubMed  Google Scholar 

  8. Ivezaj V, Benoit SC, Davis J et al (2019) Changes in alcohol use after metabolic and bariatric surgery: predictors and mechanisms. Curr Psychiatry Rep 21(9):85. https://doi.org/10.1007/s11920-019-1070-8

    Article  PubMed  PubMed Central  Google Scholar 

  9. Nance K, Acevedo MB, Pepino MY (2019) Changes in taste function and ingestive behavior following bariatric surgery. Appetite. https://doi.org/10.1016/j.appet.2019.104423

    Article  PubMed  Google Scholar 

  10. King WC, Chen JY, Mitchell JE et al (2012) Prevalence of alcohol use disorders before and after bariatricsurgery. JAMA 307(23):2516–2525. https://doi.org/10.1001/jama.2012.6147

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Wee CC, Mukamal KJ, Huskey KW et al (2014) High-risk alcohol use after weight loss surgery. Surg Obes Relat Dis 10(3):508–513. https://doi.org/10.1016/j.soard.2013.12.014

    Article  PubMed  PubMed Central  Google Scholar 

  12. Parikh M, Johnson JM, Ballem N, American Society for Metabolic and Bariatric Surgery Clinical Issues Committee (2016) ASMBS position statement on alcohol use before and after bariatric surgery. Surg Obes Relat Dis 12(2):225–230. https://doi.org/10.1016/j.soard.2015.10.085

    Article  PubMed  Google Scholar 

  13. Coluzzi I, Iossa A, Spinetti E et al (2018) Alcohol consumption after laparoscopic sleeve gastrectomy: 1-year results. Eat Weight Disord. https://doi.org/10.1007/s40519-018-0486-1. (Epub ahead of print)

    Article  PubMed  Google Scholar 

  14. Ibrahim N, Alameddine M, Brennan J et al (2019) New onset alcohol use disorder following bariatric surgery. Surg Endosc 33(8):2521–2530. https://doi.org/10.1007/s00464-018-6545-x. (Epub 2018 Oct 22)

    Article  PubMed  Google Scholar 

  15. Maluenda F, Csendes A, De Aretxabala X et al (2010) Alcohol absorption modification after a laparoscopic sleeve gastrectomy due to obesity. Obes Surg 20(6):744–748. https://doi.org/10.1007/s11695-010-0136-9

    Article  PubMed  Google Scholar 

  16. Changchien EM, Woodard GA, Hernandez-Boussard T, Morton JM (2012) Normal alcohol metabolism after gastric banding and sleeve gastrectomy: a case-crossover trial. J Am Coll Surg 215(4):475–479. https://doi.org/10.1016/j.jamcollsurg.2012.06.008

    Article  PubMed  Google Scholar 

  17. Gallo AS, Berducci MA, Nijhawan S et al (2015) Alcohol metabolism is not affected by sleeve gastrectomy. Surg Endosc 29(5):1088–1093. https://doi.org/10.1007/s00464-014-3790

    Article  CAS  PubMed  Google Scholar 

  18. Acevedo MB, Eagon JC, Bartholow BD et al (2018) Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis 14(3):277–283. https://doi.org/10.1016/j.soard.2017.11.010. (Epub 2017 Nov 10)

    Article  PubMed  Google Scholar 

  19. American Diabetes Association (2018) Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2018. Diabetes Care 41(Supplement 1):S13–S27. https://doi.org/10.2337/dc18-S002

    Article  Google Scholar 

  20. Thomas F, Babor John C, Higgins-Biddle John B et al (2001) The alcohol use disorders identification test (AUDIT) guidelines for use in primary care World Health Organization Department of mental health and substance dependence WHO/MSD/MSB/01.6. https://doi.org/10.1080/00952990.2018.1456545

  21. Steffen KJ, Engel SG, Wonderlich JA et al (2015) Alcohol and other addictive disorders following bariatric surgery: prevalence, risk factors and possible etiologies. Eur Eat Disord Rev 23(6):442–450. https://doi.org/10.1002/erv.2399

    Article  PubMed  Google Scholar 

  22. Blackburn AN, Hajnal A (2017) Leggio L The gut in the brain: the effects of bariatric surgery on alcohol consumption. Addict Biol 22(6):1540–1553. https://doi.org/10.1111/adb.12436. (Epub 2016 Aug 31)

    Article  PubMed  Google Scholar 

  23. Azam H, Shahrestani S, Phan K (2018) Alcohol use disorders before and after bariatric surgery: a systematic review and meta-analysis. Ann Transl Med 6(8):148. https://doi.org/10.21037/atm.2018.03.16

    Article  PubMed  PubMed Central  Google Scholar 

  24. Klockhoff H, Naeslund I, Jones AW (2002) Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery. Br J Clin Pharmacol 54:587–591. https://doi.org/10.1046/j.1365-2125.2002.01698.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Hagedorn J, Encarnacion B, Brat G et al (2007) Does gastric bypass alter alcohol metabolism? Surg Obes Relat Dis 3:543–548. https://doi.org/10.1016/j.soard.2007.07.003

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of General Surgery and Bariatric Centre of Excellence, Department of Medical-Surgical Sciences and Biotechnologies, University of Rome “La Sapienza”, Rome, Italy

    Angelo Iossa, Maria Chiara Ciccioriccio, Anna Guida & Gianfranco Silecchia

  2. Biochemistry, Researcher of Department of Medicine and Pharmacy, University of Rome “La Sapienza”, Rome, Italy

    Chiara Zerbinati

  3. Head of Clinical Pathology Department, Santa Maria Goretti Hospital, Latina, Italy

    Liliana Di Giacomo

Authors
  1. Angelo Iossa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Chiara Ciccioriccio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chiara Zerbinati
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anna Guida
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Liliana Di Giacomo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Gianfranco Silecchia
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Angelo Iossa.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The present study was approved by the ethical committee of ASL-Roma 2 (protocol number 64170/2016; June 30, 2016).

Informed consent

All the patients signed a specific informed consent.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Iossa, A., Ciccioriccio, M.C., Zerbinati, C. et al. Alcohol ingestion symptoms after sleeve gastrectomy: intoxication or drunkenness? A prospective study from a Bariatric Centre of Excellence. Eat Weight Disord 25, 1719–1725 (2020). https://doi.org/10.1007/s40519-019-00813-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40519-019-00813-6

Keywords

Search

Navigation