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Drug-Induced Kidney Injury in the Elderly

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Abstract

The incidence of acute kidney injury in the elderly has grown over the past decade. One of the primary drivers is drug-induced nephrotoxicity, which is the result of a combination of the unique susceptibilities to kidney injury and the increased use of medications in the elderly population. Specific drug classes are associated with increased rates of kidney injury including agents that block the renin angiotensin system, antimicrobials, and chemotherapeutic agents. Mechanistically, injury may be due to hemodynamic effects, tubular or glomerular toxicity, and interstitial nephritis. Early recognition of nephrotoxicity is critical, as are preventative steps when applicable. Unfortunately, treatment for established drug-induced kidney injury is limited and supportive care is required. Limiting exposure to nephrotoxic drugs is critical in decreasing the incidence of acute kidney injury in the elderly patient.

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References

  1. United Nations world population prospects, the 2015 revision. http://esa.un.org/unpd/wpp/Publications/Files/WPP2015_Volume-II-Demographic-Profiles.pdf. Accessed 18 July 2017.

  2. United States Census Bureau. https://www.census.gov/quickfacts/table/PST045216/00. Accessed 18 July 2017.

  3. Schissler MM, Zaidi S, Kumar H, et al. Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury. Nephrology. 2013;18:183–7.

    Article  PubMed  Google Scholar 

  4. USRDS annual data report. http://www.usrds.org/2016/view/Default.aspx. Accessed 18 July 2017.

  5. Himmelfarb J, Ikizler TA. Acute kidney injury: changing lexicography, definitions, and epidemiology. Kidney Int. 2007;10:971–6.

    Article  Google Scholar 

  6. Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure: definition, outcome measures, animal models, fluid therapy and information technology needs. The second international consensus conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;4:204–12.

    Article  Google Scholar 

  7. Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;2:R31.

    Article  Google Scholar 

  8. Kidney Disease Improving Global Outcomes. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2011;1:8–12.

    Google Scholar 

  9. Awidshu L, Mehta RL. The 6Rs of drug induced nephrotoxicity. BMC Nephrol. 2017;8:124. doi:10.1186/s12882-017-0536-3.

    Article  Google Scholar 

  10. Mehta RL, Awidshu L, Davenport A, et al. Phenotype standardization for drug-induced kidney disease. Kidney Int. 2015;88:226–34.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ishani A, Xue JL, Himmelfarb J, et al. Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009;20:223–8.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Xue JL, Daniels F, Star RA, et al. Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol. 2006;17:1135–42.

    Article  PubMed  Google Scholar 

  13. Ali T, Khan I, Simpson W, et al. Incidence and outcomes in acute kidney injury: a comprehensive population-based study. J Am Soc Nephrol. 2007;18:1292–8.

    Article  CAS  PubMed  Google Scholar 

  14. Talabani B, Zouwaii S, Pyart RD, et al. Epidemiology and outcome of community acquired acute kidney injury. Nephrology. 2014;19:282–7.

    Article  PubMed  Google Scholar 

  15. Pascual J, Orofino L, Liano F, et al. Incidence and prognosis of acute renal failure in older patients. J Am Geriatr Soc. 1990;38:25–30.

    Article  CAS  PubMed  Google Scholar 

  16. Hsu RK, McCulloch CE, Dudley RA, et al. Temporal changes in the incidence of dialysis-requiring AKI. J Am Soc Nephrol. 2013;24:37–42.

    Article  PubMed  Google Scholar 

  17. Jha V, Malhotra HS, Saukhuja V, et al. Spectrum of hospital acquired acute renal failure in the developing countries: Chandigarh study. Q J Med. 1992;83:497–505.

    CAS  PubMed  Google Scholar 

  18. Mahajan S, Tiwari S, Bhowmik D, et al. Factors affecting the outcome of acute renal failure among the elderly population in India: a hospital based study. Int Urol Nephrol. 2006;38:391–6.

    Article  PubMed  Google Scholar 

  19. Kohli HS, Bhat A, Aravindan AN, et al. Predictors of mortality in elderly patients with acute renal failure in a developing country. Int Urol Nephrol. 2007;39:339–44.

    Article  PubMed  Google Scholar 

  20. Kohli HS, Bhaskaran MC, Muthukumar T, et al. Treatment-related acute renal failure in the elderly: a hospital-based prospective study. Nephrol Dial Transplant. 2000;15:212–7.

