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Progress in Bioengineered Whole Tooth Research: from Bench to Dental Patient Chair

  • Orodental Regenerative Medicine (M Bartold, Section Editor)
  • Published:
Current Oral Health Reports Aims and scope Submit manuscript

Abstract

Significance

Tooth loss is a significant health issue that affects the physiological and social aspects of everyday life. Missing teeth impair simple tasks of chewing and speaking and can also contribute to reduced self-confidence. An emerging and exciting area of regenerative medicine-based dental research focuses on the formation of bioengineered whole tooth replacement therapies that can provide both the function and sensory responsiveness of natural teeth. This area of research aims to enhance the quality of dental and oral health for those suffering from tooth loss. Current approaches use a combination of dental progenitor cells, scaffolds and growth factors to create biologically based replacement teeth to serve as improved alternatives to currently used artificial dental prosthetics.

Purpose

This article is an overview of current progress, challenges, and future clinical applications of bioengineered whole teeth.

Conclusion

Recent accomplishments suggest that whole tooth bioengineering for human tooth replacement is indeed possible and, in fact, is the future of dentistry.

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Authors and Affiliations

  1. Department of Cell, Molecular, and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, M824, Boston, MA, 02111, USA

    Elizabeth E. Smith & Pamela C. Yelick

  2. Department of Orthodontics, Tufts University School of Dental Medicine, Boston, MA, USA

    Elizabeth E. Smith & Pamela C. Yelick

  3. Division of Craniofacial and Molecular Genetics, Department of Orthodontics, Tufts University School of Dental Medicine, Boston, MA, USA

    Pamela C. Yelick

  4. Department of Biomedical Engineering, Tufts University, Medford, MA, USA

    Pamela C. Yelick

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  1. Elizabeth E. Smith
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Correspondence to Pamela C. Yelick.

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Elizabeth E. Smith declares that she has no conflict of interest.

Pamela C. Yelick reports that she has two patents pending, one relevant to the field of study, and one that is not.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Orodental Regenerative Medicine

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Smith, E.E., Yelick, P.C. Progress in Bioengineered Whole Tooth Research: from Bench to Dental Patient Chair. Curr Oral Health Rep 3, 302–308 (2016). https://doi.org/10.1007/s40496-016-0110-2

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