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The real-time intraoperative guidance of the new HIFU Focal-One® platform allows to minimize the perioperative adverse events in salvage setting

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Abstract

Purpose

To assess the use of the new Focal-One® HIFU platform in salvage setting to evaluate the occurrence of postoperative complications.

Methods

Patients who underwent salvage HIFU (sHIFU) with Focal-One® platform were enrolled prospectively (Candiolo cancer institute—FPO IRCCS; registry number: 258/2018). Perioperative and postoperative outcomes (in terms of oncological and functional ones) were recorded during the first year of follow-up. In particular postoperative complications were classified according to Clavien–Dindo system.

Results

20 patients were enrolled. No grade 3 complications were recorded. Referring to grade 2 complications, eight patients reported urgency after 3 months of follow-up, and in 4 cases, a low urinary tract infection occurred. Evaluating the impact of sHIFU on patients’ sexual potency, micturition and quality of life, no significant deterioration was recorded during the follow-up as proven using the ANOVA analysis for repeated measurements. Only two patient had a biochemical failure after 12 months of follow-up.

Conclusions

The real-time intraoperative guidance with Focal-One® platform, allows a continuous monitoring and tailoring of the treatment, with a minimization of the adverse events even in a salvage setting.

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Availability of data and materials

Data are available under request.

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Funding

The author(s) did not receive specific funding for this work.

Author information

Author notes

  1. Cristian Fiori and Francesco Porpiglia contributed equally to senior authorship

Authors and Affiliations

  1. Department of Surgery, Candiolo Cancer Institute, FPO-IRCCS, Strada Provinciale 142, km 3,95, 10060, Candiolo, Turin, Italy

    Enrico Checcucci & Diletta Garrou

  2. Uro-Technology and SoMe Working Group of the Young Academic Urologists (YAU) Working Party of the European Association of Urology (EAU), Arnhem, The Netherlands

    Enrico Checcucci

  3. Department of Oncology, Division of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy

    Enrico Checcucci, Stefano De Luca, Federico Piramide, Diletta Garrou, Daniele Amparore, Paolo Verri, Gabriele Volpi, Matteo Manfredi, Cristian Fiori & Francesco Porpiglia

  4. Multidisciplinary Outpatient Oncology Clinic, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy

    Alessandra Mosca

  5. Division of Radiation Therapy, Candiolo Cancer Institute, Candiolo, Turin, Italy

    Andrea Galla & Gaetano Belli

  6. Department of Radiology, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy

    Filippo Russo

  7. Interdisciplinary Group for Translational Research and Clinical Trials (GIRT-Uro), Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy

    Pasquale Rescigno

  8. Department of Nuclear Medicine, Azienda USL Della Valle d’Aosta, Aosta, Italy

    Carlo Poti

Authors
  1. Enrico Checcucci
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  2. Stefano De Luca
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  3. Federico Piramide
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  4. Diletta Garrou
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  11. Daniele Amparore
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  16. Francesco Porpiglia
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Contributions

Concept and design: EC, SDL; acquisition of data: DG, DA; analysis and interpretation of data: FP, GV, PV; drafting of the manuscript: EC; critical revision: AM, GB, AG, PR, MM; technical or material support: FR, CP; statistical analysis: FP; supervision: CF, FP.

Corresponding author

Correspondence to Enrico Checcucci.

Ethics declarations

Conflict of interest

All authors have nothing to disclose.

Ethics approval

The study was approved by the local ethics committee (Candiolo cancer institute—FPO—IRCCS; registry number: 258/2018).

Consent to participate

Oral informed consent was obtained from all individual participants included in the study.

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The authors affirm that human research participants provided oral informed consent for publication.

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Supplementary Information

Below is the link to the electronic supplementary material.

40477_2021_594_MOESM1_ESM.jpg

Supplementary file1 (JPG 189 kb) Supplementary Figure 1: Focal-One platform description. With Focal-One platform the high-intensity ultrasounds are emitted by a robotic endorectal applicator with a Dynamic Focusing transducer. Moreover, aimed to improve the safety of the entire procedure, an infrared external movement detector is located at the level of patient’s iliac crest. The treatment screen allows to plan and execute the treatment, whilst the image screen allows to visualize the prostate and the target area three-dimensionally and to perform the elastic fusion between TRUS and mp-MRI images in case of focal treatment

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Checcucci, E., De Luca, S., Piramide, F. et al. The real-time intraoperative guidance of the new HIFU Focal-One® platform allows to minimize the perioperative adverse events in salvage setting. J Ultrasound 25, 225–232 (2022). https://doi.org/10.1007/s40477-021-00594-8

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  • DOI: https://doi.org/10.1007/s40477-021-00594-8

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