    Article  CAS  PubMed  Google Scholar 

  21. Baraldi A, Ballestri M, Rapana R, et al. Acute renal failure of medical type in an elderly population. Nephrol Dial Transplant. 1998;13(Suppl. 7):25–9.

    Article  PubMed  Google Scholar 

  22. Nash K, Hafeez A, Hou S. Hospital-acquired renal insufficiency. Am J Kidney Dis. 2002;39:930–6.

    Article  PubMed  Google Scholar 

  23. Li Q, Zhao M, Du J, et al. Outcomes of renal function in elderly patients with acute kidney injury. Clin Interv Aging. 2017;12:153–60.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Sesso R, Roque A, Vicioso B, Stella S. Prognosis of ARF in hospitalized elderly patients. Am J Kidney Dis. 2004;44:410–9.

    Article  PubMed  Google Scholar 

  25. Hsu CN, Lee CT, Su CH, et al. Incidence, outcomes and risk factors of community-acquired and hospital-acquired acute kidney injury: a retrospective cohort study. Medicine (Baltimore). 2016;95:e3674.

    Article  Google Scholar 

  26. Denic A, Lieske JC, Chakkera HA, et al. The substantial loss of nephrons in healthy human kidneys with aging. J Am Soc Nephrol. 2017;28:313–20.

    Article  PubMed  Google Scholar 

  27. Lindeman RD. Overview: renal physiology and pathophysiology of aging. Am J Kidney Dis. 1990;16:275–82.

    Article  CAS  PubMed  Google Scholar 

  28. Lindeman RD, Goldman R. Anatomic and physiologic age changes in the kidney. Exp Gerontol. 1986;21:379–406.

    Article  CAS  PubMed  Google Scholar 

  29. Abdel-Kader K, Palevsky P. Acute kidney injury in the elderly. Clin Geriatr Med. 2009;25:331–58.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Abdel-Rahman EM, Okusa MD. Effects of aging on renal function and regenerative capacity. Nephrol Clin Pract. 2014;127:15–20.

    Article  Google Scholar 

  31. Lindeman RD, Tobin J, Shock NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 1985;33:278–85.

    Article  CAS  PubMed  Google Scholar 

  32. Schmitt R, Cantley LG. The impact of aging on kidney repair. Am J Physiol Renal Physiol. 2008;294:1265–72.

    Article  CAS  Google Scholar 

  33. Aymanns C, Keller F, Maus S, et al. Review on pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol. 2010;5:314–27.

    Article  CAS  PubMed  Google Scholar 

  34. Rosner MH. Acute kidney injury in the elderly. Clin Geriatr Med. 2013;29:565–78.

    Article  PubMed  Google Scholar 

  35. Fliser D, Zeier M, Nowack R, Ritz E. Renal functional reserve in healthy elderly subjects. J Am Soc Nephrol. 1993;3:1371–7.

    CAS  PubMed  Google Scholar 

  36. Cheung CM, Ponnusamy A, Anderton JG. Management of acute renal failure in the elderly patient: a clinician’s guide. Drugs Aging. 2008;25:455–76.

    Article  CAS  PubMed  Google Scholar 

  37. Scondotto G, Pojero F, Addario P, et al. The impact of polypharmacy and drug interactions among the elderly population in Western Sicily, Italy. Aging Clin Exp Res. 2017. doi:10.1007/s40520-017-0755-2.

    PubMed  Google Scholar 

  38. Chang YP, Huang SK, Tao P. A population-based study on the association between acute renal failure (ARF) and the duration of polypharmacy. BMC Nephrol. 2012;13:96.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Schetz M, Dasta J, Goldstein S, et al. Drug-induced kidney injury. Curr Opin Crit Care. 2006;11:555–65.

    Article  Google Scholar 

  40. Pannu N, Nadim M. An overview of drug-induced acute kidney injury. Crit Care Med. 2008;36(4 Suppl.):S216–23.

    Article  CAS  PubMed  Google Scholar 

  41. Chronopoulos A, Cruz DN, Ronco C. Hospital-acquired acute kidney injury in the elderly. Nat Rev Nephrol. 2010;6:141–9.

    Article  PubMed  Google Scholar 

  42. Dreischulte T, Morales DR, Bell S, Guthrie B. Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin–angiotensin system inhibitors in the community increases the risk of acute kidney injury. Kidney Int. 2015;88:396–403.

