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Evaluating the Longitudinal Course of Atopic Dermatitis: Implications for Clinical Practice

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Abstract

Atopic dermatitis (AD) is characterized by a heterogenous longitudinal course with varying severity, flares, and persistence. However, AD course is not routinely assessed in clinical practice or controlled trials. Our objective was to review the longitudinal course of AD in children and adults and discuss implications for routine practice and clinical trials. We conducted a focused review of the published literature, including retrospective, prospective, and interventional studies, clinical trials, and consensus guidelines. Estimates of AD persistence varied widely across studies but suggested that AD can indeed persist through childhood and into adulthood. Predictors of persistence are broad and include both disease-intrinsic and disease-extrinsic (i.e., environmental) factors. In real-world practice, most individuals with AD experience fluctuations in the signs and symptoms over time and do not experience persistent clearance of skin lesions. Clinical trials use mainly static measurements that do not take into account fluctuations in course, which may confound treatment effects. The heterogenous temporal pattern of AD can be incorporated into routine practice to better set expectations and offer a realistic prognosis. AD course should be routinely incorporated into clinical decision making. Future studies are needed to develop a standardized approach to AD assessment and treatment that includes longitudinal course.

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References

  1. Silverberg JI, et al. Distribution of atopic dermatitis lesions in United States adults. J Eur Acad Dermatol Venereol. 2019;33(7):1341–8.

    CAS  PubMed  Google Scholar 

  2. Vakharia PP, et al. Burden of skin pain in atopic dermatitis. Ann Allergy Asthma Immunol. 2017;119(6):548-552.e3.

    PubMed  PubMed Central  Google Scholar 

  3. Li JC, et al. Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: a cross-sectional study. Dermatitis. 2018;29(5):270–7.

    PubMed  PubMed Central  Google Scholar 

  4. Yu SH, Silverberg JI. Association between atopic dermatitis and depression in US adults. J Investig Dermatol. 2015;135(12):3183–6.

    CAS  PubMed  Google Scholar 

  5. Silverberg JI, et al. Symptoms and diagnosis of anxiety and depression in atopic dermatitis in U.S. adults. Br J Dermatol. 2019;119(548–52):e3.

    Google Scholar 

  6. Silverberg JI. Association between adult atopic dermatitis, cardiovascular disease, and increased heart attacks in three population-based studies. Allergy. 2015;70(10):1300–8.

    CAS  PubMed  Google Scholar 

  7. Strom MA, Silverberg JI. Association between atopic dermatitis and extracutaneous infections in US adults. Br J Dermatol. 2017;176(2):495–7.

    CAS  PubMed  Google Scholar 

  8. Silverberg JI, Silverberg NB, Lee-Wong M. Association between atopic dermatitis and obesity in adulthood. Br J Dermatol. 2012;166(3):498–504.

    CAS  PubMed  Google Scholar 

  9. Silverberg JI, Simpson EL. Association between obesity and eczema prevalence, severity and poorer health in US adolescents. Dermatitis. 2014;25(4):172–81.

    PubMed  Google Scholar 

  10. Silverberg JI, Simpson EL. Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization. Pediatr Allergy Immunol. 2013;24(5):476–86.

    PubMed  PubMed Central  Google Scholar 

  11. Silverberg JI, et al. Association of atopic dermatitis with allergic, autoimmune, and cardiovascular comorbidities in US adults. Ann Allergy Asthma Immunol. 2018;121(5):604-612.e3.

    PubMed  Google Scholar 

  12. Silverberg JI. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123(2):144–51.

    PubMed  Google Scholar 

  13. Shaheen MS, Silverberg JI. Atopic dermatitis is associated with osteoporosis and osteopenia in older adults. J Am Acad Dermatol. 2019;80(2):550–1.

    PubMed  Google Scholar 

  14. Silverberg JI, et al. Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study. Ann Allergy Asthma Immunol. 2018;121(3):340–7.

    PubMed  Google Scholar 

  15. Silverberg JI, et al. Health utility scores of atopic dermatitis in US adults. J Allergy Clin Immunol Pract. 2019;7(4):1246-1252.e1.

