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Effect of CPP-ACP on Streptococcus mutans in saliva of high caries-risk preschool children: a randomized clinical trial

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European Archives of Paediatric Dentistry Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to assess the efficacy of CPP-ACP in reducing salivary S. mutans levels and compare its effect as a dentifrice to use of a fluoride dentifrice alone, or with the sequential use of a combination of both agents (fluoride, then CPP-ACP) in three groups of preschool children over a 6-month period.

Methods

This was a double-blinded clinical trial, the sample (n = 127, age 4.6 ± 0.47 years), with high caries risk, was randomized into three groups which applied different agents twice daily; fluoride toothpaste (500 ppm, n = 50), CPP-ACP (10% w/v, n = 38), and combination group (n = 39) applied fluoride, then CPP-ACP. S. mutans salivary levels were measured by GC Saliva-Check Mutans™.

Results

Within groups, a significant decrease in S. mutans-positive children (SMPC) occurred in fluoride and combination groups at 3-months, (P < 0.05), and in all groups at 6-months, (P < 0.05). The highest reduction in SMPC occurred in the CPP-ACP group, however, there were no significant differences in SMPC between groups at all study intervals, (P > 0.05).

Conclusion

Although all agents were effective, CPP-ACP showed the highest reduction in SMPC over 6-months.

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Acknowledgements

The authors would like to acknowledge the Deanship of Research, at Jordan University of Science and Technology, Irbid 22110, Jordan for funding this research (grant # 269-2015).

Funding

This project was funded by the Deanship of Research, at Jordan University of Science and Technology, Irbid 22110, Jordan (grant # 269-2015).

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Authors and Affiliations

  1. Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, PO Box 3030, Irbid, 22110, Jordan

    O. B. Al-Batayneh

  2. Department of Preventive Dentistry, Jordan University of Science and Technology, PO Box 3030, Irbid, 22110, Jordan

    S. A. Al-Rai

  3. Department of Public Health and Epidemiology, Faculty of Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid, 22110, Jordan

    Y. S. Khader

Authors
  1. O. B. Al-Batayneh
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  2. S. A. Al-Rai
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  3. Y. S. Khader
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Corresponding author

Correspondence to O. B. Al-Batayneh.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Ethical considerations

The study protocol was approved by the Institutional Review Board (IRB), Jordan University of Science and Technology, Irbid, Jordan (IRB # 269/2015). Proper permissions were obtained from the Ministry of Education, Jordan. Prior written consent explaining objectives of the study was obtained from parents/guardians for their children to participate. Trial registration: ClinicalTrials.gov Identifier: NCT03526315 ‘retrospectively registered’.

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Informed consent was obtained from all individual participants included in the study.

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Al-Batayneh, O.B., Al-Rai, S.A. & Khader, Y.S. Effect of CPP-ACP on Streptococcus mutans in saliva of high caries-risk preschool children: a randomized clinical trial. Eur Arch Paediatr Dent 21, 339–346 (2020). https://doi.org/10.1007/s40368-019-00490-0

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  • DOI: https://doi.org/10.1007/s40368-019-00490-0

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