Skip to main content
Log in

A Systematic Review on the Extent and Quality of Pharmacoeconomic Publications in Egypt

  • Systematic Review
  • Published:
Clinical Drug Investigation Aims and scope Submit manuscript

Abstract

Background

Egypt faces many challenges when matching patient needs with available resources. Consequently, there has been an increasing interest in pharmacoeconomics as an aid tool in health decision-making to better allocate resources.

Objectives

To review and evaluate the volume and the quality of published pharmacoeconomic studies in Egypt.

Methods

A literature search was conducted in August 2018 using PubMed, Google Scholar, and Cochrane library to identify published Egyptian pharmacoeconomic studies. Articles were included if they were original economic studies, written and published in English, and conducted in Egypt. Each article was assessed independently by two reviewers using the 100-point Quality of Health Evaluation Studies (QHES) scale.

Results

Fifteen studies published between 2002 and 2017 were included in the review. Most of them were cost-effectiveness analyses (60%). The minority used secondary data (33.3%) or adopted modeling techniques (40%). The mean QHES score of the included studies was 70.1 ± 21.8, and approximately 40% of them had a QHES score of more than 80.

Conclusion

Pharmacoeconomic evaluations in Egypt are still in their infancy. The Egyptian guidelines for economic evaluation should be adopted and the EQ-5D-5L value sets should be developed to increase the quality of economic research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Central Agency for Public Mobilization and Statistics—CAPMAS 2014/2015. Official site. http://capmas.gov.eg/. Accessed 12 Dec 2016.

  2. World bank official site. http://data.worldbank.org/?locations=XN-EG. Accessed 12 Dec 2016.

  3. Abdou DS, Zaazou Z. The Egyptian revolution and post socio-economic impact. Topics in Middle Eastern and African Economies 2013.

  4. National Health Accounts (NHA) 2008/2009 report https://www.hfgproject.org/wp-content/uploads/2015/02/Egypt-National-Health-Accounts-2008_09.pdf. Accessed 12 Dec 2016.

  5. Health Insurance Organization (HIO). http://www.hio.gov.eg/Ar/covers/Pages/Charts4.aspx. Accessed 12 Dec 2016.

  6. Canadian Coordinating Office for Health Technology Assessment, Guidelines for Economic Evaluation of Pharmacoeconomics: Canada. 2nd ed. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1994. https://www.cadth.ca/media/pdf/peg_e.pdf. Accessed 14 Dec 2016.

  7. Australia. Department of Human Services and Health: Guidelines for the pharmaceutical industry on preparation of submissions to the Pharmaceutical Benefits Advisory Committee: including major submissions involving economic analyses, November 1995 Canberra: Australian Govt. Pub. Service; 1995.

  8. DiMasi JA, Caglarcan E, Wood-Armany M. Emerging role of pharmacoeconomics in the research and development decision-making process. Pharmacoeconomics. 2001;19(7):753–66.

    Article  CAS  PubMed  Google Scholar 

  9. Greenberg MPE, Arcelus A, Birnbaum HG, Cremieux P-Y, LeLorier J, Ouellette P, et al. Pharmacoeconomics and health policy. Pharmacoeconomics. 1999;16(5):425–32.

    Article  CAS  PubMed  Google Scholar 

  10. Johnson JA, Friesen E. Reassessing the relevance of pharmacoeconomic analyses in formulary decisions. Pharmacoeconomics. 1998;13(5 Pt 1):479–85.

    Article  CAS  PubMed  Google Scholar 

  11. Elsisi GH, Kaló Z, Eldessouki R, Elmahdawy MD, Saad A, Ragab S, et al. Recommendations for reporting pharmacoeconomic evaluations in Egypt. Value Health Reg Issues. 2013;2(2):319–27.

    Article  PubMed  Google Scholar 

  12. Gavaza P, Rascati K, Brown C, Lawson K, Mann T. The state of health economic and pharmacoeconomic evaluation research in Zimbabwe: a review. Curr Ther Res. 2008;69(3):268–85.

    Article  PubMed  Google Scholar 

  13. Sullivan S, Lyles A, Luce B, Grigar J. AMCP guidance for submission of clinical and economic evaluation data to support formulary listing in US health plans and pharmacy benefits management organizations. J Manag Care Pharm. 2001;7(4):272–82.

    Google Scholar 

  14. Zarnke KB, Levine MA, O’Brien BJ. Cost-benefit analyses in the health-care literature: don’t judge a study by its label. J Clin Epidemiol. 1997;50(7):813–22.

