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Bevacizumab: A Review of Its Use in Advanced Cancer

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Abstract

The humanized monoclonal antibody bevacizumab (Avastin®) has been available in the EU since 2005. Results of phase III trials demonstrate that adding intravenous bevacizumab to antineoplastic agents improves progression-free survival and/or overall survival in patients with advanced cancer, including when used as first- or second-line therapy in metastatic colorectal cancer, as first-line therapy in advanced nonsquamous non-small cell lung cancer, as first-line therapy in metastatic renal cell carcinoma, as first-line therapy in metastatic breast cancer, and as first-line therapy in epithelial ovarian, fallopian tube or primary peritoneal cancer or in recurrent, platinum-sensitive or platinum-resistant disease. Results of these studies are supported by the findings of routine oncology practice studies conducted in real-world settings. The tolerability profile of bevacizumab is well defined and adverse events associated with its use (e.g. hypertension, proteinuria, haemorrhage, wound healing complications, arterial thromboembolism, gastrointestinal perforation) are generally manageable. In conclusion, bevacizumab remains an important option for use in patients with advanced cancer.

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Disclosure

The preparation of this review was not supported by any external funding. Gillian Keating is a salaried employee of Adis/Springer. During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on this article. Changes resulting from comments received were made by the author on the basis of scientific and editorial merit.

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The manuscript was reviewed by: A. Bamias, Department of Clinical Therapeutics, University of Athens, Athens, Greece; B. Melichar, Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic; P. Wimberger, Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany.

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Keating, G.M. Bevacizumab: A Review of Its Use in Advanced Cancer. Drugs 74, 1891–1925 (2014). https://doi.org/10.1007/s40265-014-0302-9

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