    PubMed  Google Scholar 

  16. Drucker AM, et al. Health care resource utilization and costs among adults with atopic dermatitis in the United States: a claims-based analysis. J Allergy Clin Immunol Pract. 2018;6(4):1342–8.

    PubMed  Google Scholar 

  17. Silverberg JI. Health care utilization, patient costs, and access to care in US adults with eczema: a population-based study. JAMA Dermatol. 2015;151(7):743–52.

    PubMed  Google Scholar 

  18. Fuxench ZCC, et al. Atopic dermatitis in america study: a cross-sectional study examining the prevalence and disease burden of atopic dermatitis in the US adult population. J Investig Dermatol. 2019;139(3):583–90.

    Google Scholar 

  19. Stalder JF, et al. Severity scoring of atopic-dermatitis—the Scorad Index—consensus report of the European Task-Force on atopic-dermatitis. Dermatology. 1993;186(1):23.

    Google Scholar 

  20. Wollenberg A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32(5):657–82.

    CAS  PubMed  Google Scholar 

  21. Basra MKA, et al. The Dermatology Life Quality Index 1994–2007: a comprehensive review of validation data and clinical results. Br J Dermatol. 2008;159(5):997–1035.

    CAS  PubMed  Google Scholar 

  22. Barbier N, et al. Validation of the Eczema Area and Severity Index for atopic dermatitis in a cohort of 1550 patients from the pimecrolimus cream 1% randomized controlled clinical trials programme. Br J Dermatol. 2004;150(1):96–102.

    CAS  PubMed  Google Scholar 

  23. Chopra R, et al. Severity strata for Eczema Area and Severity Index (EASI), modified EASI, Scoring Atopic Dermatitis (SCORAD), objective SCORAD, Atopic Dermatitis Severity Index and body surface area in adolescents and adults with atopic dermatitis. Br J Dermatol. 2017;177(5):1316–21.

    CAS  PubMed  Google Scholar 

  24. Silverberg JI, et al. Severity strata for POEM, PO-SCORAD, and DLQI in US adults with atopic dermatitis. Ann Allergy Asthma Immunol. 2018;121(4):464.

    PubMed  Google Scholar 

  25. Silverberg JI, et al. Comparison of patient-oriented eczema measure and patient-oriented scoring atopic dermatitis vs Eczema Area and Severity Index and other measures of atopic dermatitis A validation study. Ann Allergy Asthma Immunol. 2020;125(1):78–83.

    PubMed  Google Scholar 

  26. Silverberg JI, et al. Validation of five patient-reported outcomes for atopic dermatitis severity in adults. Br J Dermatol. 2020;182(1):104–11.

    CAS  PubMed  Google Scholar 

  27. Margolis JS, et al. Persistence of mild to moderate atopic dermatitis. JAMA Dermatol. 2014;150(6):593–600.

    PubMed  PubMed Central  Google Scholar 

  28. Langan SM, Silcocks P, Williams HC. What causes flares of eczema in children? Br J Dermatol. 2009;161(3):640–6.

    CAS  PubMed  Google Scholar 

  29. Shaw TE, et al. Eczema prevalence in the United States: data from the 2003 National Survey of Children’s Health. J Investig Dermatol. 2011;131(1):67–73.

    CAS  PubMed  Google Scholar 

  30. Zutavern A, et al. Atopic dermatitis, extrinsic atopic dermatitis and the hygiene hypothesis: results from a cross-sectional study. Clin Exp Allergy. 2005;35(10):1301–8.

    CAS  PubMed  Google Scholar 

  31. Wüthrich B. Clinical aspects, epidemiology, and prognosis of atopic dermatitis. Ann Allergy Asthma Immunol. 1999;83(5):464–70.

    PubMed  Google Scholar 

  32. Illi S, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004;113(5):925–31.

    PubMed  Google Scholar 

  33. Ricci G, Dondi A, Neri I et al. Atopic dermatitis phenotypes in childhood. Ital J Pediatr 2014;40:46. https://doi.org/10.1186/1824-7288-40-46.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Wananukul S, et al. The natural course of childhood atopic dermatitis: a retrospective cohort study. Asian Pac J Allergy Immunol. 2015;33(2):161–8.