    Article  CAS  PubMed  Google Scholar 

  15. Ofman JJ, Sullivan SD, Neumann PJ, Chiou C-F, Henning JM, Wade SW, et al. Examining the value and quality of health economic analyses: implications of utilizing the QHES. J Manag Care Pharm. 2003;9(1):53–61.

    PubMed  Google Scholar 

  16. Drummond MF, Stoddart GL, Torrance GW. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press; 1987.

    Google Scholar 

  17. Desai PR, Chandwani HS, Rascati KL. Assessing the quality of pharmacoeconomic studies in India. Pharmacoeconomics. 2012;30(9):749–62.

    Article  PubMed  Google Scholar 

  18. Gavaza P, Rascati KL, Oladapo AO, Khoza S. The state of health economic evaluation research in Nigeria. Pharmacoeconomics. 2010;28(7):539–53.

    Article  PubMed  Google Scholar 

  19. Gavaza P, Shepherd M, Shcherbakova N, Khoza S. The state of health economics and pharmaceoconomics research in Russia: a systematic review. J Pharm Health Serv Res. 2010;1(3):113–21.

    Article  Google Scholar 

  20. Jiang S, Ma X, Desai P, Yang L, Rascati K. A systematic review on the extent and quality of pharmacoeconomic publications for China. Value Health Reg Issues. 2014;3:79–86.

    Article  PubMed  Google Scholar 

  21. Chiou C-F, Hay JW, Wallace JF, Bloom BS, Neumann PJ, Sullivan SD, et al. Development and validation of a grading system for the quality of cost-effectiveness studies. Med Care. 2003;41(1):32–44.

    Article  PubMed  Google Scholar 

  22. Kim DD, Hutton DW, Raouf AA, Salama M, Hablas A, Seifeldin IA, et al. Cost-effectiveness model for hepatitis C screening and treatment: implications for Egypt and other countries with high prevalence. Global public health. 2015;10(3):296–317.

    Article  PubMed  Google Scholar 

  23. Obach D, Deuffic-Burban S, Esmat G, Anwar WA, Dewedar S, Canva V et al. Effectiveness and cost-effectiveness of immediate vs. delayed treatment of HCV-infected patients in a country with limited resources: the case of Egypt. Clin Infect Dis. 2014:ciu066.

  24. Elsisi GH, Aburawash A, Waked E. Cost-effectiveness analysis of new hepatitis C virus treatments in egyptian cirrhotic and noncirrhotic patients: a societal perspective. Value Health Reg Issues. 2017;13:7–15.

    Article  PubMed  Google Scholar 

  25. Sibak M, Moussa I, El-Tantawy N, Badr S, Chaudhri I, Allam E, et al. Cost-effectiveness analysis of the introduction of the pneumococcal conjugate vaccine (PCV-13) in the Egyptian national immunization program, 2013. Vaccine. 2015;33:A182–91.

    Article  PubMed  Google Scholar 

  26. Ortega O, El-Sayed N, Sanders JW, Abd-Rabou Z, Antil L, Bresee J, et al. Cost-benefit analysis of a rotavirus immunization program in the Arab Republic of Egypt. J Infect Dis. 2009;200(Supplement 1):S92–8.

    Article  PubMed  Google Scholar 

  27. Connolly MP, Topachevskyi O, Standaert B, Ortega O, Postma M. The impact of rotavirus vaccination on discounted net tax revenue in Egypt. Pharmacoeconomics. 2012;30(8):681–95.

    Article  PubMed  Google Scholar 

  28. El-Hamamsy MH, Elsisi GH, Eldessouki R, Elmazar MM, Taha AS, Awad BF et al. Economic evaluation of the combined use of warfarin and low-dose aspirin versus warfarin alone in mechanical valve prostheses. Appl Health Econ Health Policy. 2016:1–10.

  29. Atiyeh BS, Dham R, Kadry M, Abdallah AF, Al-Oteify M, Fathi O, et al. Benefit–cost analysis of moist exposed burn ointment. Burns. 2002;28(7):659–63.

    Article  PubMed  Google Scholar 

  30. Al-Aqeel SA. State of health economic evaluation research in Saudi Arabia: a review. Clinicoecon Outcomes Res CEOR. 2012;4:177.

    Article  Google Scholar 

  31. Hoque ME, Khan JA, Hossain SS, Gazi R, Rashid HA, Koehlmoos TP, et al. A systematic review of economic evaluations of health and health-related interventions in Bangladesh. Cost Eff Resour Alloc. 2011;9(1):1.