    Article  CAS  PubMed  Google Scholar 

  43. Barros EJ, Boim MA, Ajzen H, et al. Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity. Kidney Int. 1987;32:19–25.

    Article  CAS  PubMed  Google Scholar 

  44. First MR, Schroeder TJ, Alexander JW, et al. Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients. Transplantation. 1991;51:365–70.

    Article  CAS  PubMed  Google Scholar 

  45. Morrissey KM, Stocker SL, Wittwer MB, et al. Renal transporters in drug development. Annu Rev Pharmacol Toxicol. 2013;53:503–29.

    Article  CAS  PubMed  Google Scholar 

  46. Mahadevappa R, Nielsen R, Christensen EI, Birn H. Megalin in acute kidney injury: foe and friend. Am J Physiol Renal Physiol. 2014;306:F147–54.

    Article  CAS  PubMed  Google Scholar 

  47. Perazella MA. Drug-induced nephropathy: an update. Expert Opin Drug Saf. 2005;4:689–706.

    Article  CAS  PubMed  Google Scholar 

  48. Humes HD. Aminoglycoside nephrotoxicity. Kidney Int. 1988;33:900–11.

    Article  CAS  PubMed  Google Scholar 

  49. Anaisse EJ, Vartivarian ES, Abi-Said D, et al. Fluconazole vs amphotericin B in the treatment of hematogenous candidiasis. Am J Med. 1996;101:170–6.

    Article  Google Scholar 

  50. National Institute of Allergy and Infectious Diseases Mycoses Study Group, Walsh TJ, Finberg RW, Arndt C, et al. Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. N Engl J Med. 1999;340:764–71.

    Article  Google Scholar 

  51. Hidayat LK, Hsu DI, Quist R, et al. High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity. Arch Intern Med. 2006;166:2138–44.

    Article  PubMed  Google Scholar 

  52. Luque Y, Louis K, Jounneau C, et al. Vancomycin-associated cast nephropathy. J Am Soc Nephrol. 2017;28:1723–8.

    Article  PubMed  Google Scholar 

  53. Markowitz GS, Bomback AS, Perazella MA. Drug-induced glomerular disease: direct cellular injury. Clin J Am Soc Nephrol. 2015;10:1291–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Izzedine H, Escudier B, Lhomme C, et al. Kidney diseases associated with anti-vascular endothelial growth factor (VEGF): an 8 year observational study at a single center. Medicine (Baltimore). 2014;93:333–9.

    Article  CAS  Google Scholar 

  55. Michel DM, Kelly CJ. Acute interstitial nephritis. J Am Soc Nephrol. 1998;9:506–15.

    CAS  PubMed  Google Scholar 

  56. Markowitz GS, Perazella MA. Drug-induced renal failure: a focus on tubulointerstitial disease. Clin Chim Acta. 2005;35:31–47.

    Article  CAS  Google Scholar 

  57. Zeller V, Puyraimond-Zemmour D, Sené T, et al. Amoxicillin crystalluria, an emerging complication with an old and well-known antibiotic. Antimicrob Agents Chemother. 2016;60:3248. doi:10.1128/AAC.00359-16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Secoli SR. Polypharmacy: interaction and adverse reactions in the use of drugs by elderly people. Rev Bras Enferm. 2010;63:136–40.

    Article  PubMed  Google Scholar 

  59. Scondotto G, Pojero F, Addario P, et al. The impact of polypharmacy and drug interactions among the elderly population in Western Sicily, Italy. Aging Clin Exp Res. 2017. doi:10.1007/s40520-017-0755-2.

    PubMed  Google Scholar 

  60. Coca SG. Acute kidney injury in elderly persons. Am J Kidney Dis. 2010;56:122–31.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Murithi AK, Leung N, Valeri AM, et al. Biopsy-proven acute interstitial nephritis, 1993–2011: a case series. Am J Kidney Dis. 2014;64:558–66.

    Article  Google Scholar 

  62. Muriithi AK, Nasr SH, Leung N. Utility of urine eosinophils in the diagnosis of acute interstitial nephritis. Clin J Am Soc Nephrol. 2013;8:1857–62.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Nair R, Bell JM, Walker PD. Renal biopsy in patients over 80 years and older. Am J Kidney Dis. 2004;44:618–26.