    PubMed  Google Scholar 

  35. Irvine AD, Mina-Osorio P. Disease trajectories in childhood atopic dermatitis: an update and practitioner’s guide. Br J Dermatol. 2019;181(5):895–906.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Silverberg JI, Simpson EL. Conclusions about atopic dermatitis persistence might be premature Reply. J Am Acad Dermatol. 2017;76(5):E179–E179.

    PubMed  Google Scholar 

  37. Abuabara K, Langan SM, Yu AM. Conclusions about atopic dermatitis persistence might be premature. J Am Acad Dermatol. 2017;76(5):E177–8.

    PubMed  Google Scholar 

  38. Kim JP, et al. Persistence of atopic dermatitis (AD): a systematic review and meta-analysis. J Am Acad Dermatol. 2016;75(4):681-687.e11.

    PubMed  PubMed Central  Google Scholar 

  39. von Kobyletzki LB, et al. Factors associated with remission of eczema in children: a population-based follow-up study. Acta Derm Venereol. 2014;94(2):179–84.

    Google Scholar 

  40. Ricci G, et al. Does improvement management of atopic dermatitis influence the appearance of respiratory allergic diseases? A follow-up study. Clin Mol Allergy. 2010;8:8.

    PubMed  PubMed Central  Google Scholar 

  41. Abuabara K, et al. Patterns and predictors of atopic dermatitis disease control past childhood: an observational cohort study. J Allergy Clin Immunol. 2018;141(2):778–80.

    PubMed  Google Scholar 

  42. Wan J, et al. Longitudinal atopic dermatitis control and persistence vary with timing of disease onset in children: a cohort study. J Am Acad Dermatol. 2019;81(6):1292–9.

    PubMed  PubMed Central  Google Scholar 

  43. McKenzie C, Silverberg JI. The prevalence and persistence of atopic dermatitis in urban United States children. Ann Allergy Asthma Immunol. 2019;123(2):173-178.e1.

    PubMed  Google Scholar 

  44. Ferrante G, Grutta SL. The burden of pediatric asthma. Front Pediatr. 2018;6:186.

    PubMed  PubMed Central  Google Scholar 

  45. Mortz CG, et al. Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities. Allergy. 2015;70(7):836–45.

    CAS  PubMed  Google Scholar 

  46. Thorsteinsdottir S, et al. Genetic, clinical, and environmental factors associated with persistent atopic dermatitis in childhood. JAMA Dermatol. 2019;155(1):50–7.

    PubMed  Google Scholar 

  47. Roduit C, et al. Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood. JAMA Pediatr. 2017;171(7):655–62.

    PubMed  PubMed Central  Google Scholar 

  48. Paternoster L, et al. Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts. J Allergy Clin Immunol. 2018;141(3):964–71.

    PubMed  PubMed Central  Google Scholar 

  49. Silverberg JI, Simpson EL. Associations of childhood eczema severity: a US population-based study. Dermatitis. 2014;25(3):107–14.

    PubMed  PubMed Central  Google Scholar 

  50. Kim Y, et al. Racial/ethnic differences in incidence and persistence of childhood atopic dermatitis. J Investig Dermatol. 2019;139(4):827–34.

    CAS  PubMed  Google Scholar 

  51. Berna R, et al. Identifying phenotypes of atopic dermatitis in a longitudinal united states cohort using unbiased statistical clustering. J Investig Dermatol. 2020;140(2):477–9.

    CAS  PubMed  Google Scholar 

  52. Silverberg JI, Hanifin J, Simpson EL. Climatic factors are associated with childhood eczema prevalence in the United States. J Investig Dermatol. 2013;133(7):1752–9.

    CAS  PubMed  Google Scholar 

  53. Silverberg JI, Paller AS. Association between eczema and stature in 9 US population-based studies. JAMA Dermatol. 2015;151(4):401–9.

    PubMed  Google Scholar 

  54. Janumpally SR, et al. In the United States, blacks and Asian/Pacific Islanders are more likely than whites to seek medical care for atopic dermatitis. Arch Dermatol. 2002;138(5):634–7.

