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Control of CNS Functions by RNA-Binding Proteins in Neurological Diseases

  • Neurogenesis and Disease (L Cai, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review summarizes recent studies on the molecular mechanisms of RNA-binding proteins (RBPs) that control neurological functions and pathogenesis in various neurodevelopmental and neurodegenerative diseases, including autism spectrum disorders, schizophrenia, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and spinocerebellar ataxia.

Recent Findings

RBPs are critical players that regulate every step of posttranscriptional modifications of gene expression. Recent genome-wide approaches revealed that many proteins associate with RNA, but do not contain any known RNA-binding motifs. Additionally, many causal and risk genes of neurodevelopmental and neurodegenerative diseases are RBPs. Development of high-throughput sequencing methods has mapped out the fingerprints of RBPs on transcripts and provided unprecedented potential to discover new mechanisms of neurological diseases. Insights into how RBPs modulate neural development are important for designing effective therapies for numerous neurodevelopmental and neurodegenerative diseases.

Summary

RBPs have diverse mechanisms for modulating RNA processing and, thereby, controlling neurogenesis. Understanding the role of disease-associated RBPs in neurogenesis is vital for developing novel treatments for neurological diseases.

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Funding

We thank Young Investigator Grant of NARSAD and Scientist Development Grant of American Heart Association for Yingwei Mao. This work is supported by NIH 1R21MH108983.

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  1. Yijing Zhou and Fengping Dong contributed equally to this work.

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  1. Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA

    Yijing Zhou, Fengping Dong & Yingwei Mao

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  1. Yijing Zhou
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Correspondence to Yingwei Mao.

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This article is part of the Topical Collection on Neurogenesis and Disease

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Zhou, Y., Dong, F. & Mao, Y. Control of CNS Functions by RNA-Binding Proteins in Neurological Diseases. Curr Pharmacol Rep 4, 301–313 (2018). https://doi.org/10.1007/s40495-018-0140-7

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