    Article  PubMed  Google Scholar 

  64. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–12.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2012;2013(3):1–150.

    Google Scholar 

  66. Schaeffner ES, Ebert N, Delanaye P, et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012;157:471–81.

    Article  PubMed  Google Scholar 

  67. Alshaer IM, Kilbride HS, Stevens PE, et al. External validation of the Berlin equations for the estimation of GFR in the elderly. Am J Kidney Dis. 2014;63:862–5.

    Article  PubMed  Google Scholar 

  68. Dowling TC, Wang ES, Ferrucci L, Sorkin JD. Glomerular filtration rate equations overestimate creatinine clearance in older individuals enrolled in the Baltimore Longitudinal Study on Aging: impact on renal drug dosing. Pharmacotherapy. 2013;33:912–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Helldén A, Odar-Cederlöf I, Nilsson G, et al. Renal function estimations and dose recommendations for dabigatran, gabapentin and valaciclovir: a data simulation study focused on the elderly. BMJ Open. 2013;3:e002686. doi:10.1136/bmjopen-2013-002686.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Hori Y, Aoki N, Kuwahara S, et al. Megalin blockade with cilastatin suppresses drug-induced nephrotoxicity. J Am Soc Nephrol. 2017;28:1783–91.

    Article  PubMed  Google Scholar 

  71. Usui J, Yamagata K, Imai E, et al. Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version. Clin Exp Nephrol. 2016;20:827–31.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Muriithi AK, Leung N, Valeri AM, et al. Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly. Kidney Int. 2015;87:458–64.

    Article  CAS  PubMed  Google Scholar 

  73. Paueksakon P, Fogo AB. Drug-induced nephropathies. Histopathology. 2017;70:94–108.

    Article  PubMed  Google Scholar 

  74. Pazhayattil GS, Shirali AC. Drug-induced impairment of renal function. Int J Nephrol Renovasc Dis. 2014;7:457–68.

    PubMed  PubMed Central  Google Scholar 

  75. De Broe ME, Elseviers MM. Over-the-counter analgesic use. J Am Soc Nephrol. 2009;20:2098–103.

    Article  PubMed  CAS  Google Scholar 

  76. Radford MG Jr, Holley KE, Grande JP, et al. Reversible membranous nephropathy associated with the use of nonsteroidal anti-inflammatory drugs. JAMA. 1996;276:466–9.

    Article  CAS  PubMed  Google Scholar 

  77. Mansfield KE, Nitsch D, Smeeth L, et al. Prescription of renin–angiotensin system blockers and risk of acute kidney injury: a population-based cohort study. BMJ Open. 2016;6:e012690. doi:10.1136/bmjopen-2016-012690.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Chaumont M, Pourcelet A, van Nuffelen M, et al. Acute kidney injury in elderly patients with chronic kidney disease: do angiotensin-converting enzyme inhibitors carry a risk? J Clin Hypertens (Greenwich). 2016;18:514–21.

    Article  CAS  Google Scholar 

  79. Lapi F, Azoulay L, Yin H, et al. Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. BMJ. 2013;346:e8525. doi:10.1136/bmj.e8525.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Morris RL, Ashcroft D, Phipps D, et al. Preventing acute kidney injury: a qualitative study exploring ‘sick day rules’ implementation in primary care. BMC Fam Pract. 2016;17:91. doi:10.1186/s12875-016-0480-5.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Mizokami F, Mizuno T. Acute kidney injury induced by antimicrobial agents in the elderly: awareness and mitigation strategies. Drugs Aging. 2015;32:1–12.

    Article  CAS  PubMed  Google Scholar 

  82. Denamur S, Tyteca D, Marchand-Brynaert J, et al. Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic. Free Radic Biol Med. 2011;51:1656–65.

    Article  CAS  PubMed  Google Scholar 

  83. de Souza MC, Santos AG, Reis AM. Adverse drug reactions in patients receiving systemic antifungal therapy at a high-complexity hospital. J Clin Pharmacol. 2016;56:1507–15.

    Article  PubMed  CAS  Google Scholar 

  84. Wade RL, Chaudhari P, Natoli JL, et al. Nephrotoxicity and other adverse events among inpatients receiving liposomal amphotericin B or amphotericin B lipid complex. Diagn Microbiol Infect Dis. 2013;76:361–7.

    Article  CAS  PubMed  Google Scholar 

  85. Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009;66:82–98.