    PubMed  Google Scholar 

  55. Fischer AH, et al. Racial and ethnic differences in health care utilization for childhood eczema: an analysis of the 2001–2013 Medical Expenditure Panel Surveys. J Am Acad Dermatol. 2017;77(6):1060–7.

    PubMed  PubMed Central  Google Scholar 

  56. Havstad S, et al. Atopic phenotypes identified with latent class analyses at age 2 years. J Allergy Clin Immunol. 2014;134(3):722.

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Brunner PM, Guttman-Yassky E. Racial differences in atopic dermatitis. Ann Allergy Asthma Immunol. 2019;122(5):449–55.

    PubMed  Google Scholar 

  58. Wan J, et al. Racial and ethnic differences in atopic dermatitis-related school absences among US children. JAMA Dermatol. 2019;155(8):973–5.

    PubMed  PubMed Central  Google Scholar 

  59. Margolis DJ, et al. Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects. J Allergy Clin Immunol. 2014;133(3):784–9.

    CAS  PubMed  Google Scholar 

  60. Wegienka G, et al. Racial disparities in allergic outcomes in African Americans emerge as early as age 2 years. Clin Exp Allergy. 2012;42(6):909–17.

    CAS  PubMed  PubMed Central  Google Scholar 

  61. Wegienka G, et al. Sensitization and allergic histories differ between black and white pregnant women. J Allergy Clin Immunol. 2012;130(3):657.

    CAS  PubMed  PubMed Central  Google Scholar 

  62. Barbarot S, et al. Strategies used for measuring long-term control in atopic dermatitis trials: a systematic review. J Am Acad Dermatol. 2016;75(5):1038–44.

    PubMed  Google Scholar 

  63. Prezzano JC, Beck LA. Long-term treatment of atopic dermatitis. Dermatol Clin. 2017;35(3):335–49.

    CAS  PubMed  Google Scholar 

  64. Schmitt J, et al. The harmonizing outcome measures for eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology. J Investig Dermatol. 2015;135(1):24–30.

    CAS  PubMed  Google Scholar 

  65. Abuabara K, et al. The prevalence of atopic dermatitis beyond childhood: a systematic review and meta-analysis of longitudinal studies. Allergy. 2018;73(3):696–704.

    CAS  PubMed  Google Scholar 

  66. Roth HL, Kierland RR. The natural history of atopic dermatitis. A 20-year follow-up study. Arch Dermatol. 1964;89:209–14.

    CAS  PubMed  Google Scholar 

  67. Rystedt I. Long term follow-up in atopic dermatitis. Acta dermato-venereologica. 1985;114:117–20. https://doi.org/10.2340/00015555114117120.

    Article  CAS  PubMed  Google Scholar 

  68. Rystedt I. Prognostic factors in atopic-dermatitis. Acta Derm Venereol. 1985;65(3):206–13.

    CAS  PubMed  Google Scholar 

  69. Lammintausta K, et al. Prognosis of atopic dermatitis. A prospective study in early adulthood. Int J Dermatol. 1991;30(8):563–8.

    CAS  PubMed  Google Scholar 

  70. Sandstrom MH, Faergemann J. Prognosis and prognostic factors in adult patients with atopic dermatitis: a long-term follow-up questionnaire study. Br J Dermatol. 2004;150(1):103–10.

    CAS  PubMed  Google Scholar 

  71. Garmhausen D, et al. Characterization of different courses of atopic dermatitis in adolescent and adult patients. Allergy. 2013;68(4):498–506.

    CAS  PubMed  Google Scholar 

  72. Hong MR, et al. A real-world study of the longitudinal course of adult atopic dermatitis severity in clinical practice. Ann Allergy Asthma Immunol. 2020;125(6):686-692.e3.

    PubMed  Google Scholar 

  73. Silverberg JI, et al. Atopic dermatitis in US adults: from population to health care utilization. J Allergy Clin Immunol Pract. 2019;7(5):1524–32.

    PubMed  Google Scholar 

  74. Silverberg JI. Racial and ethnic disparities in atopic dermatitis. Curr Dermatol Rep. 2015;4(1):44–8.

    Google Scholar 

  75. Kantor R, et al. Research letter: impact of pruritus on quality of life—a systematic review. J Am Acad Dermatol. 2016;75(5):885-886.e4.

