Abstract
Purpose
Hypertension is associated with dyslipidemia. Thiazides adversely affect serum lipid levels in hypertensives. There is currently a dearth of information on benefits of aerobic exercise training on serum lipid levels in individuals on thiazides and this study aimed at bridging this gap in knowledge.
Methods
This randomized-controlled trial involved 120 newly-diagnosed adults with essential hypertension (≥65 years). They were treated with 50 mg of hydrochlorothiazide + 5 mg of hydrochloride amiloride and 5 or 10 mg of amlodipine for 4–6 weeks before they were randomly assigned into exercise group (EG) and control croup (CG). Only EG underwent 12-week aerobic dance training at 50–70 % of heart rate reserve three times per week. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglyceride and total cholesterol were measured and recorded at baseline and post-study.
Results
Eighty-eight (45 in EG and 43 in CG) of 120 participants randomly assigned to groups completed the study. Systolic (p = 0.370) and diastolic (p = 0.771) blood pressures (BP) were similar between the two groups at baseline. Systolic (p < 0.001) and diastolic (p < 0.001) BPs reduced significantly in exercise and control groups. LDL-C (from 120.10 ± 33.41 to 110.50 ± 31.68 mg/dl; p = 0.037) and triglyceride (from 117.49 ± 45.12 to 100.63 ± 35.42 mg/dl; p = 0.002) decreased in EG post-study but no significant between-group differences were observed.
Conclusions
Although, LDL-C and triglyceride are reduced after aerobic dance training, they were not any more than without it. Aerobic dance training has favorable effects on LDL-C, triglyceride, and systolic and diastolic BP in individuals with hypertension on a thiazide.
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Acknowledgments
This work was supported by African Doctoral Dissertation Research Fellowship offered by the African Population and Health Research Center (APHRC), Kenya in partnership with the International Development Research Centre (IDRC) and Ford Foundation, and Neimeth Pharmaceutical Plc, Nigeria. We thank all participants who volunteered and the staff of Chronic Disease Research Project, University College Hospital, Ibadan, Nigeria, for their assistance.
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Trial Registration Number: ISRCTN81952488; http://www.controlled-trials.com/ISRCTN81952488/.
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Maruf, F.A., Akinpelu, A.O. & Salako, B.L. A Randomized Controlled Trial of the Effects of Aerobic Dance Training on Blood Lipids Among Individuals with Hypertension on a Thiazide. High Blood Press Cardiovasc Prev 21, 275–283 (2014). https://doi.org/10.1007/s40292-014-0063-2
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DOI: https://doi.org/10.1007/s40292-014-0063-2