    Article  CAS  PubMed  Google Scholar 

  86. Barber KE, Bell AM, Stover KR, Wagner JL. Intravenous vancomycin dosing in the elderly: a focus on clinical issues and practical application. Drugs Aging. 2016;33:845–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Rutter WC, Burgess DR, Talbert JC, Burgess DS. Acute kidney injury in patients treated with vancomycin and piperacillin–tazobactam: a retrospective cohort analysis. J Hosp Med. 2017;12:77–82.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Viehman JA, Oleksiuk LM, Sheridan KR, et al. Adverse events lead to drug discontinuation more commonly among patients who receive nafcillin than among those who receive oxacillin. Antimicrob Agents Chemother. 2016;60:3090–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Jensen JU, Hein L, Lundgren B, Procalcitonin And Survival Study (PASS) Group, et al. Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial. BMJ Open. 2012;2:e000635. doi:10.1136/bmjopen-2011-000635.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Gluhovschi G, Gadalean F, Gluhovschi C, et al. Is ciprofloxacin safe in patients with solitary kidney and upper urinary tract infection? Biomed Pharmacother. 2016;84:366–72.

    Article  CAS  PubMed  Google Scholar 

  91. Stratta P, Lazzarich E, Canavese C, et al. Ciprofloxacin crystal nephropathy. Am J Kidney Dis. 2007;50:330–5.

    Article  PubMed  Google Scholar 

  92. Fraser TN, Avellaneda AA, Graviss EA, Musher DM. Acute kidney injury associated with trimethoprim/sulfamethoxazole. J Antimicrob Chemother. 2012;67:1271–7.

    Article  CAS  PubMed  Google Scholar 

  93. Izzedine H, Launay-Vacher V, Deray G. Antiviral drug-induced nephrotoxicity. Am J Kidney Dis. 2005;45:804–17.

    Article  CAS  PubMed  Google Scholar 

  94. Naesens M, Kuypers DR, Sarwal M. Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol. 2009;4:481–508.

    CAS  PubMed  Google Scholar 

  95. Issa N, Kukla A, Ibrahim HN. Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. Am J Nephrol. 2013;37:602–12.

    Article  CAS  PubMed  Google Scholar 

  96. Jacobson PA, Schladt D, Oetting WS, et al. Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs. Am J Transplant. 2012;12:3326–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Andò G, Morabito G, de Gregorio C, et al. Age, glomerular filtration rate, ejection fraction, and the AGEF score predict contrast-induced nephropathy in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Catheter Cardiovasc Interv. 2013;82:878–85.

    Article  PubMed  Google Scholar 

  98. Kagan A, Sheikh-Hamad D. Contrast-induced kidney injury: focus on modifiable risk factors and prophylactic strategies. Clin Cardiol. 2010;33:62–6.

    Article  PubMed  Google Scholar 

  99. Zhang B, Liang L, Chen W, et al. The efficacy of sodium bicarbonate in preventing contrast-induced nephropathy in patients with pre-existing renal insufficiency: a meta-analysis. BMJ Open. 2015;5:e006989. doi:10.1136/bmjopen-2014-006989.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Sun Z, Fu Q, Cao L, et al. Intravenous N-acetylcysteine for prevention of contrast-induced nephropathy: a meta-analysis of randomized, controlled trials. PLoS One. 2013;8:e55124. doi:10.1371/journal.pone.0055124.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Bocchetta A, Ardau R, Fanni T, et al. Renal function during long-term lithium treatment: a cross-sectional and longitudinal study. BMC Med. 2015;13:12. doi:10.1186/s12916-014-0249-4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  102. Delcher A, Hily S, Boureau AS, et al. Multimorbidities and overprescription of proton pump inhibitors in older patients. PLoS One. 2015;10:e0141779. doi:10.1371/journal.pone.0141779.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  103. Geevasinga N, Coleman PL, Webster AC, Roger SD. Proton pump inhibitors and acute interstitial nephritis. Clin Gastroenterol Hepatol. 2006;4:597–604.