    PubMed  PubMed Central  Google Scholar 

  76. Wittkowski A, et al. Illness perception in individuals with atopic dermatitis. Psychol Health Med. 2007;12(4):433–44.

    PubMed  Google Scholar 

  77. Simpson EL, et al. Patient burden of moderate to severe atopic dermatitis (AD): insights from a phase 2b clinical trial of dupilumab in adults. J Am Acad Dermatol. 2016;74(3):491–8.

    CAS  PubMed  Google Scholar 

  78. Yosipovitch G, Papoiu ADP. What causes itch in atopic dermatitis? Curr Allergy Asthma Rep. 2008;8(4):306–11.

    CAS  PubMed  Google Scholar 

  79. Grillo M, Long R, Long D. Habit reversal training for the itch-scratch cycle associated with pruritic skin conditions. Dermatol Nurs Dermatol Nurses’ Assoc. 2007;19(3):243–8.

    Google Scholar 

  80. Hong MR, Lei D, Yousaf M, Chavda R, Gabriel S, Janmohamed SR, Silverberg JI. Reliability and longitudinal course of itch/scratch severity in adults with atopic dermatitis. Dermatitis. 2021;32(1S):S28–S32. https://doi.org/10.1097/DER.0000000000000716.

    Article  CAS  PubMed  Google Scholar 

  81. Silverberg JI, et al. Association of itch triggers with atopic dermatitis severity and course in adults. Ann Allergy Asthma Immunol. 2020;125(5):552.

    PubMed  Google Scholar 

  82. Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Chiesa Fuxench ZC, Simpson EL, Ong PY. Pain is a common and burdensome symptom of atopic dermatitis in United States adults. J Allergy Clin Immunol Pract. 2019;7(8):2699–706.e7.

  83. Hong MR, Lei D, Yousaf M, Chavda R, Gabriel S, Silverberg JI. A real-world study of the longitudinal course of skin pain in adult atopic dermatitis. J Am Acad Dermatol. 2022;86(5):1123–27. https://doi.org/10.1016/j.jaad.2021.04.021.

    Article  PubMed  Google Scholar 

  84. Chovatiya R, Lei D, Ahmed A, Chavda R, Gabriel S, Silverberg JI. Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: a prospective observational study. Ann Allergy Asthma Immunol. 2021;127(1):83–90.e2. https://doi.org/10.1016/j.anai.2021.03.019.

  85. Boguniewicz M, et al. Atopic dermatitis yardstick: practical recommendations for an evolving therapeutic landscape. Ann Allergy Asthma Immunol. 2018;120(1):10-22.e2.

    PubMed  Google Scholar 

  86. Silverberg JI. Is the burden of atopic dermatitis iatrogenic? Presented at: revolutionizing atopic dermatitis 2020 virtual meeting. December 13–14, 2020.

  87. Cloutier MM, et al. 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020;146(6):1217–70.

    PubMed  Google Scholar 

  88. Thomas KS, et al. Validation of treatment escalation as a definition of atopic eczema flares. Plos One. 2015;10(4).

  89. Howells L, et al. Defining and measuring “eczema control”: an international qualitative study to explore the views of those living with and treating atopic eczema. J Eur Acad Dermatol Venereol. 2019;33(6):1124–32.

    CAS  PubMed  PubMed Central  Google Scholar 

  90. Chalmers JR, et al. Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). Br J Dermatol. 2018;178(5):E332–41.

    CAS  PubMed  Google Scholar 

  91. Osborne ED, Murray PF. Atopic dermatitis—a study of its natural course and of wool as a dominant allergenic factor. AMA Arch Derm Syphilol. 1953;68(6):619–26.

    CAS  PubMed  Google Scholar 

  92. Purdy MJ. The long-term prognosis in infantile eczema. BMJ. 1953;1(4824):1366–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Finn OA. Long-term prognosis in infantile eczema. BMJ. 1955;1(Mar26):772–772.

    CAS  PubMed  PubMed Central  Google Scholar 

  94. Vowles M, Warin RP, Apley J. Infantile eczema—observations on natural history and prognosis. Br J Dermatol. 1955;67(2):53–9.