    Article  Google Scholar 

  32. Haghparast-Bidgoli H, Kiadaliri AA, Skordis-Worrall J. Do economic evaluation studies inform effective healthcare resource allocation in Iran? A critical review of the literature. Cost Eff Resour Alloc. 2014;12(1):1.

    Article  Google Scholar 

  33. Gavaza P, Rascati KL, Oladapo AO, Khoza S. The state of health economic research in South Africa. Pharmacoeconomics. 2012;30(10):925–40.

    Article  PubMed  Google Scholar 

  34. Lee K-S, Brouwer WB, Lee S-I, Koo H-W. Introducing economic evaluation as a policy tool in Korea: will decision makers get quality information? Pharmacoeconomics. 2005;23(7):709–21.

    Article  PubMed  Google Scholar 

  35. Teerawattananon Y, Russell S, Mugford M. A systematic review of economic evaluation literature in Thailand. Pharmacoeconomics. 2007;25(6):467–79.

    Article  PubMed  Google Scholar 

  36. Soliman AM, Hussein M, Abdulhalim AM. Pharmacoeconomic education in Egyptian schools of pharmacy. Am J Pharm Educ. 2013;77(3):57.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Griffiths UK, Legood R, Pitt C. Comparison of Economic Evaluation Methods Across Low-income, Middle-income and High-income Countries: What are the Differences and Why? Health Econ. 2016;25(Suppl Suppl 1):29–41. https://doi.org/10.1002/hec.3312.

  38. Gheith OA, Nematalla AH, Bakr MA, Refaie A, Shokeir AA, Ghoneim MA. Cost–benefit of steroid avoidance in renal transplant patients: a prospective randomized study. Scand J Urol Nephrol. 2010;44(3):175–82.

    Article  CAS  PubMed  Google Scholar 

  39. Harwan WA, Abbassi MM, El-Attar MM, Farid SF. Pharmacoeconomic study of antibiotics used in the treatment of lower respiratory tract infections in ICU patients: a case study in an Egyptian hospital. B-FOPCU. 2014;52(1):135–44.

    Google Scholar 

  40. El Sabaawy D, El-Haggar S, El-Bahrawy H, Waked I, El-Said H. A comparative study of variants of pegylated interferon alpha in treatment of chronic HCV patients. APMIS. 2015;123(6):482–9.

    Article  CAS  PubMed  Google Scholar 

  41. Eltabbakh M, Zaghla H, Abdel-Razek W, Elshinnawy H, Ezzat S, Gomaa A, et al. Utility and cost-effectiveness of screening for hepatocellular carcinoma in a resource-limited setting. Med Oncol. 2015;32(1):1–7.

    Article  Google Scholar 

  42. Kamal S, Kassim S, El Gohary E, Fouad A, Nabegh L, Hafez T, et al. The accuracy and cost-effectiveness of hepatitis C core antigen assay in the monitoring of anti-viral therapy in patients with chronic hepatitis C genotype 4. Aliment Pharmacol Ther. 2015;42(3):307–18.

    Article  CAS  PubMed  Google Scholar 

  43. Abdel-Raheem TA, Méabed EM, Nasef GA, Abdel Wahed WY, Rohaim RM. Efficacy, acceptability and cost effectiveness of four therapeutic agents for treatment of scabies. J Dermatol Treat. 2016:1-7.

  44. El-Khamery AA, Mohamed AI, Swify HE. Cost-effectiveness of glaucoma management with monotherapy medications in Egypt. J Adv Pharm Technol Res. 2017;8(1):25–8. https://doi.org/10.4103/2231-4040.197384.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the help of E. Said, S. Al Shabasy, A. Abdel Magid, A. Ali, MSc, and Z. Elsisi, BSc, teaching assistants in the Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Egypt, in the study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Darin Baines.

Ethics declarations

Funding

No source of funding was used for this review.

Conflict of interest

The authors declare that they have no conflicts of interest.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 140 kb)

Appendix

Appendix

1.1 List of Keywords Used in the Literature Review

The following keywords used alone and in different combinations were employed in the literature review:

  • Pharmacoeconomics

  • Economic evaluation

  • Health Economics

  • Cost

  • Effectiveness

  • Cost effectiveness

  • Cost-minimization

  • Cost-utility

  • Cost–benefit

  • Egypt

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Farid, S., Elmahdawy, M. & Baines, D. A Systematic Review on the Extent and Quality of Pharmacoeconomic Publications in Egypt. Clin Drug Investig 39, 157–168 (2019). https://doi.org/10.1007/s40261-018-0730-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40261-018-0730-5

Navigation