    Article  CAS  PubMed  Google Scholar 

  104. Arora P, Gupta A, Golzy M, et al. Proton pump inhibitors are associated with increased risk of development of chronic kidney disease. BMC Nephrol. 2016;17:112. doi:10.1186/s12882-016-0325-4.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Xie Y, Bowe B, Li T, et al. Proton pump inhibitors and risk of incident CKD and progression to ESRD. J Am Soc Nephrol. 2016;27:3153–63.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Brodsky SV, Nadasdy T, Rovin BH, et al. Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate. Kidney Int. 2011;80:181–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Ng CY, Tan CS, Chin CT, et al. Warfarin related nephropathy: a case report and review of the literature. BMC Nephrol. 2016;17:15. doi:10.1186/s12882-016-0228-4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  108. Yang Y, Liu T, Zhao J, Li G. Warfarin-related nephropathy: prevalence, risk factors and prognosis. Int J Cardiol. 2014;176:1297–8.

    Article  PubMed  Google Scholar 

  109. Becker MA, Fitz-Patrick D, Choi HK, et al. An open-label, 6-month study of allopurinol safety in gout: the LASSO study. Semin Arthritis Rheum. 2015;45:174–83.

    Article  CAS  PubMed  Google Scholar 

  110. Mallappallil M, Sabu J, Friedman EA, Salifu M. What do we know about opioids and the kidney? Int J Mol Sci. 2017;18:E223. doi:10.3390/ijms18010223.

    Article  PubMed  Google Scholar 

  111. Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol. 2008;4:2–6.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Muthukumar T, Jayakumar M, Fernando EM, Muthusethupathi MA. Acute renal failure due to rifampicin: a study of 25 patients. Am J Kidney Dis. 2002;40:690–6.

    Article  CAS  PubMed  Google Scholar 

  113. Min HK, Kim EO, Lee SJ, et al. Rifampin-associated tubulointersititial nephritis and Fanconi syndrome presenting as hypokalemic paralysis. BMC Nephrol. 2013;14:13. doi:10.1186/1471-2369-14-13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. De Vriese AS, Robbrecht DL, Vanholder RC, et al. Rifampicin-associated acute renal failure: pathophysiologic, immunologic, and clinical features. Am J Kidney Dis. 1998;31:108–15.

    Article  PubMed  Google Scholar 

  115. Covic A, Goldsmith DJ, Segall L, et al. Rifampicin-induced acute renal failure: a series of 60 patients. Nephrol Dial Transplant. 1998;13:924–9.

    Article  CAS  PubMed  Google Scholar 

  116. Prieto-García L, Pericacho M, Sancho-Martínez SM, et al. Mechanisms of triple whammy acute kidney injury. Pharmacol Ther. 2016;167:132–45.

    Article  PubMed  CAS  Google Scholar 

  117. Takeuchi S, Kotani Y, Tsujimoto T. Hypotension induced by the concomitant use of a calcium-channel blocker and clarithromycin. BMJ Case Rep. 2017. doi:10.1136/bcr-2016-218388.

    PubMed Central  Google Scholar 

  118. Mishima E, Maruyama K, Nakazama T, et al. Acute kidney injury from excessive potentiation of calcium-channel blocker via synergistic CYP3A4 inhibition by clarithromycin plus voriconazole. Intern Med. 2017;56:1687–90.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Patel AM, Shariff S, Bailey DG, et al. Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study. Ann Intern Med. 2013;158:869–76.

    Article  PubMed  Google Scholar 

  120. Alreja G, Inayatullah S, Goel S, Braden G. Rhabdomyolysis caused by an unusual interaction between azithromycin and simvastatin. J Cardiovasc Dis Res. 2012;3:319–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  121. Wong PW, Dillard TA, Kroenke K. Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy. South Med J. 1998;91:202–5.

    Article  CAS  PubMed  Google Scholar 

  122. Wang YC, Hsieh TC, Chou CL, et al. Risks of adverse events following coprescription of statins and calcium channel blockers: a nationwide population-based study. Medicine (Baltimore). 2016;95:e2487. doi:10.1097/MD.0000000000002487.

    Article  CAS  Google Scholar 

  123. Banakh I, Haji K, Kung R, et al. Severe rhabdomyolysis due to presumed drug interactions between atorvastatin with amlodipine and ticagrelor. Case Rep Crit Care. 2017;2017:3801819. doi:10.1155/2017/3801819.

    PubMed  PubMed Central  Google Scholar 

  124. Teutonico A, Libutti P, Lomonte C, Basile C. Simvastatin- induced myoglobinuric acute kidney injury following ciclosporin treatment for alopecia universalis. Nephrol Dial Transplant. 2010;3:273–5.

