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Cell Therapy for Multiple Sclerosis

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Abstract

Cell therapy is considered a promising potential treatment for multiple sclerosis, perhaps particularly for the progressive form of the disease for which there are currently no useful treatments. Over the past two decades or more, much progress has been made in understanding the biology of MS and in the experimental development of cell therapy for this disease. Three quite distinct forms of cell therapy are currently being pursued. The first seeks to use stem cells to replace damaged myelin-forming oligodendrocytes within the CNS; the second aims, in effect, to replace the individual’s misfunctioning immune system, making use of haematopoietic stem cells; and the third seeks to utilise endogenous stem cell populations by mobilisation with or without in vitro expansion, exploiting their various reparative and neuroprotective properties. In this article we review progress in these three separate areas, summarising the experimental background and clinical progress thus far made.

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Authors and Affiliations

  1. Institute of Clinical Neurosciences, Southmead Hospital, University of Bristol, L&R Building, Bristol, BS10 5NB, UK

    Pamela Sarkar, Claire M. Rice & Neil J. Scolding

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  1. Pamela Sarkar
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  2. Claire M. Rice
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Correspondence to Neil J. Scolding.

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Pamela Sarkar was funded by a grant from the Silverman Family Foundation

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Pamela Sarkar, Claire M. Rice, Neil J. Scolding report no relevant conflicts of interest.

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Sarkar, P., Rice, C.M. & Scolding, N.J. Cell Therapy for Multiple Sclerosis. CNS Drugs 31, 453–469 (2017). https://doi.org/10.1007/s40263-017-0429-9

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  • DOI: https://doi.org/10.1007/s40263-017-0429-9

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