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Comparison of visceral, general and central obesity indices in the prediction of metabolic syndrome in maintenance hemodialysis patients

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Abstract

Purpose

We aimed to compare the predictive ability of the anthropometric indices reflecting general, central and visceral obesity for identification of metabolic syndrome (MetS) in maintenance hemodialysis (MHD) patients.

Methods

A multicenter, cross-sectional study that consisted of 1603 adult MHD patients (54.6 ± 16 years) was conducted in Guizhou Province, Southwest China. Eight anthropometric obesity indexes including body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), conicity index (Ci) and visceral adiposity index (VAI), lipid accumulation product (LAP), a body shape index (ABSI) and body roundness index (BRI) were recorded. MetS was defined based on the criteria of the International Diabetes Federation. Participants were categorized into four groups according to quartiles of different obesity indices. Binary logistic regression analyses were used to evaluate the associations between the eight obesity parameters and MetS. Receiver operator curve (ROC) analyses were used to identify the best predictor of MetS.

Results

The eight anthropometric obesity indexes were independently associated with MetS risk, even after adjustment for age, sex, educational status and history of smoking. The ROC analysis revealed that all the eight obesity indices included in the study were able to discriminate MetS [all area under the ROC curves (AUCs) > 0.6, P < 0.05]. LAP showed the highest AUC and according to the maximum Youden indexes, the cut off values for men and women were 27.29 and 36.45, respectively. The AUCs of LAP, VAI, ABSI, BRI, WC, WHtR, Ci and BMI were 0.88, 0.87, 0.60, 0.78, 0.79, 0.78, 0.69 and 0.76 for men, and 0.87, 0.85, 0.65, 0.79, 0.81, 0.79, 0.73 and 0.76 for women, respectively. There was no significant difference in the AUC value between LAP and VAI, BRI/WHtR and BMI in men and between BRI/WHtR and BMI in women. The AUC value for WHtR was equal to that for BRI in identifying MetS.

Conclusions

Visceral obesity marker LAP followed by VAI was the most effective predictor of MetS while ABSI followed by CI was the weakest indicator for the screening of MetS in MHD patients. BRI could be an alternative obesity measure to WHtR in assessment of MetS. LAP may be a simple and useful screening tool to identify individuals at high risk of MetS particularly in middle-aged and elderly Chinese MHD patients.

Level of evidence

Level V, descriptive study.

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Acknowledgements

This study was supported by the following Science Foundation: (1) Qian Ke Co LH characters [2016]7151 from Guizhou science and technology plan project; (2) GZSYQN (2016)11.

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Author notes

  1. Chaomin Zhou and Lin Zhan contributed equally to this work.

Authors and Affiliations

  1. Renal Division, Department of Medicine, Guizhou Provincial People’ s Hospital, Guizhou Provincial Institute of Nephritic and Urinary Disease, Guiyang, 550002, Guizhou, China

    Chaomin Zhou, Jing Yuan, Xiaoya Tong, Yanzhe Peng & Yan Zha

  2. Blood Center of Guizhou Province, Guiyang, China

    Lin Zhan

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  1. Chaomin Zhou
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  2. Lin Zhan
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  3. Jing Yuan
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  6. Yan Zha
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Contributions

CZ and LZ contributed to the design, analysis, and interpretation of the data and drafted the manuscript; YZ provided guidance in the writing of this paper; JY, XT and YP contributed to the acquisition of the data.

Corresponding author

Correspondence to Yan Zha.

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We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.

Ethical statement

Ethics Committee of The People’ s Hospital of Guizhou province approved the study. This study was performed fulfilling the principles of Helsinki Declaration.

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Informed consent was obtained from all participants included in the study.

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Zhou, C., Zhan, L., Yuan, J. et al. Comparison of visceral, general and central obesity indices in the prediction of metabolic syndrome in maintenance hemodialysis patients. Eat Weight Disord 25, 727–734 (2020). https://doi.org/10.1007/s40519-019-00678-9

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  • DOI: https://doi.org/10.1007/s40519-019-00678-9

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