    Google Scholar 

  125. Scarfia RV, Clementi A, Granata A. Rhabdomyolysis and acute kidney injury secondary to interaction between simvastatin and cyclosporine. Ren Fail. 2013;35:1056–7.

    Article  CAS  PubMed  Google Scholar 

  126. Kusus M, Stapleton DD, Lertora JJ, et al. Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions. Am J Med Sci. 2000;320:394–7.

    Article  CAS  PubMed  Google Scholar 

  127. Wang Q, Zheng M, Leil T. Investigating transporter-mediated drug-drug interactions using a physiologically based pharmacokinetic model of rosuvastatin. CPT Pharmacometrics Syst Pharmacol. 2017;6:228–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Ellison NM, Servi RJ. Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: a possible adverse effect due to concomitant indomethacin administration. Cancer Treat Rep. 1985;69:342–3.

    CAS  PubMed  Google Scholar 

  129. Maiche AG. Acute renal failure due to concomitant action of methotrexate and indomethacin. Lancet. 1986;1:1390.

    Article  CAS  PubMed  Google Scholar 

  130. Singh RR, Malaviya AN, Pandey JN, Guleria JS. Fatal interaction between methotrexate and naproxen. Lancet. 1986;1:1390.

    Article  CAS  PubMed  Google Scholar 

  131. Avent CK, Krinsky D, Kirklin JK, et al. Synergistic nephrotoxicity due to ciprofloxacin and cyclosporine. Am J Med. 1988;85:452–3.

    Article  CAS  PubMed  Google Scholar 

  132. Elston RA, Taylor J. Possible interaction of ciprofloxacin with cyclosporin A. J Antimicrob Chemother. 1988;21:679–80.

    Article  CAS  PubMed  Google Scholar 

  133. Nasir M, Rotellar C, Hand M, et al. Interaction between ciclosporin and ciprofloxacin. Nephron. 1991;57:245–6.

    Article  CAS  PubMed  Google Scholar 

  134. Burgess LD, Drew RH. Comparison of the incidence of vancomycin-induced nephrotoxicity in hospitalized patients with and without concomitant piperacillin–tazobactam. Pharmacotherapy. 2014;34:670–6.

    Article  CAS  PubMed  Google Scholar 

  135. Cabanillas F, Burgos RC, Rodriguez C, Baldizon C. Nephrotoxicity of combined cephalothin-gentamicin regimen. Arch Intern Med. 1975;135:850–2.

    Article  CAS  PubMed  Google Scholar 

  136. Drew JH, Watson A, Evans JH, Smyth AR. Antibiotics and acute renal failure in children with cystic fibrosis. Paediatr Perinatal Drug Ther. 2002;5:65–7.

    Article  Google Scholar 

  137. Fillastre JP, Laumonier R, Humbert G, et al. Acute renal failure associated with combined gentamicin and cephalothin therapy. Br Med J. 1973;2:396–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  138. Workeneh B, Sangsiraprapha W, Addison D, Longfield E. A novel case of persistent Bartters-like syndrome associated with gentamicin exposure. Saudi J Kidney Dis Transpl. 2013;24:144–6.

    Article  PubMed  Google Scholar 

  139. Mo L, He J, Yue Q, et al. Increased dosage of cyclosporine induces myopathy with increased serum creatine kinase in an elderly patient on chronic statin therapy. J Clin Pharm Ther. 2015;40:245–8.

    Article  CAS  PubMed  Google Scholar 

  140. Rifkin S. Multiple drug interactions in a renal transplant patient leading to simvastatin-induced rhabdomyolysis: a case report. Medscape J Med. 2008;10:264.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Division of Nephrology, University of Virginia Health System, Box 800133 HSC, Charlottesville, VA, 22903, USA

    Sana Khan & Mitchell H. Rosner

  2. Divisione di Nefrologia e Dialisi, Azienda Ospedaliera Brotzu, Cagliari, Italy

    Valentina Loi

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  1. Sana Khan
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  2. Valentina Loi
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Correspondence to Mitchell H. Rosner.

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Sana Khan, Valentina Loi, and Mitchell H. Rosner have no conflicts of interest directly relevant to the contents of this article.

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Khan, S., Loi, V. & Rosner, M.H. Drug-Induced Kidney Injury in the Elderly. Drugs Aging 34, 729–741 (2017). https://doi.org/10.1007/s40266-017-0484-4

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