Skip to main content
Log in

Prevention of Cardiovascular Diseases in Children and Adolescents

  • Review Article
  • Published:
High Blood Pressure & Cardiovascular Prevention Aims and scope Submit manuscript

Abstract

The atherosclerotic alterations that are the basis of cardiovascular diseases can start already in childhood. For this reason the prevention of cardiovascular diseases should be undertaken very early both in the general population and, in a targeted manner, in subjects at cardiovascular risk. Preventive strategies should include measures to encourage physical activity and correct eating habits and to reduce exposure to pollutants. The main actors responsible for carrying out these preventive interventions are the local and national political authorities. Moreover, particular attention should be paid to the first thousand days of life starting from conception, to prevent unfavorable epigenetic modifications. In addition to initiatives aimed at the general population, interventions should be planned by the medical community to assess the individual risk profile. The current obesity epidemic has in fact made it relatively frequent even among children and adolescents to find some cardiovascular risk factors known in adults such as arterial hypertension, dyslipidemia, glucose metabolism disorders and increased of uric acid values. The purpose of this review is to indicate lines of intervention for cardiovascular prevention in children and adolescents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. http://www.istat.it. centro diffusione dati.

  2. Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults: the Bogalusa Heart Study. N Engl J Med. 1998;338:1650–6.

    Article  CAS  PubMed  Google Scholar 

  3. Milei J, Ottaviani G, Lavezzi AM, Grana DR, Stella I, Matturri L. Perinatal and infant early atherosclerotic coronary lesions. Can J Cardiol. 2008;24:137–41.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Fuster V. Children are key to CVD prevention. NatRevCardiol. 2010;7:297–8.

    Google Scholar 

  5. Barker DJ. Fetal origins of coronary heart disease. BMJ. 1995;311:171–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Muth ND, Dietz WH, Magge SN, Johnson RK. Public policies to reduce sugary drink consumption in children and adolescents. Pediatrics. 2019;143(4):5.

    Article  Google Scholar 

  7. Lee M, Falbe J, Schillinger D, Basu S, McCulloch CE, Madsen KA. Sugar-sweetened beverage consumption 3 years after the Berkeley, California, sugar-sweetened beverage tax. Am J Public Health. 2019;109(4):637–9.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Bartelink NHM, Van Assema P, Kremers SPJ, Savelberg HHCM, Oosterhoff M, Willeboordse M, et al. One- and two-year effects of the healthy primary school of the future on children’s dietary and physical activity behaviours: a quasi-experimental study. Nutrients. 2019;11(3):689.

    Article  PubMed Central  Google Scholar 

  9. Marciniak A, Patro-Małysza J, Kimber-Trojnar Z, Marciniak B, Oleszczuk J, Leszczynska-Gorzelak B. Fetal programming of the metabolic syndrome. Taiwan J Obstet Gynecol. 2017;56:133–8.

    Article  PubMed  Google Scholar 

  10. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 2010;107(26):11971–5.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med. 2016;375(24):2369–79.

    Article  CAS  PubMed  Google Scholar 

  12. Korpela K, Zijlmans MA, Kuitunen M, Kukkonen K, Savilahti E, Salonen A, et al. Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use. Microbiome. 2017;5(1):26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kramer MS. “Breast is best”: the evidence. Early Hum Dev. 2010;86(11):729–32.

    Article  PubMed  Google Scholar 

  14. Melnik BC, John SM, Schmitz G. Milk is not just food but most likely a genetic transfection system activating mTORC1 signalling for postnatal growth. Nutr J. 2013;12:103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Victora CG, Bahl R, Barros AJ, França GV, Horton S, Krasevec J, et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet. 2016;10017:475–90.

    Article  Google Scholar 

  16. Genovesi S, Brambilla P, Giussani M, Galbiati S, Mastriani S, Pieruzzi F, et al. Insulin resistance, prehypertension, hypertension and blood pressure values in paediatric age. J Hypertens. 2012;30(2):327–35.

    Article  CAS  PubMed  Google Scholar 

  17. Viazzi F, Antolini L, Giussani M, Brambilla P, Galbiati S, Mastriani S, et al. Serum uric acid and blood pressure in children at cardiovascular risk. Pediatrics. 2013;132(1):e93–9.

    Article  PubMed  Google Scholar 

  18. http://www.who.int/mediacentre/factsheets/fs311/en/.

  19. http://www.osservatoriosullasalute.it/osservasalute/rapporto-osservasalute-2016.

  20. Valerio G, Maffeis C, Saggese G, Ambruzzi MA, Balsamo A, Bellone S, et al. Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics. Ital J Pediatr. 2018;44(1):88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Pieruzzi F, Antolini L, Salerno FR, Giussani M, Brambilla P, Galbiati S, et al. The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children. J Hypertens. 2015;33(6):1182–92.

    Article  CAS  PubMed  Google Scholar 

  22. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114:555–576.

