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The interaction between dietary inflammatory index and 6 P21 rs2010963 gene variants in metabolic syndrome

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Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Background

The Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and angiogenesis, promotes vascular and capillary permeability and also is involved in inflammation. VEGF gene has been suggested to play an important role in the pathogenesis of metabolic syndrome. The aim of this study was to investigate the association between inflammatory potential of a diet and + 405 VEGF C/G (rs2010963) polymorphism and metabolic components in patients with metabolic syndrome.

Methods

One hundred fifty patients with metabolic syndrome and fifty healthy individuals were enrolled. A semi-quantitative food-frequency questionnaire (FFQ) was used for dietary assessments and dietary inflammatory index (DII) calculation. Biochemical assays including fasting serum glucose (FSG), serum insulin, matrix metalloproteinase-3 (MMP-3), liver enzymes and lipid profile were measured. Polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP) method was used for the determination of gene polymorphism.

Results

In the current study, patients with metabolic syndrome had higher serum low density lipoprotein (LDL) and lower high density lipoprotein (HDL) concentrations compared with healthy subjects. Patients with lower DII quartiles and lower inflammatory potential of the diet had lower waist to hip ratio (WHR) and lower diastolic blood pressure (DBP) compared with patients in higher DII quartiles (P < 0.05). Moreover, patients and healthy subjects in second quartile of DII had significantly higher aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations compared with subjects in the first quartile; also healthy subjects in third quartile had significantly higher triglyceride (TG) and total cholesterol (TC) concentrations compared with subjects in second quartile (P < 0.05). Among different genotypes of 6 P21 rs2010963 gene variants in patients with metabolic syndrome, CC genotype indicated the highest DII compared with other genotypes (P < 0.05).

Conclusion

The current study revealed the association between DII and metabolic risk factors of metabolic syndrome.

Level of evidence

Level III, case-control analytic study.

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Abbreviations

ANOVA:

Analysis of variance

CAD:

Coronary artery disease

CVD:

Cardiovascular disease

MetS:

Metabolic syndrome

HDL:

High-density lipoprotein cholesterol

LDL:

Low-density lipoprotein cholesterol

TC:

Total cholesterol

TNF-α:

Tumor necrosis factor-α

DII:

Dietary inflammatory index

CRP:

C-reactive protein

IL:

Interleukin

FSG:

Fasting serum glucose

MMP-3:

Matrix metalloproteinase-3

PCR-RFLP:

Polymerase chain reaction-restriction fragments length polymorphism

TLGS:

Tehran lipid and glucose study

VEGF:

Vascular endothelial growth factor

NCEP-ATP III:

National Cholesterol Education Program’s Adult Treatment Panel III

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Acknowledgements

We thank all of the study participants.

Funding

The work has been granted by a grant from Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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Authors and Affiliations

  1. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mahdieh Abbasalizad Farhangi

  2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mahdieh Abbasalizad Farhangi

  3. Research Center for Evidence Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Mahdi Vajdi

  4. Tabriz Health Services Management Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Leila Nikniaz

  5. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Zeinab Nikniaz

Authors
  1. Mahdieh Abbasalizad Farhangi
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  2. Mahdi Vajdi
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  3. Leila Nikniaz
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  4. Zeinab Nikniaz
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Contributions

All authors read and approved the final version of the manuscript. MAF designed the idea of the project, performed the statistical analysis, wrote the first draft of the manuscript and revised it, MV was involved in manuscript revision and LN and ZN both were involved in the data collection, laboratory assessments and manuscript drafting.

Corresponding author

Correspondence to Mahdieh Abbasalizad Farhangi.

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Ethical approval

The study protocol has been approved by the ethics committee of the Tabriz University of Medical Sciences.

Informed consent

All of the participants signed and approved a written informed consent before participation in the study.

Conflict of interest

The authors declare that there is no conflict of interest.

Novelty statement

This work is the first study evaluates the gene-nutrient interaction from the perspective of DII-gene interactions.

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Abbasalizad Farhangi, M., Vajdi, M., Nikniaz, L. et al. The interaction between dietary inflammatory index and 6 P21 rs2010963 gene variants in metabolic syndrome. Eat Weight Disord 25, 1049–1060 (2020). https://doi.org/10.1007/s40519-019-00729-1

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  • DOI: https://doi.org/10.1007/s40519-019-00729-1

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