    CAS  PubMed  Google Scholar 

  95. Meenan FO. Prognosis in infantile eczema. Ir J Med Sci. 1959;398:79–83.

    Google Scholar 

  96. Burrows D, Penman RW. Prognosis of the eczema-asthma syndrome. Br Med J. 1960;2(5202):825–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  97. Stifler WC, et al. A 21 year follow-up of infantile eczema. J Pediatr. 1965;66(1p2):166.

    Google Scholar 

  98. Musgrove K, Morgan JK. Infantile eczema—long-term follow-up-study. Br J Dermatol. 1976;95(4):365–72.

    CAS  PubMed  Google Scholar 

  99. Vickers CFH. The natural-history of atopic eczema. Acta Dermato-Venereologica. 1980;113–5.

  100. Vanhecke E, Leys G. Evolution of atopic-dermatitis. Dermatologica. 1981;163(5):370–5.

    CAS  Google Scholar 

  101. Queille-Roussel C, Raynaud F, Saurat JH. A prospective computerized study of 500 cases of atopic dermatitis in childhood. I. Initial analysis of 250 parameters. Acta Derm Venereol Suppl (Stockh). 1985;114:87–92.

    CAS  Google Scholar 

  102. Schudel P, Wuthrich B. Clinical course of childhood atopic neurodermatitis. A catamnestic study of 121 cases. Z Hautkr. 1985;60(6):479–86.

    CAS  PubMed  Google Scholar 

  103. Podmore P, et al. Seborrhoeic eczema–a disease entity or a clinical variant of atopic eczema? Br J Dermatol. 1986;115(3):341–50.

    CAS  PubMed  Google Scholar 

  104. Businco L, et al. Natural history of atopic dermatitis in childhood: an updated review and personal experience of a five-year follow-up. Allergy. 1989;44(Suppl 9):70–8.

    PubMed  Google Scholar 

  105. Linna O, et al. Ten-year prognosis for generalized infantile eczema. Acta Paediatr. 1992;81(12):1013–6.

    CAS  PubMed  Google Scholar 

  106. Kissling S, Wuthrich B. Follow-up of atopic dermatitis after early childhood. Hautarzt. 1993;44(9):569–73.

    CAS  PubMed  Google Scholar 

  107. Belgrave DC, Granell R, Simpson A, Guiver J, Bishop C, Buchan I, Henderson AJ, Custovic A. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med. 2014;11(10):e1001748. https://doi.org/10.1371/journal.pmed.1001748.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

This manuscript was created based on a lecture presented at the 2020 annual Revolutionizing Atopic Dermatitis (RAD) international, multidisciplinary conferences on June 13, 2020 and December 12, 2020.

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Authors and Affiliations

  1. Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA

    Raj Chovatiya

  2. Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Suite 2B-425, 2150 Pennsylvania Avenue, Washington, DC, 20037, USA

    Jonathan I. Silverberg

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Correspondence to Jonathan I. Silverberg.

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Raj Chovatiya has served as an advisory board member, consultant, and/or investigator for AbbVie, Arcutis, Arena, Dermavant, Incyte, National Eczema Association, Pfizer, Regeneron, and Sanofi-Genzyme and as a speaker for AbbVie, Incyte, Regeneron, Sanofi-Genzyme, and UCB. Jonathan Silverberg has received personal fees from AbbVie, Afyx, Arena, Asana, BioMX, Bluefin, Bodewell, Boehringer Ingelheim, Celgene, Dermavant, Dermira, Eli Lilly, Galderma, GlaxoSmithKline, Incyte, Kiniksa, Leo, Luna, Menlo, Novartis, Pfizer, RAPT, Regeneron, and Sanofi-Genzyme; their institution has received grants from Galderma.

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Study concept and design: JIS. Acquisition, analysis, and interpretation of data; statistical analysis; and drafting and critical revision of the manuscript for important intellectual content: RC, JIS.

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Chovatiya, R., Silverberg, J.I. Evaluating the Longitudinal Course of Atopic Dermatitis: Implications for Clinical Practice. Am J Clin Dermatol 23, 459–468 (2022). https://doi.org/10.1007/s40257-022-00697-w

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