  23. Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, CarrollAE, Daniels SR, et al; Subcommittee on Screening and Management of High Blood Pressure in Children. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Pediatrics. 2017;140(3):e20171904.

  24. Brady TM, Stefani-Glücksberg A, Simonetti GD. Management of high blood pressure in children: similarities and differences between US and European guidelines. Pediatr Nephrol. 2017.

  25. Genovesi S, Giussani M, Pieruzzi F, Vigorita F, Arcovio C, Cavuto S, et al. Results of blood pressure screening in a population of school-aged children in the province of Milan: role of overweight. J Hypertens. 2005;23(3):493–7.

    Article  CAS  PubMed  Google Scholar 

  26. Genovesi S, Antolini L, Giussani M, Brambilla P, Barbieri V, Galbiati S, et al. Hypertension, prehypertension, and transient elevated blood pressure in children: association with weight excess and waist circumference. Am J Hypertens. 2010;23(7):756–61.

    Article  PubMed  Google Scholar 

  27. Nadeau KJ, Anderson BJ, Berg EG, Chiang JL, Chou H, Copeland KC, et al. Youth-onset type 2 diabetes consensus report: current status. Challenges Prior Diabetes Care. 2016;39:1635–42.

    Article  Google Scholar 

  28. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31(Suppl 1):S55–60.

    Article  CAS  Google Scholar 

  29. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr. 2005;146(5):693–700.

    Article  PubMed  Google Scholar 

  30. May AL, Kuklina EV, Yoon PW. Prevalence of cardiovascular disease risk factors among US adolescents, 1999–2008. Pediatrics. 2012;129(6):1035–41.

    Article  PubMed  Google Scholar 

  31. Kao KT, Sabin MA. Type 2 diabetes mellitus in children and adolescents. Aust Fam Physician. 2016;45(6):401–6.

    PubMed  Google Scholar 

  32. Valerio G, Licenziati MR, Barbetti F, Blasetti A, Bruzzese M, Buono P, et al. Diabete tipo 2 e obesità pediatrica: rassegna a cura dei Gruppi di Studio Obesità Infantile e Diabete della Società Italiana di Endocrinologia e Diabetologia Pediatrica. Giornale italiano di diabetologia e metabolismo. 2017;37:213–30.

    Google Scholar 

  33. Maffeis C, Banzato C, Brambilla P, Cerutti F, Corciulo N, Cuccarolo G, et al. Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology. Insulin resistance is a risk factor for high blood pressure regardless of body size and fat distribution in obese children. Nutr Metab Cardiovasc Dis. 2010;20:266–273.

  34. Martino F, Puddu PE, Pannarale G, Colantoni C, Zanoni C, Martino E, et al. Arterial blood pressure and serum lipids in a population of children and adolescents from Southern Italy: The Calabrian Sierras Community Study (CSCS). Int J Cardiol. 2013;168:1108–14.

    Article  PubMed  Google Scholar 

  35. Kwiterovich PO Jr. Recognition and management of dyslipidemia in children and adolescents. J Clin Endocrinol Metab. 2008;93(11):4200–9.

    Article  CAS  PubMed  Google Scholar 

  36. Nguyen D, Kit B, Carroll M. Abnormal cholesterol among children and adolescents in the United States, 2011–2014. NCHS Data Brief. 2015;228:1–8.

    Google Scholar 

  37. Napoli C, Glass CK, Witztum JL, Deutsch R, D’Armiento FP, Palinski W. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: fate of Early Lesions in Children (FELIC) study. Lancet. 1999;354:1234–41.

    Article  CAS  PubMed  Google Scholar 

  38. Sjouke B, Kusters DM, Kindt I, Besseling J, Defesche JC, Sijbrands EJ, et al. Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype–phenotype relationship, and clinical outcome. Eur Heart J. 2015;36:560–5.

    Article  PubMed  Google Scholar 

  39. Akioyamen LE, Genest J, Shan SD, Reel RL, Albaum JM, Chu A, et al. Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis. BMJ Open. 2017;7:e016461.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Webber LS, Srinivasan SR, Wattigney WA, Berenson GS. Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study. Am J Epidemiol. 1991;133:884–98.

    Article  CAS  PubMed  Google Scholar 

  41. Smith AJ, Turner EL, Kinra S. Universal cholesterol screening in childhood: a systematic review. AcadPediatr. 2016;16:716–25.

    Google Scholar 

  42. Orlando A, Cazzaniga E, Giussani M, Palestini P, Genovesi S. Hypertension in children: role of obesity, simple carbohydrates, and uric acid. Front Public Health. 2018;6:129.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Simonetta Genovesi.

Ethics declarations

Conflict of Interest

There are no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Genovesi, S., Giussani, M., Orlando, A. et al. Prevention of Cardiovascular Diseases in Children and Adolescents. High Blood Press Cardiovasc Prev 26, 191–197 (2019). https://doi.org/10.1007/s40292-019-00316-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40292-019-00316-6

Keywords

Navigation