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67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG

  • Food Factors: Molecular Targets, mechanisms, pharmacology and in vivo efficacy (D-X Hou, Section Editor)
  • Published:
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Abstract

Purpose of Review

Green tea is one of the most consumed beverages in the world. Through in vivo models and clinical trials, several studies have shown the beneficial effects of green tea. Epidemiological studies have revealed that green tea consumption is negatively correlated with the risk of cardiovascular diseases, stroke and cancer; however, little is known about the underlying molecular mechanisms.

Recent Findings

(−)-Epigallocatechin-3-O-gallate (EGCG) is one of the major bioactive compounds in green tea, and several studies emphasise its central role in the beneficial effects of green tea. It has been demonstrated that the 67-kDa laminin receptor, a non-integrin laminin receptor, mediates the beneficial effects of EGCG through cyclic guanosine monophosphate–dependent mechanisms.

Summary

In this review, we showed the role of 67LR as the sensor of the EGCG and its downstream cascade, and this review provides the recent findings in the mechanism of the beneficial effect of EGCG.

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Acknowledgments

We are deeply grateful to Mana Miyabe for Figure illustration.

Funding

This work was supported in part by JSPS KAKENHI, grant 22228002 and JP15H02448, to H. Tachibana. This work was also supported in part by a grant-in-aid for JSPS KAKENHI, grant JP15K18821, to M. Kumazoe.

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Authors and Affiliations

  1. Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan

    Motofumi Kumazoe, Yoshinori Fujimura & Hirofumi Tachibana

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  1. Motofumi Kumazoe
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  2. Yoshinori Fujimura
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  3. Hirofumi Tachibana
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Correspondence to Hirofumi Tachibana.

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Kumazoe, M., Fujimura, Y. & Tachibana, H. 67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG. Curr Pharmacol Rep 6, 280–285 (2020). https://doi.org/10.1007/s40495-020-00228-3

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